scholarly journals Effect of prenatal exposure to TCDD on the promotion of endometriotic lesion growth by TCDD in adult female rats and mice

1999 ◽  
Vol 52 (1) ◽  
pp. 45-49 ◽  
Author(s):  
A. Cummings
Keyword(s):  
Prenatal Exposure ◽  
Adult Female ◽  
Female Rats ◽  
Endometriotic Lesion ◽  
Lesion Growth ◽  
Rats And Mice

scholarly journals SAT-717 Region-Specific Effects of the Exposome on Brain Monoamine Levels in Female Rats

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Amrita Kaimal ◽  
Jessica Hooversmith ◽  
Maryam H Al Mansi ◽  
Philip V Holmes ◽  
Sheba M J MohanKumar ◽  
...  
Keyword(s):  
Prenatal Exposure ◽  
Adult Female ◽  
High Performance ◽  
Endocrine Disrupting Chemicals ◽  
Female Offspring ◽  
Female Rats ◽  
Saline Control ◽  
Estradiol Treatment ◽  
Specific Effects ◽  
End Of Treatment

Abstract Prenatal programming with endocrine disrupting chemicals (EDCs), in particular the ubiquitous plasticizers bisphenol A (BPA) and di(2-ethylhexyl) phthalate (DEHP), can induce long-lasting behavioral changes in rats. Additionally, changes in estrogen are correlated with the development of mood disorders in women; however, the underlying neurobiological mechanisms are unclear. This study was conducted to determine the cumulative effects of prenatal exposure to EDCs followed by chronic estradiol treatment in adult female rats on monoamine levels in the prefrontal cortex (PFC) and hippocampus (HC). Dams were orally administered saline (control; 10 µL/kg), BPA (B; 5 µg/kg), DEHP (D; 7.5 mg/kg) or a combination of BPA+DEHP (B+D) during days 6 through 21 of pregnancy. Adult female offspring were sham-implanted or implanted with pellets that release 17β-estradiol (E2) for 90 days (20 ng/day; Innovative Research America). The offspring then underwent a battery of behavioral tests at the end of treatment. Brains collected from the offspring were sectioned and the PFC and HC were microdissected and analyzed for levels of norepinephrine (NE), dopamine (DA) and serotonin (5-HT), using High-Performance Liquid Chromatography (HPLC). Significant reductions in monoamine levels were observed in the PFC while NE and 5-HT levels were markedly reduced in the HC after prenatal exposure to D or BD. BPA’s effects on monoamines were comparatively modest. E2 exposure increased DA but decreased 5-HT levels in the PFC of control animals. Prenatal exposure to EDCs made the offspring non-responsive to E2. The marked reduction in monoamine levels could have implications for learning and memory.

OBSERVATIONS ON A DITHIOCARBAMOYLHYDRAZINE AS AN INHIBITOR OF PITUITARY GONADOTROPHIC ACTIVITY

1963 ◽  
Vol 26 (3) ◽  
pp. 425-436 ◽  
Author(s):  
P. S. BROWN
Keyword(s):  
Adult Female ◽  
General Condition ◽  
Follicle Stimulating Hormone ◽  
Specific Effect ◽  
Female Rats ◽  
Male Rats ◽  
Pituitary Glands ◽  
Rats And Mice ◽  
Intact Rats ◽  
Stimulating Hormone

SUMMARY A dithiocarbamoylhydrazine (ICI 33828) was injected s.c. into intact rats and mice. It usually caused a reduction in weight of the uterus or of the accessory organs in the male, but less commonly of the gonads. As little as 0·5 mg. daily for 4 days caused significant effects in adult female rats, while half this dose on alternate days retarded maturation in male rats. ICI 33828 was injected with exogenous gonadotrophin in three systems of assay and in some cases it modified the response to the gonadotrophin. This may not be due to a specific effect at the gonadal level but either to suppression of endogenous gonadotrophins in the test animals or to the effect of ICI 33828 on their general condition. Pituitary glands from male rats treated with ICI 33828 were assayed for follicle stimulating hormone (FSH) and found to contain significantly less than glands from control rats. This suggests that ICI 33828 acts by reducing the formation of pituitary gonadotrophin.

scholarly journals Effect of Methamphetamine on Cognitive Functions of Adult Female Rats Prenatally Exposed to the Same Drug

2013 ◽  
pp. S89-S98 ◽  
Author(s):  
E. MACÚCHOVÁ ◽  
K. NOHEJLOVÁ-DEYKUN ◽  
R. ŠLAMBEROVÁ
Keyword(s):  
Estrous Cycle ◽  
Prenatal Exposure ◽  
Adult Female ◽  
Cognitive Functions ◽  
Female Rats ◽  
Saline Control ◽  
Control Group ◽  
Prenatally Exposed ◽  
Place Navigation ◽  
Navigation Test

The aim of this study was to investigate the effect of prenatal methamphetamine (MA) exposure and application of the same drug in adulthood on cognitive functions of adult female rats. Animals were prenatally exposed to MA (5 mg/kg) or saline (control group). The cognitive function was tested as ability of spatial learning in the Morris Water Maze (MWM). Each day of the experiment animals received an injection of MA (1 mg/kg) or saline. Our results demonstrated that prenatal MA exposure did not affect the latency to reach the hidden platform or the distance traveled during the Place Navigation Test; however, the speed of swimming was increased in prenatally MA-exposed rats compared to controls regardless of the treatment in adulthood. MA treatment in adulthood increased the latency and distance when compared to controls regardless of the prenatal exposure. Neither prenatal exposure, nor treatment in adulthood affected memory retrieval. As far as the estrous cycle is concerned, our results showed that prenatally MA-exposed females in proestrus/estrus swam faster than females in diestrus. This effect of estrous cycle was not apparent in control females. In conclusion, our results indicate that postnatal, but not prenatal exposure to MA affects learning of adult female rats.

