Effects Of Exogenous Melatonin On Sleep And Circadian Rhythms In Women With Premenstrual Dysphoric Disorder

SLEEP ◽  
2021 ◽  
Author(s):  
Christophe Moderie ◽  
Philippe Boudreau ◽  
Ari Shechter ◽  
Paul Lesperance ◽  
Diane B Boivin
Keyword(s):  
Menstrual Cycle ◽  
Slow Wave Sleep ◽  
Core Body Temperature ◽  
Premenstrual Dysphoric Disorder ◽  
Ovarian Hormones ◽  
Exogenous Melatonin ◽  
Plasma Melatonin ◽  
Menstrual Symptoms ◽  
The Impact ◽  
Intervention Condition

Abstract We previously found normal polysomnographic (PSG) sleep efficiency, increased slow wave sleep (SWS) and a blunted melatonin secretion in women with premenstrual dysphoric disorder (PMDD) compared to controls. Here, we investigated the effects of exogenous melatonin in five patients previously studied. They took 2 mg of slow-release melatonin 1 hour before bedtime during their luteal phase (LP) for three menstrual cycles. At baseline, patients spent every third night throughout one menstrual cycle sleeping in the laboratory. Measures included morning urinary 6-sulfatoxymelatonin (aMt6), PSG sleep, nocturnal core body temperature (CBT), visual analogue scale for mood (VAS-Mood), Prospective Record of the Impact and Severity of Menstrual Symptoms (PRISM), and ovarian hormones. Participants also underwent two 24-hour intensive physiological monitoring (during the follicular phase and LP) in time-isolation/constant conditions to determine 24-hour plasma melatonin and CBT rhythms. The same measures were repeated during their third menstrual cycle of melatonin administration. In the intervention condition compared to baseline, we found increased urinary aMt6 (p<0.001), reduced objective SOL (p=0.01), reduced SWS (p<0.001) and increased Stage 2 sleep (p<0.001). Increased urinary aMt6 was associated with reduced SWS (r=-0.51, p<0.001). Circadian parameters derived from 24-hour plasma melatonin and CBT did not differ between conditions, except for an increased melatonin mesor in the intervention condition (p=0.01). Ovarian hormones were comparable between the conditions (p≥0.28). Symptoms improved in the intervention condition, as measured by the VAS-Mood (p=0.02) and the PRISM (p<0.001). These findings support a role for disturbed melatonergic system in PMDD that can be partially corrected by exogenous melatonin.

738 Effects of exogenous melatonin on sleep, circadian rhythms, and mood in women with premenstrual dysphoric disorder

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A288-A288
Author(s):  
Christophe Moderie ◽  
Ari Shechter ◽  
Paul Lespérance ◽  
Diane Boivin
Keyword(s):  
Menstrual Cycle ◽  
Sleep Disturbances ◽  
Slow Wave Sleep ◽  
Premenstrual Dysphoric Disorder ◽  
Ovarian Hormones ◽  
Exogenous Melatonin ◽  
Plasma Melatonin ◽  
Menstrual Symptoms ◽  
The Impact ◽  
Intervention Condition

Abstract Introduction Most women with premenstrual dysphoric disorder (PMDD) report sleep disturbances. Our group found normal polysomnographic (PSG) sleep efficiency and increased slow wave sleep (SWS) across the menstrual cycle in women with PMDD and insomnia compared to controls. Reduced melatonin levels were found in PMDD women compared to controls, with reduced secretion during their luteal phase (LP) compared to follicular phase (FP). Here, we investigated the effects of exogenous melatonin in the patients we previously studied. Methods Five patients (age, mean: 33.6, SD: 2.7) diagnosed prospectively with PMDD and insomnia participated in the study. Following a baseline assessment, patients took 2 mg of slow-release melatonin 1h before bedtime during their LP for three consecutive menstrual cycles. At baseline (treatment-free condition), patients spent every third night of their menstrual cycle sleeping in the laboratory. Measures included morning urinary 6-sulfatoxymelatonin (aMt6), PSG sleep, nocturnal core body temperature (CBT), visual analogue scale for mood (VAS-Mood), Prospective Record of the Impact and Severity of Menstrual symptoms (PRISM), subjective sleep and ovarian hormones (estrogen and progesterone). Participants also underwent two 24-hour intensive physiological monitoring (during the FP and LP) in time-isolation/constant conditions to determine 24-hour plasma melatonin and CBT rhythms. The same measures were repeated during their third menstrual cycle of melatonin administration. Results In the intervention condition compared to baseline, we found increased urinary aMt6 (p<0.001), reduced objective SOL (p=0.01), SWS (p<0.001) and increased Stage 2 sleep (p<0.001). Increased urinary aMt6 was associated with reduced SWS (r=-0.51, p<0.001). Circadian parameters derived from 24-hour plasma melatonin and CBT did not differ between conditions, except for an increased melatonin mesor in the intervention condition (p=0.01). Ovarian hormones were comparable between the conditions (p≥0.28). Symptoms improved in the intervention condition, as measured by the VAS-Mood (p=0.02) and the PRISM (p<0.001). Conclusion We have shown normalization of SWS and reduction in self-reported mood and somatic symptoms after administrating exogenous melatonin in women with PMDD. These findings support a role for disturbed melatoninergic system in PMDD that can be partially corrected by exogenous melatonin. Support (if any) This study was supported by the Canadian Institutes of Health Research (CIHR)

