scholarly journals A novel pharmacologic alternative to ganglionic blockade: cardiovascular responses to systemic terbutaline

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Elisha Peterson ◽  
John H Eisenach ◽  
Brad W Wilkins ◽  
Wayne T Nicholson ◽  
Christopher P Johnson ◽  
...  
Keyword(s):  
Cardiovascular Responses ◽  
Ganglionic Blockade

Cardiovascular and respiratory responses to slow ramp carotid sinus pressures in the dog

1990 ◽  
Vol 68 (4) ◽  
pp. 1465-1474 ◽  
Author(s):  
R. Jung ◽  
P. G. Katona
Keyword(s):  
Carotid Sinus ◽  
Rate Sensitivity ◽  
Cardiovascular Responses ◽  
Pressure Change ◽  
Arterial Pco2 ◽  
Ganglionic Blockade ◽  
Central Processing ◽  
Carotid Baroreceptor ◽  
Cardiovascular Variables

The respiratory and mean arterial pressure (MAP) responses to slow ramp pressure stimulation of carotid baroreceptors were compared in pentobarbital-anesthetized vagotomized dogs breathing 100% O2. Carotid sinus pressure (CSP) was raised from 50 (control) to 220 mmHg and then returned to control as linear ramps (+/- 1 mmHg/s) in isolated sinuses. MAP, heart rate (HR), ventilation (VE), frequency (f), and tidal volume (VT) were expressed as percent of control. The maximum difference between responses to positive and negative ramps at a given CSP (MAX) and the average difference (AVG) served as indicators of the hysteresis for each response. In 27 dogs MAP changed monotonically with varying CSP with insignificant (P = 0.27, MAX) or barely significant (P = 0.03, AVG) hysteresis, monotonic function being one that is continuously nondecreasing or continuously nonincreasing. Similar responses were obtained for HR. VE decreased as CSP increased, but the change was not monotonic. During negative ramp, VE increased back to control with an overshoot. Hysteresis for VE was pronounced (P less than 0.0001, both measures). The VE response was primarily determined by f; VT increased with CSP. To eliminate secondary respiratory effects due to alterations in MAP, in seven dogs similar experiments were performed after ganglionic blockade with hexamethonium. Hysteresis in VE and f persisted. To assess the role of changing arterial PCO2 (PaCO2) on VE, the CSP was held constant (after a ramp rise) at 140, 150, or 180 mmHg before reducing it at -1 mmHg/s to 50 mmHg; however, a significant hysteresis in VE was still observed. Further experiments, to eliminate secondary reflexes due to altered PaCO2, were performed in seven dogs after ganglionic blockade and paralysis with Flaxedil, with phrenic nerve activity as an indicator of (“neural”) respiration. The hysteresis in VE and f were no longer significant. In summary, the results indicate that 1) slow ramp carotid baroreceptor stimulation elicits both VE and cardiovascular responses, the VE response showing a dramatically higher hysteresis than the cardiovascular responses; 2) the ventilatory hysteresis is partially explained by the secondary changes in PaCO2 and perhaps by cardiovascular variables; and 3) the central processing of the baroventilatory reflex appears to be rate sensitive at a slower rate of pressure change than that which causes rate sensitivity in the baropressure reflex.

Reflex cardiovascular response to exercise is modulated by circulating vasopressin

1992 ◽  
Vol 263 (5) ◽  
pp. R1104-R1109 ◽  
Author(s):  
C. L. Stebbins
Keyword(s):  
Heart Rate ◽  
Receptor Antagonist ◽  
Cardiovascular Response ◽  
Regional Blood Flow ◽  
Plasma Concentrations ◽  
Cardiovascular Responses ◽  
Vascular Effect ◽  
Ganglionic Blockade ◽  
Hindlimb Muscles ◽  
Before And After

