scholarly journals 0689 Use Of An Automated Scanning System To Select A Patient Interface

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A263-A263
Author(s):  
W Hardy ◽  
J Jasko ◽  
R Bogan
Keyword(s):  
Selection Process ◽  
Three Dimensional ◽  
Controlled Study ◽  
Adherence Rate ◽  
Scanning System ◽  
3D Scanner ◽  
Open Label ◽  
Sleep Centers ◽  
Automated Scanning ◽  
The Impact

Abstract Introduction There is no universal process for selecting mask style, size, and fit, and there is considerable variance in clinician and patient mask preference and patient anatomy. Poor mask fit may negatively affect adherence. A three-dimensional (3D) facial scanner and proprietary analytical software were developed to bring efficiencies to mask selection. This study explored the impact of that system on initial mask success compared to standard practice. Methods This was an open-label, randomized-controlled study. Participants provided written informed consent. 3D Scanner Arm (3DA): Participants answered questions about sleeping habits then had 3D facial images taken. Proprietary software recommended a hierarchy of up to four Philips Respironics masks and sizes. Traditional Fitting Arm (TFA): A designated clinician selected and fit masks using their standard methods. Mask selection was assessed by applying therapy and soliciting patient and clinician feedback. Mask refits and adherence were tracked through 90 days. Five sleep centers recruited 115 participants into the 3DA (61 males, 51.1±13.4 years, BMI 35.2±7.0, diagnostic AHI 26.2±21.9) and 123 into the TFA (79 males, 51.1±11.9 years, BMI 35±7.9, diagnostic AHI 26.9±22.6). Results A significantly higher percentage of 3DA patients required only one mask fitting (with no refits) compared to TFA during the initial setup (89.6% vs. 54.5%, p<0.001) and through 90 days (62.6% vs 37.4%, p<0.001). 3DA subjectively rated confidence in and satisfaction with the scanner-selected mask significantly higher than TFA. Mask leak was lower in the 3DA compared to TFA (29.4±10.6 vs 32.3±11.4 L/M, p= 0.043). The CMS adherence rate tended to favor 3DA vs. TFA (66.7% vs. 55.3, p=0.083). There were no significant differences in AHI or other adherence metrics. Conclusion The 3D scanner system was successful in mask selection with lower mask leak and greater patient satisfaction and confidence. This tool may bring about operational efficiencies to the mask selection process. Support This study was sponsored by Philips Respironics

The Impact of Example Modality and Physical Interactions on Design Creativity

2014 ◽  
Vol 136 (9) ◽  
Author(s):  
Christine A. Toh ◽  
Scarlett R. Miller
Keyword(s):  
Engineering Design ◽  
Three Dimensional ◽  
Idea Generation ◽  
Controlled Study ◽  
First Year ◽  
Design Creativity ◽  
Physical Interactions ◽  
2D And 3D ◽  
The Impact

Interacting with example products is an essential and widely practiced method in engineering design, yet little information exists on how the representation (pictorial or physical) or interaction a designer has with an example impacts design creativity. This is problematic because without this knowledge we do not understand how examples affect idea generation or how we can effectively modify or develop design methods to support example usage practices. In this paper, we report the results of a controlled study with first year engineering design students (N = 89) developed to investigate the impact of a designer's interaction with either a two-dimensional (2D) pictorial image or a three-dimensional (3D) product (through visual inspection or product dissection activities) and the resulting functional focus and creativity of the ideas developed. The results of this study reveal that participants who interacted with the physical example produced ideas that were less novel and less functionally focused than those who interacted with the 2D representation. Additionally, the results showed that participants who dissected the product produced a higher variety of ideas than those that visually inspected it. These results contribute to our understanding of the benefits and role of 2D and 3D designer-product interactions during idea development. We use these findings to develop recommendations for the use of designer-product interactions throughout the design process.

scholarly journals Auxora Versus Standard of Care For The Treatment of Severe or Critical COVID-19 Pneumonia: Results From A Randomized Controlled Trial

