scholarly journals i080 Recruitment, follow-up and ensuring good quality data in clinical research

Rheumatology ◽  
2018 ◽  
Vol 57 (suppl_3) ◽  
Author(s):  
Zoe Plummer
Keyword(s):  
Clinical Research ◽  
Quality Data ◽  
Good Quality Data

scholarly journals The Fermented Soy Beverage Q-CAN® Plus Induces Beneficial Changes in the Oral and Intestinal Microbiome

2020 ◽  
Author(s):  
Evangelos Dioletis ◽  
Ricardo Paiva ◽  
Eleanna Kaffe ◽  
Eric R. Secor ◽  
Theresa R. Weiss ◽  
...  
Keyword(s):  
Oral Microbiome ◽  
Intestinal Microbiome ◽  
Quality Data ◽  
Positive Health ◽  
Fecal Microbiome ◽  
The Family ◽  
Stool Samples ◽  
Microbial Dna ◽  
Good Quality Data

Abstract Background: Soy products are associated with many beneficial health consequences, but their effects on the human intestinal microbiome are poorly characterized. Objectives: To identify the changes in the oral and fecal microbiome in lean and obese participants due to consumption of Q-CAN®, and to assess the expected consequences of these changes based on the published literature. Methods: Prospective study of lean (10) and obese (9) participants consuming Q-CAN® twice daily for 4 weeks with 8 weeks follow-up. Microbial DNA was extracted from saliva and stool samples, amplified against the V4 region of the 16S ribosomal RNA gene and data analyzed using QIIME 1.9.1 bioinformatics. 440 samples were collected in total, 424 of which were productive and yielded good quality data. Results: STOOL. In the lean population Bifidobacteria and Blautia show a significant increase while taking Q-CAN®, and there was a trend for this in the obese population. ORAL. There were relatively fewer major changes in the oral microbiome with an increase in the family Veillonellaceae in the lean population while on Q-CAN®. Conclusion: Q-CAN® consumption induced a number of significant changes in the fecal and oral microbiome. Most notably an increase in the stool microbiome of Bifidobacteria and Blautia, both of which are associated with positive health benefits, and in the saliva an increase in Veillonellaceae. Trial registration: This trial was registered with Clinicaltrials.gov on January 14th 2016. ClinicalTrials.gov Identifier: NCT02656056

scholarly journals The fermented soy beverage Q-CAN® plus induces beneficial changes in the oral and intestinal microbiome

BMC Nutrition ◽  
2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Evangelos Dioletis ◽  
Ricardo S. Paiva ◽  
Eleanna Kaffe ◽  
Eric R. Secor ◽  
Theresa R. Weiss ◽  
...  
Keyword(s):  
Oral Microbiome ◽  
Intestinal Microbiome ◽  
Quality Data ◽  
Positive Health ◽  
Fecal Microbiome ◽  
The Family ◽  
Stool Samples ◽  
Microbial Dna ◽  
Good Quality Data

Abstract Background Soy products are associated with many beneficial health consequences, but their effects on the human intestinal microbiome are poorly characterized. Objectives To identify the changes in the oral and fecal microbiome in lean and obese participants due to consumption of Q-CAN®, and to assess the expected consequences of these changes based on the published literature. Methods Prospective study of lean (10) and obese (9) participants consuming Q-CAN® twice daily for 4 weeks with 8 weeks follow-up. Microbial DNA was extracted from saliva and stool samples, amplified against the V4 region of the 16S ribosomal RNA gene and data analyzed using QIIME 1.9.1 bioinformatics. Four hundred forty-four samples were collected in total, 424 of which were productive and yielded good quality data. Results STOOL. In the lean population Bifidobacteria and Blautia show a significant increase while taking Q-CAN®, and there was a trend for this in the obese population. ORAL. There were relatively fewer major changes in the oral microbiome with an increase in the family Veillonellaceae in the lean population while on Q-CAN®. Conclusion Q-CAN® consumption induced a number of significant changes in the fecal and oral microbiome. Most notably an increase in the stool microbiome of Bifidobacteria and Blautia, both of which are associated with positive health benefits, and in the saliva an increase in Veillonellaceae. Trial registration This trial was registered with Clinicaltrials.gov on January 14th 2016. ClinicalTrials.gov Identifier: NCT02656056

scholarly journals Structural and functional radiomics for lung cancer

2021 ◽  
Author(s):  
Guangyao Wu ◽  
Arthur Jochems ◽  
Turkey Refaee ◽  
Abdalla Ibrahim ◽  
Chenggong Yan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Treatment Strategy ◽  
Early Stage ◽  
Quality Data ◽  
Clinical Implementation ◽  
Early Stage Lung Cancer ◽  
Treatment Response Evaluation ◽  
Advanced Stage Lung Cancer ◽  
Stage Lung Cancer