Peripheral vasopressin (AVP) can act centrally to sensitize the arterial baroreflex and/or peripherally to attenuate regional blood flow by a direct vascular effect. Because plasma concentrations of AVP increase during exercise, this study examined the possibility that AVP is capable of modulating the reflex cardiovascular response to static muscle contraction. Thus, in anesthetized cats, the pressor [mean arterial pressure (MAP)], myocardial contractile (dP/dt), and heart rate responses to 30-45 s of electrically induced static contraction of the hindlimb muscles were compared before and after intravenous injection of the V1 receptor antagonist d[CH2)5Tyr(Me)]-AVP (V1-x, n = 7), V1-x plus the V2 receptor antagonist [d(CH2)5,D-Phe2,Ile4,Arg8,Ala9]vasopressin (V2-x, n = 5), or the ganglionic blocker hexamethonium chloride (n = 5). In three additional cats, the contraction-induced cardiovascular response was monitored before and after injection of V1-x + V2-x and after hexamethonium. Subsequent to treatment with V1-x, the MAP and dP/dt responses to contraction were augmented by 18 +/- 5 and 22 +/- 10%, respectively (P < 0.05). After injection of V1-x + V2-x, the MAP and dP/dt responses were augmented to a similar extent (32 +/- 6 and 40 +/- 17%, respectively; P < 0.05). However, there was no difference in the magnitude of augmentation of these responses between the two conditions. The heart rate response was not altered by either treatment. Ganglionic blockade eliminated the cardiovascular responses to contraction. Last, when the pressor and contractile responses to contraction were initially augmented by administration of V1-x + V2-x, subsequent ganglionic blockade abolished the entire cardiovascular response.(ABSTRACT TRUNCATED AT 250 WORDS)

Effect of paraventricular nucleus lesions on cardiovascular responses elicited by stimulation of the subfornical organ in the rat

1985 ◽  
Vol 63 (7) ◽  
pp. 816-824 ◽  
Author(s):  
Michael B. Gutman ◽  
John Ciriello ◽  
Gordon J. Mogenson
Keyword(s):  
Electrical Stimulation ◽  
Arterial Pressure ◽  
Paraventricular Nucleus ◽  
Pressor Response ◽  
Cardiovascular Responses ◽  
Subfornical Organ ◽  
Short Latency ◽  
Peak Latency ◽  
Ganglionic Blockade ◽  
Stimulation Of

It has recently been reported that stimulation of the region of the subfornical organ (SFO) elicits an increase in arterial pressure. However, the mechanisms and forebrain neural circuitry that are involved in this cardiovascular response have not been elucidated. The present study was done in urethane-anaesthetized rats to determine whether selective activation of SFO neurons elicit cardiovascular responses and whether these responses were mediated by a pathway involving the paraventricular nucleus of the hypothalamus (PVH). Stimulation sites which required the lowest threshold current (30 μA) to elicit a pressor response and at which the largest rise in mean arterial pressure (MAP; 22 ± 2 mmHg) was elicited at a constant current intensity (150 μA) were histologically localized in the region of the SFO. Short (mean peak latency; 4 ± 2 s) and long (mean peak latency; 61 ± 8 s) latency increases in MAP were observed during and after electrical stimulation of the SFO, respectively. Cardiac slowing accompanied the short latency pressor response and cardioacceleration was observed in most (57%) of the cases to accompany the late pressor response. Microinjection of L-glutamate into the SFO consistently elicited cardiovascular responses qualitatively similar to those observed during electrical stimulation. Ganglionic blockade abolished the short latency increase in MAP and the accompanying bradycardia. However, the long latency pressor and cardioacceleratory responses were not altered by ganglionic blockade and adrenalectomy. Selective bilateral electrolytic or kainic acid lesions of the region of the PVH significantly attenuated the cardiovascular responses elicited by stimulation of the SFO. These data suggest that activation of neurons in the SFO elicit cardiovascular responses partially mediated by sympathetic outflow through a neural pathway involving the PVH.

