scholarly journals Altered Circadian and Homeostatic Sleep Regulation in Prokineticin 2-Deficient Mice

SLEEP ◽  
2007 ◽  
Keyword(s):  
Sleep Regulation ◽  
Prokineticin 2 ◽  
Deficient Mice

scholarly journals Sleep and Sleep Regulation in Normal and Prion Protein-Deficient Mice

1997 ◽  
Vol 17 (5) ◽  
pp. 1869-1879 ◽  
Author(s):  
Irene Tobler ◽  
Tom Deboer ◽  
Marek Fischer
Keyword(s):  
Prion Protein ◽  
Sleep Regulation ◽  
Deficient Mice

Minireview: Sleep regulation in adenosine A2A receptor-deficient mice

Neurology ◽  
2003 ◽  
Vol 61 (Issue 11, Supplement 6) ◽  
pp. S94-S96 ◽  
Author(s):  
Y. Urade ◽  
N. Eguchi ◽  
W.-M. Qu ◽  
M. Sakata ◽  
Z.-L. Huang ◽  
...  
Keyword(s):  
Adenosine A2a Receptor ◽  
Sleep Regulation ◽  
A2a Receptor ◽  
Adenosine A2a ◽  
Deficient Mice

Cytokine- and microbially induced sleep responses of interleukin-10 deficient mice

2001 ◽  
Vol 280 (6) ◽  
pp. R1806-R1814 ◽  
Author(s):  
Linda A. Toth ◽  
Mark R. Opp
Keyword(s):  
Tumor Necrosis ◽  
Slow Wave Sleep ◽  
Interleukin 10 ◽  
Dark Phase ◽  
Sleep Regulation ◽  
Dark Cycle ◽  
Profound Hypothermia ◽  
The Impact ◽  
Deficient Mice ◽  
Necrosis Factor

Interleukin (IL)-1 and tumor necrosis factor (TNF) promote slow-wave sleep (SWS), whereas IL-10 inhibits the synthesis of IL-1 and TNF and promotes waking. We evaluated the impact of endogenous IL-10 on sleep-wake behavior by studying mice that lack a functional IL-10 gene. Under baseline conditions, C57BL/6-IL-10 knockout (KO) mice spent more time in SWS during the dark phase of the light-dark cycle than did genetically intact C57BL/6 mice. The two strains of mice showed generally comparable responses to treatment with IL-1, IL-10, or influenza virus, but differed in their responses to lipopolysaccharide (LPS). In IL-10 KO mice, LPS induced an initial transient increase and a subsequent prolonged decrease in SWS, as well as profound hypothermia. These responses were not observed in LPS-treated C57BL/6 mice. These data demonstrate that in the absence of endogenous IL-10, spontaneous SWS is increased and the impact of LPS on vigilance states is altered. Collectively, these observations support a role for IL-10 in sleep regulation and provide further evidence for the involvement of cytokines in the regulation of sleep.

Comparison of localization of metallothionein in tissues of metallothionein-deficient mice

1995 ◽  
Vol 53 ◽  
pp. 1042-1043
Author(s):  
H. Nishimura ◽  
R Nishimura ◽  
D.L. Adelson ◽  
A.E. Michaelska ◽  
K.H.A. Choo ◽  
...  
Keyword(s):  
Metal Binding ◽  
Immunohistochemical Staining ◽  
Squamous Epithelium ◽  
Rabbit Antiserum ◽  
Slight Modification ◽  
Positive Control ◽  
Heavy Metal Binding ◽  
Critical Organ ◽  
Metal Binding Protein ◽  
Deficient Mice

Metallothionein (MT), a cysteine-rich heavy metal binding protein, has several isoforms designated from I to IV. Its major isoforms, I and II, can be induced by heavy metals like cadmium (Cd) and, are present in various organs of man and animals. Rodent testes are a critical organ to Cd and it is still a controversial matter whether MT exists in the testis although it is clear that MT is not induced by Cd in this tissue. MT-IV mRNA was found to localize within tongue squamous epithelium. Whether MT-III is present mainly glial cells or neurons has become a debatable topic. In the present study, we have utilized MT-I and II gene targeted mice and compared MT localization in various tissues from both MT-deficient mice and C57Black/6J mice (C57BL) which were used as an MT-positive control. For MT immunostaining, we have used rabbit antiserum against rat MT-I known to cross-react with mammalian MT-I and II and human MT-III. Immunohistochemical staining was conducted by the method described in the previous paper with a slight modification after the tissues were fixed in HistoChoice and embedded in paraffin.

Alterations during Positive Selection in the Thymus of nackt CD4-Deficient Mice

2000 ◽  
Vol 52 (6) ◽  
pp. 555-562 ◽  
Author(s):  
I. Nepomnaschy ◽  
G. Lombardi ◽  
P. Bekinschtein ◽  
P. Berguer ◽  
V. Francisco ◽  
...  
Keyword(s):  
Positive Selection ◽  
Deficient Mice

Gubernacular development in Müllerian inhibiting substance receptor-deficient mice

2002 ◽  
Vol 89 (1) ◽  
pp. 113-118 ◽  
Author(s):  
J.E. Bartlett ◽  
S.M.Y. Lee ◽  
Y. Mishina ◽  
R.R. Behringer ◽  
N. Yang ◽  
...  
Keyword(s):  
Müllerian Inhibiting Substance ◽  
Deficient Mice ◽  
Mullerian Inhibiting Substance

Characterization of Helicobacter-induced inflammatory bowel disease in IL-10 -/- and T cell deficient mice

2001 ◽  
Vol 120 (5) ◽  
pp. A523-A523
Author(s):  
A BURICH ◽  
R HERSHBERG ◽  
K WAGGIE ◽  
W ZENG ◽  
J VINEY ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
T Cell ◽  
Bowel Disease ◽  
Inflammatory Bowel ◽  
Deficient Mice

Different effects of chronic helicobactor pylori infection on parietal and ECL cells between wild type and gastrin-deficient mice

2001 ◽  
Vol 120 (5) ◽  
pp. A728-A728
Author(s):  
D CHEN ◽  
L FRIISHANSEN ◽  
X WANG ◽  
C ZHAO ◽  
H WALDUM ◽  
...  
Keyword(s):  
Wild Type ◽  
Ecl Cells ◽  
Helicobactor Pylori ◽  
Deficient Mice
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