Abstract Introduction Lung cancer ranks second in new cancer cases and first in cancer-related deaths worldwide. Precision medicine is working on altering treatment approaches and improving outcomes in this patient population. Radiological images are a powerful non-invasive tool in the screening and diagnosis of early-stage lung cancer, treatment strategy support, prognosis assessment, and follow-up for advanced-stage lung cancer. Recently, radiological features have evolved from solely semantic to include (handcrafted and deep) radiomic features. Radiomics entails the extraction and analysis of quantitative features from medical images using mathematical and machine learning methods to explore possible ties with biology and clinical outcomes. Methods Here, we outline the latest applications of both structural and functional radiomics in detection, diagnosis, and prediction of pathology, gene mutation, treatment strategy, follow-up, treatment response evaluation, and prognosis in the field of lung cancer. Conclusion The major drawbacks of radiomics are the lack of large datasets with high-quality data, standardization of methodology, the black-box nature of deep learning, and reproducibility. The prerequisite for the clinical implementation of radiomics is that these limitations are addressed. Future directions include a safer and more efficient model-training mode, merge multi-modality images, and combined multi-discipline or multi-omics to form “Medomics.”

Thermodynamics of Adsorption of Alcohol Dehydrogenase on Gold Nanoparticle Surface: A Model Based Analysis Versus Direct Measurement

2021 ◽  
Author(s):  
Akriti Mishra ◽  
Kamini Mishra ◽  
Dipayan Bose ◽  
Abhijit Chakrabarti ◽  
Puspendu Kumar Das
Keyword(s):  
Alcohol Dehydrogenase ◽  
Gold Nanoparticle ◽  
Protein Interaction ◽  
Protein Corona ◽  
Quality Data ◽  
Nanoparticle Surface ◽  
Tremendous Importance ◽  
Good Quality Data ◽  
Model Based Analysis

Characterization of nanoparticle protein corona has gained tremendous importance lately. The parameters which quantitatively establish a specific nanoparticle-protein interaction need to be measured accurately since good quality data is necessary...

Aerosol Assimilation of lidar data from Satellite (AEOLUS) and Ground-based (EARLINET) instruments in COMPO-IFS.

2021 ◽  
Author(s):  
Julie Letertre-Danczak ◽  
Angela Benedetti ◽  
Drasko Vasiljevic ◽  
Alain Dabas ◽  
Thomas Flament ◽  
...  
Keyword(s):  
Quality Data ◽  
Lidar Data ◽  
Operational Model ◽  
Weather Forecasts ◽  
The Past ◽  
Medium Range ◽  
First Results ◽  
Monitoring Service ◽  
The Vertical Distribution ◽  
Good Quality Data

<p>Since several years, the number of aerosol data coming from lidar has grown and improved in quality. These new datasets are providing a valuable information on the vertical distribution of aerosols which is missing in the AOD (Aerosol Optical Depth), which has been used so far in aerosols analysis. The launch of AEOLUS in 2018 has increased the interest in the assimilation of the aerosol lidar information. In parallel, the ground-based network EARLINET (European Aerosol Research LIdar NETwork) has grown to cover the Europe with good quality data. Assimilation of these data in the ECMWF/CAMS (European Centre for Medium-range Weather Forecasts / Copernicus Atmosphere Monitoring Service) system is expected to provide improvements in the aerosol analyses and forecasts.<br><br>Three preliminary studies have been done in the past four years using AEOLUS data (A3S-ESA funded) and EARLINET data (ACTRIS-2 and EUNADIC-AV, EU-funded). These studies have allowed the full development of the tangent linear and adjoint code for lidar backscatter in the ECMWF's 4D-VAR system. These developments are now in the operational model version in research mode. The first results are promising and open the path to more intake of aerosol lidar data for assimilation purposes. The future launch of EARTHCARE (Earth-Cloud Aerosol and Radiation Explorer) and later ACCP (Aerosol Cloud, Convention and Precipitation) might even upgrade the use of aerosol lidar data in COMPO-IFS (Composition-Integrated Forecast system).<br><br>The most recent results using AEOLUS data (for October 2019 and April 2020) and using EARLINET data (October 2020) will be shown in this presentation. The output will be compared to the CAMS operational aerosol forecast as well as to independent data from AERONET (AErosol Robotic NETwork).</p>

scholarly journals Establishment of a New Platform for the Management of Patients After Cardiac Surgery: Descriptive Study (Preprint)

