The Mayak Worker Dosimetry System (MWDS-2013): Uncertainty in the Measurement of Pu Activity in a 24-Hour Urine Sample of a Typical Mayak PA Worker

2016 ◽  
Author(s):  
Vadim Vostrotin ◽  
Alan Birchall ◽  
Alexey Zhdanov ◽  
Demetrio Gregoratto ◽  
Klara Suslova ◽  
...  
Keyword(s):  
Urine Sample ◽  
Dosimetry System

SUPRESSION OF ANDROGEN AND OESTROGEN PRODUCTION IN NORMAL MEN

1972 ◽  
Vol 70 (2) ◽  
pp. 342-350 ◽  
Author(s):  
M. A. Kirschner ◽  
D. W. R. Knorr
Keyword(s):  
Urine Sample ◽  
Plasma Testosterone ◽  
Low Level ◽  
Normal Men

ABSTRACT An attempt was made to suppress production of androgens and oestrogens in normal men by administering large doses of exogenous androgens and corticoids. After 5 days of 40 mg fluoxymesterone qd, plasma testosterone concentrations decreased from 509 to 73 ng/100 ml (85%); on adding 8 mg qd of dexamethasone, there was a further decrease to 45 ng/100 ml. Androstenedione concentrations were decreased equally by fluoxymesterone and corticoids. To monitor the suppressive effects of exogenous steroids, urinary LH was followed serially by radioimmunoassay, and decreased to only 40% of control levels after 5 days of fluoxymesterone, with no further suppression noted on adding dexamethasone. Nanogram quantities of steroidal metabolites were not adsorbed by kaolin extraction of urine, thus enabling gonadotrophins (kaolin extract) and low-level steroids (supernate) to be measured in the same urine sample. Urinary oestrone and oestradiol excretion decreased during 5 days of fluoxymesterone, and continued to fall when dexamethasone was added. In no case was oestrone or oestradiol excretion, urinary LH or plasma androgens completely suppressed by large doses of fluoxymesterone alone, or in combination with large doses of dexamethasone.

UNTERSUCHUNGEN ÜBER DIE EXTRAKTION DES ROTEN KOBER-FARBSTOFFS DURCH ORGANISCHE LÖSUNGSMITTEL ZUR ÖSTROGENBESTIMMUNG IM HARN

1960 ◽  
Vol XXXV (I) ◽  
pp. 34-48 ◽  
Author(s):  
Gerd Ittrich
Keyword(s):  
Menstrual Cycle ◽  
Organic Solvents ◽  
Urine Sample ◽  
Phenol Derivatives ◽  
Organische Lösungsmittel ◽  
Colour Complex

ABSTRACT A series of organic solvents and phenol derivatives have been examined for the extraction of the pink Kober-colour complex. Optimal results could be achieved for fluorimetry by a solution of 2 % (w/v) p-nitrophenol and 1 % (v/v) ethanol in acetylenetetrabromide, when the green mercury line (546 mμ was used as primary light. The sensitivity, stability and specificity have been improved, compared with the previously described reaction. By changing the sequence of purification steps and by reducing the volume of the urine sample (5 ml) the method for the determination of total oestrogens has been simplified. Approximately 10 determinations can be done within 3–4 hours by one person. Recovery experiments and comparative determinations with a previously described method have been carried out. The excretion of total oestrogens in a complete menstrual cycle is determined with the described method.