2020 ◽  
Author(s):  
Joseph Miller ◽  
Charles Bruen ◽  
Michael Schnaus ◽  
Jeffrey Zhang ◽  
Sadia Ali ◽  
...  
Keyword(s):  
Standard Of Care ◽  
Ordinal Scale ◽  
Controlled Study ◽  
Respiratory Complications ◽  
Open Label ◽  
Open Label Study ◽  
Label Study ◽  
Randomized Controlled ◽  
Crac Channel ◽  
The Impact

Abstract BACKGROUND: Calcium release-activated calcium (CRAC) channel inhibitors stabilize the pulmonary endothelium and block proinflammatory cytokine release, potentially mitigating respiratory complications observed in patients with COVID-19. This study aimed to investigate the safety and efficacy of Auxora, a novel, intravenously administered CRAC channel inhibitor, in adults with severe or critical COVID-19 pneumonia METHODS: A randomized, controlled, open-label study of Auxora was conducted in adults with severe or critical COVID-19 pneumonia. Patients were randomized 2:1 to receive three doses of once-daily Auxora versus standard of care (SOC) alone. The primary objective was to assess safety and tolerability of Auxora. Following FDA guidance, study enrollment was halted early to allow for transition to a randomized, blinded, placebo-controlled study. RESULTS: In total, 17 patients with severe and three with critical COVID-19 pneumonia were randomized to Auxora and nine with severe and one with critical COVID-19 pneumonia to SOC. Similar proportions of patients receiving Auxora and SOC experienced ≥1 adverse event (75% versus 80%, respectively). Fewer patients receiving Auxora experienced serious adverse events versus SOC (30% versus 50%, respectively). Two patients (10%) receiving Auxora and two (20%) receiving SOC died in the 30 days after randomization. Among patients with severe COVID-19 pneumonia, median time to recovery with Auxora was five days versus 12 days with SOC; recovery rate ratio was 1.87 (95%CI, 0.72, 4.89). Invasive mechanical ventilation was needed in 18% of patients with severe COVID-19 pneumonia receiving Auxora versus 50% receiving SOC (absolute risk reduction=32%; 95%CI, -0.07, 0.71). Outcomes measured by an 8-point ordinal scale were significantly improved for patients receiving Auxora, especially for patients with a baseline PaO2/FiO2=101-200. CONCLUSIONS: Auxora demonstrated a favorable safety profile in patients with severe or critical COVID-19 pneumonia and improved outcomes in patients with severe COVID-19 pneumonia. These results, however, are limited by the open-label study design and small patient population resulting from early cessation of enrollment in response to regulatory guidance. The impact of Auxora on respiratory complications in patients with severe COVID-19 pneumonia will be further assessed in a planned randomized, blinded, placebo-controlled study. Trial registration: ClinicalTrials.gov, NCT04345614. Submitted 7April2020 - https://clinicaltrials.gov/ct2/show/NCT04345614

scholarly journals Auxora Versus Standard of Care For The Treatment of Severe or Critical COVID-19 Pneumonia: Results From A Randomized Controlled Trial

2020 ◽  
Author(s):  
Joseph Miller ◽  
Charles Bruen ◽  
Michael Schnaus ◽  
Jeffrey Zhang ◽  
Sadia Ali ◽  
...  
Keyword(s):  
Standard Of Care ◽  
Ordinal Scale ◽  
Controlled Study ◽  
Respiratory Complications ◽  
Open Label ◽  
Open Label Study ◽  
Label Study ◽  
Randomized Controlled ◽  
Crac Channel ◽  
The Impact