2018 ◽  
Author(s):  
Zhihui Zhu ◽  
Haibo Zhang ◽  
Yuehuan Li ◽  
Xu Meng ◽  
Yuqing Jiao ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Clinical Data ◽  
Academic Research ◽  
Mobile Network ◽  
Clinical Work ◽  
Quality Data ◽  
Radiographic Images ◽  
Term Survival ◽  
Echocardiographic Images

BACKGROUND Medical care for the Chinese population has been focused on first-line treatment, but with little follow-up on treated patients. As an important part of clinical work, follow-up evaluations are of great significance for the long-term survival of patients and for clinical and scientific research. However, the overall follow-up rate of discharged patients after surgery has been low for many years because of the limitations of certain follow-up methods and the presence of objective, practical problems. OBJECTIVE This study aimed to construct a new two-way interactive telemedicine follow-up platform to improve the collection of clinical data after cardiac surgery and provide reliable and high-quality follow-up services. METHODS Computer and network technologies were employed in the context of “Internet +” to develop follow-up databases and software compatible with a mobile network. Postoperative follow-up quality data including the follow-up rate and important postoperative indices were used as standards to evaluate the new follow-up management model after cardiac surgery. RESULTS This system has been officially operated for more than 5 years. A total of 5347 patients undergoing cardiac surgery have been enrolled, and the total follow-up rate was 90.22%. In addition, 6349 echocardiographic images, 4717 electrocardiographic images, and 3504 chest radiographic images have been uploaded during follow-up assessments. The international standardized ratio was 20,696 person-times. CONCLUSIONS This new management follow-up platform can be used to effectively collect clinical data, provide technical support for academic research, extend medical services, and provide more help to patients. It is of great significance for managing patients after cardiac surgery.

scholarly journals Global AgeWatch Index and Insights

2020 ◽  
Author(s):  
Gibran Cruz-Martinez ◽  
Gokce Cerev
Keyword(s):  
Older People ◽  
Composite Index ◽  
Quality Data ◽  
Transformative Change ◽  
Middle Income ◽  
Middle Income Countries ◽  
Good Quality Data ◽  
Low And Middle Income

Global AgeWatch Index and Insights by HelpAge International aim to contribute to achievement of long-term transformative change in respect to ageing and the lives of older people by advocating for better production of timely and good quality data to inform policy and program response.The Global AgeWatch Index is a composite index that measures quality of life of older people, and ranks countries based on four domains – income security, health status, enabling environment and capability. The index was developed in partnership with Professor Asghar Zaidi. The index was published during 2013-2015.The Global AgeWatch Insights is a research-based advocacy tool that examines situation of older people in low- and middle-income countries, assesses availability of relevant data and evidence to support the analysis, and identification of policy actions. The Insights are produced in partnership with AARP. The reports were launched in 2018 are planned to be released every three years with a different thematic focus. The first report focuses on the inequities of the health systems in twelve low- and middle-income countries.

Enrolment of children in clinical research: Understanding Ghanaian caregivers’ perspectives on consent/assent procedures, and their attitudes towards storage of biological samples for future use

2020 ◽  
pp. 147775092095857
Author(s):  
George O Adjei ◽  
Amos Laar ◽  
Jorgen AL Kurtzhals ◽  
Bamenla Q Goka
Keyword(s):  
Clinical Research ◽  
Biological Samples ◽  
Consent Process ◽  
Future Research ◽  
Best Interest ◽  
Context Specific ◽  
Process Context ◽  
Depth Interviews ◽  
Stored Blood

Child assent is recommended in addition to parental consent when enrolling children in clinical research; however, appreciation and relevance ascribed to these concepts vary in different contexts, and information on attitudes towards storage of biological samples for future research is limited, especially in developing countries. We assessed caregivers’ understanding and appreciation of consent and assent procedures, and their attitudes towards use of stored blood samples for future research prior to enrolling a child in clinical research. A total of 17 in-depth interviews were conducted with primary caregivers of children (fathers [n = 3], mothers [n = 12], and grandmothers [n = 2]) at enrolment or on the immediate follow-up date. All caregivers recalled significant amount information from the study information sheet and were able to appropriately link such information to the consent process. While all participants confirmed information received prior to blood sampling as adequate, a few noted that the purpose was not sufficiently well communicated. Caregivers felt children were cognitively vulnerable, and prone to decisions that were not necessarily in their best interest. Nearly all caregivers felt it was their right and responsibility to overrule objections from their ward’s regarding enrolment into specific study or receipt of a therapeutic procedure. There were no objections or concerns regarding use of stored biological samples for future research purposes. There is thus, a need to improve understanding of caregivers on the information provided during the informed consent process. Context-specific studies on the age of assent in specific populations are needed.

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