Radiation Exposure of Anaesthetists Visualised by Real-time Dosimetry

2019 ◽  
Vol 15 (2) ◽  
pp. 220-226
Author(s):  
Marcus Christian Müller ◽  
Michael Windemuth ◽  
Sophie Frege ◽  
Eva Nadine Striepens
Keyword(s):  
Radiation Exposure ◽  
Real Time ◽  
Vertebral Fractures ◽  
Plate Osteosynthesis ◽  
Plate Fixation ◽  
Femoral Fractures ◽  
Dose Monitoring ◽  
Osteoporotic Vertebral Fractures ◽  
Radiation Dose Monitoring ◽  
Dosimetry System

Background: Chronic exposure to occupational ionising radiation is seen as one reason for elevated cancer prevalence. </P><P> Objective: The aim of this retrospective study was to evaluate radiation exposure of anaesthetists by real-time dosimetry. Methods: Data of 296 patients were analyzed. Ten types of trauma operation procedures including osteosynthesis of upper and lower extremity fractures and minimally invasive stabilisation of traumatic and osteoporotic vertebral fractures were accomplished. Evaluation was performed by an occupational dosimetry system, which visualises anaesthetists radiation exposure feedback compared to surgeons in real-time. Results: A significantly lower radiation exposure to anaesthetists compared to surgeons was observed in four types of operative procedures: Plate fixation of proximal humerus fractures, osteosynthesis of proximal femoral fractures, stabilisation of traumatic and osteoporotic vertebral fractures. In four types of operations (plate osteosynthesis of proximal humeral, distal radial and tibial fractures and intramedullary nailing of the clavicle), anaesthetists` amount of radiation exceeded one-third of the surgeons' exposure, especially if the C-arm tube was positioned close to the anaesthetists work station at the patients' head. Conclusion: By using the occupational radiation dose monitoring system, radiation exposure to anaesthetists was visualised in real-time during trauma operations. Radiation exposure of anaesthetists depends on the type of operation and the position of the C-arm. The system may help to increase anaesthetists` awareness concerning radiation exposure and to enhance compliance in using radiation protection techniques.

scholarly journals Breast Cancer Detection from a Urine Sample by Dog Sniffing: A Preliminary Study for the Development of a New Screening Device and a Literature Review

Biology ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 517
Author(s):  
Shoko Kure ◽  
Shinya Iida ◽  
Marina Yamada ◽  
Hiroyuki Takei ◽  
Naoyuki Yamashita ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Screening ◽  
Cancer Patients ◽  
Urine Sample ◽  
Urine Samples ◽  
Breast Cancer Patients ◽  
Double Blind ◽  
Blind Test ◽  
Preliminary Study ◽  
Detect Breast Cancer

Background: Breast cancer is a leading cause of cancer death worldwide. Several studies have demonstrated that dogs can sniff and detect cancer in the breath or urine sample of a patient. This study aims to assess whether the urine sample can be used for breast cancer screening by its fingerprints of volatile organic compounds using a single trained sniffer dog. This is a preliminary study for developing the “electronic nose” for cancer screening. Methods: A nine-year-old female Labrador Retriever was trained to identify cancer from urine samples of breast cancer patients. Urine samples from patients histologically diagnosed with primary breast cancer, those with non-breast malignant diseases, and healthy volunteers were obtained, and a double-blind test was performed. Total of 40 patients with breast cancer, 142 patients with non-breast malignant diseases, and 18 healthy volunteers were enrolled, and their urine samples were collected. Results: In 40 times out of 40 runs of a double-blind test, the trained dog could correctly identify urine samples of breast cancer patients. Sensitivity and specificity of this breast cancer detection method using dog sniffing were both 100%. Conclusions: The trained dog in this study could accurately detect breast cancer from urine samples of breast cancer patients. These results indicate the feasibility of a method to detect breast cancer from urine samples using dog sniffing in the diagnosis of breast cancer. Although the methodological standardization is still an issue to be discussed, the current result warrants further study for developing a new breast cancer screening method based on volatile organic compounds in urine samples.

WS10.4 Sodium status in patients with cystic fibrosis: how to monitor based on urine sample?

2021 ◽  
Vol 20 ◽  
pp. S20
Author(s):  
S. Van Biervliet ◽  
D. Declercq ◽  
S. Vande Velde ◽  
R. De Bruyne ◽  
Y. VandeWeygaerde ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Urine Sample
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