John Ludbrook APPS Symposium Neural Mechanisms In The Cardiovascular Responses To Acute Central Hypovolaemia

2001 ◽  
Vol 28 (5-6) ◽  
pp. 479-487
Author(s):  
Roger G Evans ◽  
Sabatino Ventura ◽  
Roger Al Dampney ◽  
John Ludbrook
Keyword(s):  
Cardiovascular Responses ◽  
Neural Mechanisms ◽  
Central Hypovolaemia

In Search of Somatic Precursors of Spontaneous Insight

2018 ◽  
Vol 32 (3) ◽  
pp. 97-105 ◽  
Author(s):  
Wangbing Shen ◽  
Yuan Yuan ◽  
Chaoying Tang ◽  
Chunhua Shi ◽  
Chang Liu ◽  
...  
Keyword(s):  
Problem Solving ◽  
Direct Evidence ◽  
Electrodermal Activity ◽  
Cardiovascular Responses ◽  
Solution Time ◽  
Problem Solution ◽  
Insight Problem ◽  
Creative Insight ◽  
Insight Problem Solving ◽  
Analytic Problem

Abstract. A considerable number of behavioral and neuroscientific studies on insight problem solving have revealed behavioral and neural correlates of the dynamic insight process; however, somatic correlates, particularly somatic precursors of creative insight, remain undetermined. To characterize the somatic precursor of spontaneous insight, 22 healthy volunteers were recruited to solve the compound remote associate (CRA) task in which a problem can be solved by either an insight or an analytic strategy. The participants’ peripheral nervous activities, particularly electrodermal and cardiovascular responses, were continuously monitored and separately measured. The results revealed a greater skin conductance magnitude for insight trials than for non-insight trials in the 4-s time span prior to problem solutions and two marginally significant correlations between pre-solution heart rate variability (HRV) and the solution time of insight trials. Our findings provide the first direct evidence that spontaneous insight in problem solving is a somatically peculiar process that is distinct from the stepwise process of analytic problem solving and can be represented by a special somatic precursor, which is a stronger pre-solution electrodermal activity and a correlation between problem solution time and certain HRV indicators such as the root mean square successive difference (RMSSD).

The role of compassionate love in shaping psychological, behavioral, and cardiovascular responses to a partner in distress

2014 ◽  
Author(s):  
Molly Ann Metz ◽  
Heidi Kane ◽  
Thery Prok ◽  
Christena Cleveland ◽  
Nancy Collins
Keyword(s):  
Cardiovascular Responses ◽  
Compassionate Love

Anger and threat cardiovascular responses to interactions with a prejudiced other

2007 ◽  
Author(s):  
Sarah S. M. Townsend ◽  
Pamela J. Sawyer ◽  
Bettina J. Casad ◽  
Brenda Major ◽  
Wendy Berry Mendes
Keyword(s):  
Cardiovascular Responses

Fast Foes: The affective consequences of interacting in a negative self-disclosure situation.

2020 ◽  
Author(s):  
Jonathan Gordils ◽  
Jeremy Jamieson
Keyword(s):  
Social Interactions ◽  
Social Life ◽  
Large Body ◽  
Cardiovascular Responses ◽  
Social Contexts ◽  
Subjective Experiences ◽  
Self Disclosure ◽  
Negative Behaviors ◽  
Nuanced Understanding ◽  
Affective Consequences

Background and Objectives: Social interactions involving personal disclosures are ubiquitous in social life and have important relational implications. A large body of research has documented positive outcomes from fruitful social interactions with amicable individuals, but less is known about how self-disclosing interactions with inimical interaction partners impacts individuals. Design and Methods: Participants engaged in an immersive social interaction task with a confederate (thought to be another participant) trained to behave amicably (Fast Friends) or inimically (Fast Foes). Cardiovascular responses were measured during the interaction and behavioral displays coded. Participants also reported on their subjective experiences of the interaction. Results: Participants assigned to interact in the Fast Foes condition reported more negative affect and threat appraisals, displayed more negative behaviors (i.e., agitation and anxiety), and exhibited physiological threat responses (and lower cardiac output in particular) compared to participants assigned to the Fast Friends condition. Conclusions: The novel paradigm demonstrates differential stress and affective outcomes between positive and negative self-disclosure situations across multiple channels, providing a more nuanced understanding of the processes associated with disclosing information about the self in social contexts.

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