Australian female athlete perceptions of the challenges associated with training and competing when menstrual symptoms are present

2020 ◽  
Vol 15 (3) ◽  
pp. 316-323
Author(s):  
Mike Armour ◽  
Kelly A Parry ◽  
Kylie Steel ◽  
Caroline A Smith
Keyword(s):  
Menstrual Cycle ◽  
Contraceptive Use ◽  
Negative Impact ◽  
Management Strategies ◽  
Chi Square ◽  
Contraceptive Usage ◽  
Menstrual Symptoms ◽  
Potential Risks ◽  
Potential Impact ◽  
The Impact

Coaches consider various competencies (e.g. conditioning, nutrition, skills and tactics), when planning sessions, though rarely the impact of menstruation on the efficacy of training and competition performance for athletes. Given the impact menstrual symptoms can have on athletes, the management strategies that athletes may use to minimise any potential impact, and the mechanisms that provide barriers to greater coach athlete interaction require investigation and consideration. Therefore, this study aimed to investigate the strategies used by athletes to manage menstrual symptoms and the role coaches played in this process. An anonymous, 36-item questionnaire was developed and hosted on Qualtrics. Descriptive statistics and Chi-square statistics were used to analyse the data. One hundred and twenty-four valid responses from Australian athletes 16–45, with a mean age of 29 years, were received. Period pain (82%) and pre-menstrual symptoms (83%) were commonly reported and contributed to fatigue and to perceived reductions in performance during or just prior to the period (50.0% in training, 58.7% on ‘game day’). Contraceptive use was reported by 42% of athletes. Those reporting heavy menstrual bleeding (29.7%) were more likely to report increased fatigue (relative risk 1.6, 95% CI 1.07 to 2.32). Over three-quarters of athletes reported neither they nor their coaches altered training due to the menstrual cycle. Most athletes (76%) did not discuss menstruation with their coaches. Given the perceived negative impact on performance and potential risks with contraceptive usage during adolescence, coaches, trainers and athletes need to have a more open dialogue around the menstrual cycle.

scholarly journals Systematic and Meta-Analytic Review of Research Examining the Impact of Menstrual Cycle Phase and Ovarian Hormones on Smoking and Cessation

2015 ◽  
Vol 17 (4) ◽  
pp. 407-421 ◽  
Author(s):  
A. H. Weinberger ◽  
P. H. Smith ◽  
S. S. Allen ◽  
K. P. Cosgrove ◽  
M. E. Saladin ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Ovarian Hormones ◽  
Cycle Phase ◽  
Menstrual Cycle Phase ◽  
Analytic Review ◽  
The Impact

Characteristics of the menstrual cycle in 13-year-old Flemish girls and the impact of menstrual symptoms on social life

2015 ◽  
Vol 175 (5) ◽  
pp. 623-630 ◽  
Author(s):  
Karel Hoppenbrouwers ◽  
Mathieu Roelants ◽  
Christel Meuleman ◽  
Anna Rijkers ◽  
Karla Van Leeuwen ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Social Life ◽  
Menstrual Symptoms ◽  
The Impact

scholarly journals The impact of competitive sports on menstrual cycle and menstrual disorders, including premenstrual syndrome, premenstrual dysphoric disorder and hormonal imbalances

2020 ◽  
Vol 91 (9) ◽  
pp. 503-512
Author(s):  
Mariola Czajkowska ◽  
Agnieszka Drosdzol-Cop ◽  
Beata Naworska ◽  
Iwona Galazka ◽  
Celina Gogola ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Premenstrual Syndrome ◽  
Premenstrual Dysphoric Disorder ◽  
Competitive Sports ◽  
Menstrual Disorders ◽  
The Impact

Is a Little (Psychiatric) Knowledge a Dangerous Thing?: The Impact of Premenstrual Dysphoric Disorder on Perceptions of Premenstrual Women

1997 ◽  
Vol 21 (2) ◽  
pp. 315-322 ◽  
Author(s):  
Heather C. Nash ◽  
Joan C. Chrisler
Keyword(s):  
Menstrual Cycle ◽  
American Psychiatric Association ◽  
Premenstrual Dysphoric Disorder ◽  
Chi Square ◽  
Statistical Manual ◽  
Diagnostic And Statistical Manual ◽  
Women’S Perceptions ◽  
Dsm Iv ◽  
Menstrual Distress ◽  
The Impact

One hundred thirty-four participants completed a revised Menstrual Distress Questionnaire (MDQ), which included criteria for premenstrual dysphoric disorder (PMDD). Two weeks later the participants again completed the revised MDQ after reading either the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV; American Psychiatric Association, 1994) diagnostic criteria for the PMDD or a copy of the same criteria retitled “Episodic Dysphoric Disorder,” with all menstrual cycle references removed. Knowledge of the diagnosis did not affect women's perceptions of their own menstrual cycle-related symptoms, but it increased participants' perceptions of premenstrual changes as a problem for women in general. Chi-square analyses revealed that participants were more willing to attach a psychiatric diagnosis to women they know if they believed the diagnosis was related to the menstrual cycle.

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