F89. COGNITIVE IMPAIRMENT WORSENING ACROSS AFFECTIVE TO PSYCHOSIS SPECTRUM: A COHORT STUDY OF UNIPOLAR/BIPOLAR DEPRESSION AND BIPOLAR SCHIZOAFFECTIVE DISORDERS

IntroductionThe current diagnostic pathways for cognitive impairment rarely identify babies at risk before 2 years of age. Very early detection and timely targeted intervention has potential to improve outcomes for these children and support them to reach their full life potential. Early Moves aims to identify early biomarkers, including general movements (GMs), for babies at risk of cognitive impairment, allowing early intervention within critical developmental windows to enable these children to have the best possible start to life.Method and analysisEarly Moves is a double-masked prospective cohort study that will recruit 3000 term and preterm babies from a secondary care setting. Early Moves will determine the diagnostic value of abnormal GMs (at writhing and fidgety age) for mild, moderate and severe cognitive delay at 2 years measured by the Bayley-4. Parents will use the Baby Moves smartphone application to video their babies’ GMs. Trained GMs assessors will be masked to any risk factors and assessors of the primary outcome will be masked to the GMs result. Automated scoring of GMs will be developed through applying machine-based learning to the data and the predictive value for an abnormal GM will be investigated. Screening algorithms for identification of children at risk of cognitive impairment, using the GM assessment (GMA), and routinely collected social and environmental profile data will be developed to allow more accurate prediction of cognitive outcome at 2 years. A cost evaluation for GMA implementation in preparation for national implementation will be undertaken including exploring the relationship between cognitive status and healthcare utilisation, medical costs, health-related quality of life and caregiver burden.Ethics and disseminationEthics approval has been granted by the Medical Research Ethics Committee of Joondalup Health Services and the Health Service Human Research Ethics Committee (1902) of Curtin University (HRE2019-0739).Trial registration numberACTRN12619001422112.

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Fine or Gross Motor Index as a Simple Tool for Predicting Cognitive Impairment in Elderly People: Findings from The Irish Longitudinal Study on Ageing (TILDA)

Journal of Alzheimer s Disease ◽

10.3233/jad-210704 ◽

2021 ◽

pp. 1-8

Author(s):

Xiao Liu ◽

Ayiguli Abudukeremu ◽

Yuan Jiang ◽

Zhengyu Cao ◽

Maoxiong Wu ◽

...

Keyword(s):

Cohort Study ◽

Cognitive Impairment ◽

Longitudinal Study ◽

Cognitive Function ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Simple Tool

Background: Several kinds of motor dysfunction can predict future cognitive impairment in elderly individuals. However, the ability of the fine motor index (FINEA) and gross motor index (GROSSA) to predict the risk of cognitive impairment has not been assessed. Objective: We investigated the associations between FINEA/GROSSA and cognitive impairment. Methods: The data of 4,745 participants from The Irish Longitudinal Study on Ageing (TILDA) were analyzed. Cognitive function was assessed using the Mini-Mental State Examination (MMSE). We first assessed the correlation between the FINEA GROSSA and MMSE in a cross-sectional study. Then, we further investigated the predictive role of the incidence of cognitive impairment in a prospective cohort study. Results: We found that both FINEA and GROSSA were negatively correlated with MMSE in both the unadjusted (FINEA: B = –1.00, 95%confidence intervals (CI): –1.17, –0.83, t = –11.53, p < 0.001; GROSSA: B = –0.85, 95%CI: –0.94, –0.76, t = –18.29, p < 0.001) and adjusted (FINEA: B = –0.63, 95%CI: –0.79, –0.47, t = –7.77, p < 0.001; GROSSA: B = –0.57, 95%CI: –0.66, –0.48, t = –12.61, p < 0.001) analyses in a cross-sectional study. In a prospective cohort study, both high FINEA and high GROSSA were associated with an increased incidence of cognitive function impairment (FINEA: adjusted odds ratios (OR) = 2.35, 95%CI: 1.05, 5.23, p = 0.036; GROSSA adjusted OR = 3.00, 95%CI: 1.49, 6.03, p = 0.002) after 2 years of follow-up. Conclusion: Higher FINEA and GROSSA scores were both associated with an increased incidence of cognitive impairment. FINEA or GROSSA might be a simple tool for identifying patients with cognitive impairment.

