scholarly journals G Protein‐Coupled Receptor Regulation of the alpha‐Arrestin ARRDC3

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Helen Wedegaertner ◽  
JoAnn Trejo
Keyword(s):  
G Protein ◽  
Receptor Regulation ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

Pleiotropic Role for GRKs and b-Arrestins in Receptor Regulation

Physiology ◽  
1997 ◽  
Vol 12 (4) ◽  
pp. 145-152 ◽  
Author(s):  
SSG Ferguson ◽  
J Zhang ◽  
LS Barak ◽  
MG Caron
Keyword(s):  
Angiotensin Ii ◽  
G Protein ◽  
Intracellular Trafficking ◽  
Coated Vesicle ◽  
Receptor Regulation ◽  
Receptor Desensitization ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
Trafficking Molecules ◽  
G Protein Coupled

G protein-coupled receptor kinases and arrestin proteins are well-characterized mediators of agonist-dependent G protein-coupled receptor desensitization. These proteins are now shown to play a dual role in receptor regulation by mediating both receptor uncoupling and sequestration, a process important for receptor resensitization. b-Arrestins bound to phosporylated b2-adrenergic and angiotensin II type 1A receptors act as intracellular trafficking molecules specifically targeting these receptors for dynamin-dependent clathrin-coated vesicle-mediated sequestration.

scholarly journals Evidence of an essential role of NHERF1 and NHEF2 in G‐protein coupled receptor regulation of CFTR‐mediated intestinal anion secretion in vivo

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Anurag Kumar Singh ◽  
Brigitte Riederer ◽  
Hugo R. Jonge ◽  
Mark Donowitz ◽  
Edward J. Weinman ◽  
...  
Keyword(s):  
G Protein ◽  
Essential Role ◽  
Receptor Regulation ◽  
G Protein Coupled Receptor ◽  
Anion Secretion ◽  
G Protein Coupled
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