CORTICOSTEROID-UMSATZ UND CORTICOSTEROID-PRODUKTION BEI RATTEN UNTER DER BEHANDLUNG MIT ANABOLEN STEROIDEN

1965 ◽  
Vol 48 (2) ◽  
pp. 263-271 ◽  
Author(s):  
Herbert Schriefers ◽  
Gerlinde Scharlau ◽  
Franzis Pohl
Keyword(s):  
Production Rate ◽  
Adult Female ◽  
Anabolic Steroids ◽  
Reduction Rate ◽  
Female Rats ◽  
Adrenal Weight ◽  
Hydrogenase Activity ◽  
Anabolic Effect ◽  
Liver Slices

ABSTRACT After the administration of anabolic steroids to adult female rats in daily doses of 1 mg per animal for 14 days, the following parameters were investigated: the rate of the Δ4-5α-hydrogenase-catalyzed cortisone reduction in liver slices and microsomal fractions, the adrenal weight and the in vitro corticosterone production rate. Among the steroids tested, only 17α-methyl-testosterone and 17α-ethyl-19-nor-testosterone were effective in lowering significantly cortisone reduction rate by liver slices with concomitant decreases in microsomal Δ4-5α-hydrogenase-activity. Testosterone, 19-nor-testosterone, 17α-ethinyl-19-nor-testosterone, 17α-methyl-17β-hydroxy-androsta-1,4-dien-3-one and 1-methyl-17β-hydroxy-androst-1-en-3-one were ineffective or only slightly effective. Adrenal weight and absolute corticosterone production rate (μg/60 min per animal) were decreased after treatment with 17α-methyl-testosterone, 17α-ethyl-19-nor-testosterone and 1-methyl-17β-hydroxy-androst-1-en-3-one. Corticosterone production was decreased with 17α-ethinyl-19-nor-testosterone in spite of an unchanged adrenal weight. The relative corticosterone production rate (μg/60 min · 100 mg adrenal) was in any cases unaffected. According to these results there exists – with the exception of 17α-ethinyl-19-nor-testosterone – a strict parallelism between corticosteroid turnover and corticosterone production rate: unchanged turnover is correlated with unchanged corticosterone production rate, while a decreased turnover is correlated with decreased adrenal activity. The protein-anabolic effect of certain anabolic steroids may be partly due to an anti-catabolic action of these compounds resulting from a decreased corticosteroid inactivation and production rate. Possible mechanisms by which anabolic steroids may affect corticosteroid-balance are discussed.

THE HYPOTHALAMUS AND PROPYLTHIOURACIL-INDUCED GOITRE IN THE RAT

1963 ◽  
Vol 42 (2) ◽  
pp. 254-262 ◽  
Author(s):  
J. J. van der Werff ten Bosch ◽  
H. E. Swanson
Keyword(s):  
Steady State ◽  
Thyroid Hormone ◽  
Adult Female ◽  
Normal Diet ◽  
Anterior Hypothalamus ◽  
Female Rats ◽  
Intact Rats

ABSTRACT Adult female rats were given a normal diet, or a diet which contained 0.15% propylthiouracil. At the beginning of the experiment one half of the rats were left intact, whilst the others received an electrolytic basal midline lesion in the anterior hypothalamus. Of each of the four groups of rats, one half was killed after 14 days, the others after 28 days. It was found (both after 14 and after 28 days) that the presence of a lesion reduced the thyroid weight to approximately 75% of the value in intact rats on the same diet, which might be normal or contain propylthiouracil. Propylthiouracil caused thyroid enlargement (to 278% after 14 days and 352–360% after 28 days) in intact rats as compared with intact rats on a normal diet, and in lesioned rats as compared with lesioned rats on a normal diet. It is concluded that lesions cause a lowered steady state of the thyroid-pituitary feed-back system, but that this system responds normally to the alteration of the steady state caused by the propylthiouracil-induced block in thyroid hormone output.

BEFUNDE AM GENITALTRAKTUS DER RATTE NACH CORTICOTROPIN-INJECTION UND IHRE DEUTUNG UNTER BERÜCKSICHTIGUNG DES ZELLBILDES DER ADENOHYPOPHYSE

1959 ◽  
Vol XXXII (II) ◽  
pp. 167-176 ◽  
Author(s):  
Walter Schätzle
Keyword(s):  
Adult Female ◽  
Single Injection ◽  
Anterior Lobe ◽  
Vaginal Epithelium ◽  
Female Rats ◽  
Normal Adult ◽  
List Type

ABSTRACT In normal adult female rats a single injection of 5 IU corticotrophin was followed by a retention of glucoproteid material in the anterior lobe of the hypophysis and by impairment of the luteinization. In spayed adult female rats the same corticotrophin administration caused stratification and mucification of the vaginal epithelium.

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