Abstract BACKGROUND: Calcium release-activated calcium (CRAC) channel inhibitors stabilize the pulmonary endothelium and block proinflammatory cytokine release, potentially mitigating respiratory complications observed in patients with COVID-19. This study aimed to investigate the safety and efficacy of Auxora, a novel, intravenously administered CRAC channel inhibitor, in adults with severe or critical COVID-19 pneumonia METHODS: A randomized, controlled, open-label study of Auxora was conducted in adults with severe or critical COVID-19 pneumonia. Patients were randomized 2:1 to receive three doses of once-daily Auxora versus standard of care (SOC) alone. The primary objective was to assess safety and tolerability of Auxora. Following FDA guidance, study enrollment was halted early to allow for transition to a randomized, blinded, placebo-controlled study. RESULTS: In total, 17 patients with severe and three with critical COVID-19 pneumonia were randomized to Auxora and nine with severe and one with critical COVID-19 pneumonia to SOC. Similar proportions of patients receiving Auxora and SOC experienced ≥1 adverse event (75% versus 80%, respectively). Fewer patients receiving Auxora experienced serious adverse events versus SOC (30% versus 50%, respectively). Two patients (10%) receiving Auxora and two (20%) receiving SOC died in the 30 days after randomization. Among patients with severe COVID-19 pneumonia, median time to recovery with Auxora was five days versus 12 days with SOC; recovery rate ratio was 1.87 (95%CI, 0.72, 4.89). Invasive mechanical ventilation was needed in 18% of patients with severe COVID-19 pneumonia receiving Auxora versus 50% receiving SOC (absolute risk reduction=32%; 95%CI, -0.07, 0.71). Outcomes measured by an 8-point ordinal scale were significantly improved for patients receiving Auxora, especially for patients with a baseline PaO2/FiO2=101-200. CONCLUSIONS: Auxora demonstrated a favorable safety profile in patients with severe or critical COVID-19 pneumonia and improved outcomes in patients with severe COVID-19 pneumonia. These results, however, are limited by the open-label study design and small patient population resulting from early cessation of enrollment in response to regulatory guidance. The impact of Auxora on respiratory complications in patients with severe COVID-19 pneumonia will be further assessed in a planned randomized, blinded, placebo-controlled study. Trial registration: ClinicalTrials.gov, NCT04345614. Submitted 7April2020 - https://clinicaltrials.gov/ct2/show/NCT04345614

scholarly journals Simulation of Multi-Camera Indoor and Outdoor 3D Scanner

2018 ◽  
Vol 2 (3) ◽  
pp. 33-41
Author(s):  
Keyword(s):  
Three Dimensional ◽  
System Structure ◽  
3D Scanner ◽  
Background Removal ◽  
Dimensional Reconstruction ◽  
Characteristic Points ◽  
Graphic Engine ◽  
The Impact ◽  
Indoor And Outdoor

Photogrammetry allows a three-dimensional reconstruction of the object based on its multiple photography’s. The quality of the reconstruction result depends mostly on the gloss, the diversity of the texture, the lighting conditions, the quality of the camera calibration and the shape of the object. The article presents the results of a simulation of a multi-camera reconstruction system, for the needs of designing indoor and outdoor 3D scanner. The 3D reconstruction system works by simultaneously taking photographs of cameras located around the object. The simulation was created to investigate the optimal distribution of cameras and projectors casting a pattern that increases the number of characteristic points on the surface of the object. The impact of background removal in images on the reconstruction result as well as the texture quality of the object depending on the resolution and distance of the cameras from the object were also investigated. The graphic engine used to create the simulation also allows testing of impact of various conditions. The presented results prove that the parameters of the system structure, such as the placement of cameras, projectors, the selection of patterns projected by the projectors are important and their values can be determined at the stage of system simulation. The acquired results are promising and will be further investigated.

scholarly journals Dimensional changes of dental arches produced by fixed and removable palatal cribs: A prospective, randomized, controlled study

2016 ◽  
Vol 87 (2) ◽  
pp. 215-222 ◽  
Author(s):  
Thiago Slaviero ◽  
Thais Maria Freire Fernandes ◽  
Paula Vanessa Pedron Oltramari-Navarro ◽  
Ana Claudia de Castro ◽  
Ferreira Conti ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Open Bite ◽  
Mixed Dentition ◽  
Controlled Study ◽  
3D Scanner ◽  
Anterior Open Bite ◽  
Treatment Protocols ◽  
Mandibular Incisor ◽  
Dimensional Changes ◽  
3D Software

