scholarly journals Curcumin Reverses Methylglyoxal Induced Apoptosis in RINm5F Cells and PC12 Cells in Hyperglycemic Conditions

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Shaima Fazal Patangia ◽  
Sue Mungre
Keyword(s):  
Pc12 Cells ◽  
Rinm5f Cells ◽  
Induced Apoptosis

scholarly journals New Cyclic Diarylheptanoids from Platycarya strobilacea

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 6034
Author(s):  
Wen-bing Ding ◽  
Rui-yuan Zhao ◽  
Guan-hua Li ◽  
Bing-lei Liu ◽  
Hua-liang He ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Pc12 Cells ◽  
Stem Bark ◽  
No Production ◽  
Electronic Circular Dichroism ◽  
Pheochromocytoma Pc12 ◽  
Pheochromocytoma Pc12 Cells ◽  
Induced Apoptosis ◽  
Circular Dichroïsm

Five new cyclic diarylheptanoids (platycary A–E, compounds 1–5) and three previously identified analogues (i.e., phttyearynol (compound 6), myricatomentogenin (compound 7), and juglanin D (compound 8)) were isolated from the stem bark of Platycarya strobilacea. The structures of these compounds were determined using NMR, HRESIMS, and electronic circular dichroism (ECD) data. The cytotoxicity of compounds 1–5 and their ability to inhibit nitric oxide (NO) production, as well as protect against the corticosterone-induced apoptosis of Pheochromocytoma (PC12) cells, were evaluated in vitro using the appropriate bioassays. Compounds 1 and 2 significantly inhibited the corticosterone-induced apoptosis of PC12 cells at a concentration of 20 μΜ.

Marein protects against methylglyoxal-induced apoptosis by activating the AMPK pathway in PC12 cells

2016 ◽  
Vol 50 (11) ◽  
pp. 1173-1187 ◽  
Author(s):  
Baoping Jiang ◽  
Liang Le ◽  
Haibo Liu ◽  
Lijia Xu ◽  
Chunnian He ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Ampk Pathway ◽  
Induced Apoptosis

scholarly journals Isorhynchophylline Protects PC12 Cells Against Beta-Amyloid-Induced Apoptosis via PI3K/Akt Signaling Pathway

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Yan-Fang Xian ◽  
Zhi-Xiu Lin ◽  
Qing-Qiu Mao ◽  
Jian-Nan Chen ◽  
Zi-Ren Su ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Pc12 Cells ◽  
Molecular Mechanisms ◽  
Glycogen Synthase ◽  
Neuroprotective Effect ◽  
Protective Action ◽  
Protective Effects ◽  
Phosphorylated Akt ◽  
Induced Apoptosis

The neurotoxicity of amyloid-β(Aβ) has been implicated as a critical cause of Alzheimer’s disease. Isorhynchophylline (IRN), an oxindole alkaloid isolated fromUncaria rhynchophylla,exerts neuroprotective effect againstAβ25–35-induced neurotoxicityin vitro. However, the exact mechanism for its neuroprotective effect is not well understood. The present study aimed to investigate the molecular mechanisms underlying the protective action of IRN againstAβ25–35-induced neurotoxicity in cultured rat pheochromocytoma (PC12) cells. Pretreatment with IRN significantly increased the cell viability, inhibited the release of lactate dehydrogenase and the extent of DNA fragmentation inAβ25–35-treated cells. IRN treatment was able to enhance the protein levels of phosphorylated Akt (p-Akt) and glycogen synthase kinase-3β(p-GSK-3β). Lithium chloride blockedAβ25–35-induced cellular apoptosis in a similar manner as IRN, suggesting that GSK-3βinhibition was involved in neuroprotective action of IRN. Pretreatment with LY294002 completely abolished the protective effects of IRN. Furthermore, IRN reversedAβ25–35-induced attenuation in the level of phosphorylated cyclic AMP response element binding protein (p-CREB) and the effect of IRN could be blocked by the PI3K inhibitor. These experimental findings unambiguously suggested that the protective effect of IRN againstAβ25–35-induced apoptosis in PC12 cells was associated with the enhancement of p-CREB expression via PI3K/Akt/GSK-3βsignaling pathway.

Involvement of caspase-8, -9, and -3 in high glucose-induced apoptosis in PC12 cells

2009 ◽  
Vol 459 (2) ◽  
pp. 47-51 ◽  
Author(s):  
Ali. M. Sharifi ◽  
Habib Eslami ◽  
Bagher Larijani ◽  
Jamshid Davoodi
Keyword(s):  
Pc12 Cells ◽  
High Glucose ◽  
Caspase 8 ◽  
Induced Apoptosis

scholarly journals Salvia macilenta exhibits antiglycating activity and protects PC12 cells against H2O2-induced apoptosis

2013 ◽  
Vol 66 (1) ◽  
pp. 169-179 ◽  
Author(s):  
Solaleh Khoramian Tusi ◽  
Fariba Khodagholi
Keyword(s):  
Pc12 Cells ◽  
Induced Apoptosis
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