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Association between dietary diversity and cognitive impairment among the oldest-old: findings from a nationwide cohort study

Clinical Nutrition ◽

10.1016/j.clnu.2021.02.041 ◽

2021 ◽

Author(s):

Jiazhen Zheng ◽

Rui Zhou ◽

Furong Li ◽

Liren Chen ◽

Keyi Wu ◽

...

Keyword(s):

Cohort Study ◽

Cognitive Impairment ◽

Dietary Diversity ◽

Oldest Old

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P1-423: THE EFFECTS OF APOE EPSILON4 ALLELES ON COGNITIVE FUNCTION AND RESTING STATE FUNCTIONAL MRI IN PATIENTS WITH AMNESTIC MILD COGNITIVE IMPAIRMENT: A PROSPECTIVE COHORT STUDY

Alzheimer s & Dementia ◽

10.1016/j.jalz.2018.06.432 ◽

2006 ◽

Vol 14 (7S_Part_8) ◽

pp. P467-P468

Author(s):

Guanqun Chen ◽

Mingrui Xia ◽

Yu Sun ◽

Yuxia Li ◽

Hong-yan Li ◽

...

Keyword(s):

Cohort Study ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Cognitive Function ◽

Functional Mri ◽

Prospective Cohort Study ◽

Resting State ◽

Prospective Cohort ◽

Amnestic Mild Cognitive Impairment

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Association between tooth loss and cognitive impairment in community-dwelling older Japanese adults: a 4-year prospective cohort study from the Ohasama study

BMC Oral Health ◽

10.1186/s12903-018-0602-7 ◽

2018 ◽

Vol 18 (1) ◽

Cited By ~ 14

Author(s):

Sho Saito ◽

Takashi Ohi ◽

Takahisa Murakami ◽

Takamasa Komiyama ◽

Yoshitada Miyoshi ◽

...

Keyword(s):

Cohort Study ◽

Cognitive Impairment ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Tooth Loss ◽

Community Dwelling ◽

Japanese Adults

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Relations of magnesium intake to cognitive impairment and dementia among participants in the Women’s Health Initiative Memory Study: a prospective cohort study

BMJ Open ◽

10.1136/bmjopen-2019-030052 ◽

2019 ◽

Vol 9 (11) ◽

pp. e030052 ◽

Cited By ~ 2

Author(s):

Kenneth Lo ◽

Qing Liu ◽

Tracy Madsen ◽

Steve Rapp ◽

Jiu-Chiuan Chen ◽

...

Keyword(s):

Cohort Study ◽

Cognitive Impairment ◽

Women's Health ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Lower Risk ◽

Women's Health Initiative ◽

Women’S Health Initiative ◽

Health Initiative ◽

The Women’S Health Initiative

ObjectiveTo examine the associations of dietary and supplemental magnesium (Mg) as assessed by a semi-quantitative food frequency questionnaire with cognitive outcomes among ageing women.DesignThis work conducts a prospective cohort study of participants enrolled in the Women’s Health Initiative Memory Study (WHIMS), which was subsequently extended and named WHIMS-Epidemiology of Cognitive Health.SettingForty clinical centres in the USA.ParticipantsPostmenopausal women aged 65–79 years without dementia on enrolment.Main outcome measuresPhysician-adjudicated mild cognitive impairment (MCI) and/or probable dementia (PD).ResultsParticipants were excluded (n=1006) if they had extreme values of dietary energy intake, had missing or extreme body mass index values, with prevalent MCI/PD at baseline, received only one cognitive assessment or had been followed up for <1 year. During >20 years of follow-up, 765 (11.8%) out of 6473 participants developed MCI/PD. For MCI/PD and MCI, the risks tended to be lower among participants in quintiles Q2–Q5 of Mg consumption compared with those in the lowest quintile. Participants in Q3 had a significantly lower risk of MCI/PD (HR 0.69, 95% CI 0.53 to 0.91) and MCI (HR 0.63, 95% CI 0.45 to 0.87) after multivariate adjustments. No significant association was observed between total Mg intake and PD. The association between total Mg intake, MCI/PD and MCI was non-linear as suggested by the likelihood test.ConclusionsTotal Mg intake between the estimated average requirement and the recommended dietary allowances may associate with a lower risk of MCI/PD and MCI.Trial registration numberNCT00685009.

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