ABSTRACT Objective: To evaluate the dimensional changes of dental arches on digital models of open bite treatment with fixed and removable palatal cribs. Materials and Methods: The sample comprised 41 patients of both sexes who were white, aged 7–10 years, and who had mixed dentition, Angle Class I molar relationship, and a negative overbite of at least 1 mm. The sample was randomly divided into two groups: G1, fixed palatal crib; and G2, removable palatal crib. Cast models, obtained initially (T1) and after 1 year of treatment (T2), were scanned by a three-dimensional (3D) scanner, 3Shape R700, producing a 3D image. Measurements were performed by a calibrated examiner using OrthoAnalyzer™ 3D software. Results: At T2–T1, differences were observed between the groups regarding vertical dentoalveolar development and overjet. There was more mandibular incisor extrusion for G1 (−1.66 mm) than for G2 (−0.54 mm). An overjet increase was observed in G1 (0.56 mm), in contrast to a reduction in G2 (−0.40 mm). There was a similar overbite increase for both groups (3.51 mm for fixed palatal crib and 3.88 mm for removable palatal crib). Conclusions: Both the treatment protocols are similarly effective for anterior open bite correction, providing an overbite increase with dentoalveolar arch changes, especially in the anterior region.

scholarly journals Underwater High-Precision 3D Reconstruction System Based on Rotating Scanning

Sensors ◽  
2021 ◽  
Vol 21 (4) ◽  
pp. 1402
Author(s):  
Qingsheng Xue ◽  
Qian Sun ◽  
Fupeng Wang ◽  
Haoxuan Bai ◽  
Bai Yang ◽  
...  
Keyword(s):  
3D Reconstruction ◽  
High Precision ◽  
Laser Scanning ◽  
Low Cost ◽  
Three Dimensional ◽  
Reconstruction Error ◽  
Scanning System ◽  
Standard Sphere ◽  
Underwater Camera ◽  
The Impact

This paper presents an underwater high-precision line laser three-dimensional (3D) scanning (LLS) system with rotary scanning mode, which is composed of a low illumination underwater camera and a green line laser projector. The underwater 3D data acquisition can be realized in the range of field of view of 50° (vertical) × 360° (horizontal). We compensate the refraction of the 3D reconstruction system to reduce the angle error caused by the refraction of light on different media surfaces and reduce the impact of refraction on the image quality. In order to verify the reconstruction effect of the 3D reconstruction system and the effectiveness of the refraction compensation algorithm, we conducted error experiments on a standard sphere. The results show that the system’s underwater reconstruction error is less than 0.6 mm within the working distance of 140 mm~2500 mm, which meets the design requirements. It can provide reference for the development of low-cost underwater 3D laser scanning system.

An Automatic Calibration Method in the Crop Architecture 3D Scanner

2011 ◽  
Vol 204-210 ◽  
pp. 493-497
Author(s):  
Sheng Yong Xu ◽  
De Hua Li ◽  
Zhu Li ◽  
Qing Wei
Keyword(s):  
Three Dimensional ◽  
Calibration Method ◽  
Reference Points ◽  
Scanning System ◽  
Automatic Calibration ◽  
Automatic Method ◽  
Essential Work ◽  
3D Scanner ◽  
Average Value ◽  
Calibration Parameters

Calibration is an essential work in three-dimensional scanning system. The operation of existing calibration is complex and tedious. In this paper, we design a DLT-based automatic method of calibration, in which the calibration reference points are detected automatically. Then we can figure out a series of calibration parameters from these points. The average value of all parameters is just the calibration parameters. The experimental results show that the method we proposed is not only guaranteeing the calibration precision but also simplifying the calibration operation comparing with the traditional manual calibration method.

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