scholarly journals Effects of aging, hypertension, and diabetes on low‐frequency arterial pressure oscillations

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Antti M Kiviniemi ◽  
Mikko P Tulppo ◽  
Tapio Seppänen ◽  
Katelyn Norton ◽  
Maria F Frances ◽  
...  
Keyword(s):  
Arterial Pressure ◽  
Low Frequency ◽  
Pressure Oscillations ◽  
Effects Of Aging

scholarly journals Low-frequency arterial pressure fluctuations do not reflect sympathetic outflow: gender and age differences

1998 ◽  
Vol 274 (4) ◽  
pp. H1194-H1201 ◽  
Author(s):  
J. Andrew Taylor ◽  
Todd D. Williams ◽  
Douglas R. Seals ◽  
Kevin P. Davy
Keyword(s):  
Arterial Pressure ◽  
Low Frequency ◽  
Total Activity ◽  
Sympathetic Outflow ◽  
Pressure Oscillations ◽  
Young Males ◽  
Young Females ◽  
Sympathetic Nervous ◽  
Mayer Wave ◽  
Older Males

Low-frequency arterial pressure oscillations (Mayer waves) have been proposed as an index of vascular sympathetic outflow. However, cross-sectional differences in these pressure oscillations may not reflect different levels of sympathetic nervous outflow in humans. Three groups of healthy subjects with characteristically different sympathetic nervous outflow were studied: young females ( n = 10, 18–28 yr), young males ( n = 11, 18–29 yr), and older males ( n = 13, 60–72 yr). Average R-R interval, arterial pressures, and systolic pressure variability at the Mayer wave frequency (0.05–0.15 Hz) did not differ among the three groups. Diastolic pressure Mayer wave variability was similar in young females vs. young males (39 ± 10 vs. 34 ± 5 mmHg2) and lower in older males vs. young males (14 ± 2 mmHg2; P < 0.05). In contrast, muscle sympathetic activity was lowest in young females (892 ± 249 total activity/min) and highest in older males (3,616 ± 528 total activity/min; both P < 0.05 vs. young males: 2,505 ± 285 total activity/min). Across the three groups, arterial pressure Mayer wave variability did not correlate with any index of sympathetic activity. Our results demonstrate that arterial pressure Mayer wave amplitude is not a surrogate measure of vascular sympathetic outflow.

Effect of area postrema lesion on low-frequency arterial pressure oscillations in dogs

1987 ◽  
Vol 253 (3) ◽  
pp. H524-H530 ◽  
Author(s):  
F. E. Pollick ◽  
K. L. Barnes ◽  
C. M. Ferrario
Keyword(s):  
Arterial Pressure ◽  
Area Postrema ◽  
Control Period ◽  
Power Spectra ◽  
Low Frequency ◽  
Experimental Period ◽  
Low Frequency Oscillation ◽  
Pressure Oscillations ◽  
Before And After ◽  
Group A

To explore the possibility that chronic inactivation of the area postrema (AP) may alter the frequency distribution of oscillations in blood pressure, the power spectra for mean arterial pressure (MAP) were evaluated in conscious dogs before and after heat coagulation (n = 4) or sham lesions (n = 6) of the AP. No significant changes in MAP were observed in either group of dogs after surgery. Tachycardia was seen in AP-lesioned animals after surgery; no consistent changes in heart rate were found in sham-lesioned dogs. Spectra were averaged to provide a group spectral estimate for the AP-lesioned and sham-lesioned groups, respectively, for each experimental period. In the sham-lesioned group a variance peak was observed at approximately 0.03 Hz both before and after surgery. The same peak was seen in the AP-lesioned group during the control period but disappeared following AP lesion, apparently because a greater proportion of the variance was shifted toward frequencies below 0.03 Hz. In addition, a peak related to respiratory rate was present in both groups before surgery but was selectively abolished by AP lesion. AP lesion also substantially reduced the power associated with frequencies between 0.1 and 0.4 Hz. The use of spectral analysis has allowed us to demonstrate that a low-frequency oscillation of MAP in conscious, resting dogs requires the integrity of the AP and that the 0.1- to 0.4-Hz components of the variability of MAP are attenuated after removal of the AP.(ABSTRACT TRUNCATED AT 250 WORDS)

Cerebral circulation during mild +Gz hypergravity by short-arm human centrifuge

2012 ◽  
Vol 112 (2) ◽  
pp. 266-271 ◽  
Author(s):  
Ken-ichi Iwasaki ◽  
Yojiro Ogawa ◽  
Ken Aoki ◽  
Ryo Yanagida
Keyword(s):  
Steady State ◽  
Transfer Function ◽  
Arterial Pressure ◽  
High Frequency ◽  
Cerebral Circulation ◽  
Cerebral Autoregulation ◽  
Low Frequency ◽  
Frequency Range ◽  
Pressure Oscillations ◽  
Dynamic Cerebral Autoregulation

We examined changes in cerebral circulation in 15 healthy men during exposure to mild +Gz hypergravity (1.5 Gz, head-to-foot) using a short-arm centrifuge. Continuous arterial pressure waveform (tonometry), cerebral blood flow (CBF) velocity in the middle cerebral artery (transcranial Doppler ultrasonography), and partial pressure of end-tidal carbon dioxide (ETco2) were measured in the sitting position (1 Gz) and during 21 min of exposure to mild hypergravity (1.5 Gz). Dynamic cerebral autoregulation was assessed by spectral and transfer function analysis between beat-to-beat mean arterial pressure (MAP) and mean CBF velocity (MCBFV). Steady-state MAP did not change, but MCBFV was significantly reduced with 1.5 Gz (−7%). ETco2 was also reduced (−12%). Variability of MAP increased significantly with 1.5 Gz in low (53%)- and high-frequency ranges (88%), but variability of MCBFV did not change in these frequency ranges, resulting in significant decreases in transfer function gain between MAP and MCBFV (gain in low-frequency range, −17%; gain in high-frequency range, −13%). In contrast, all of these indexes in the very low-frequency range were unchanged. Transfer from arterial pressure oscillations to CBF fluctuations was thus suppressed in low- and high-frequency ranges. These results suggest that steady-state global CBF was reduced, but dynamic cerebral autoregulation in low- and high-frequency ranges was improved with stabilization of CBF fluctuations despite increases in arterial pressure oscillations during mild +Gz hypergravity. We speculate that this improvement in dynamic cerebral autoregulation within these frequency ranges may have been due to compensatory effects against the reduction in steady-state global CBF.

Dynamic Stability of a Water Brake Dynamometer

1998 ◽  
Vol 120 (1) ◽  
pp. 89-96 ◽  
Author(s):  
R. A. Van den Braembussche ◽  
H. Malys
Keyword(s):  
High Frequency ◽  
Low Frequency ◽  
Lumped Parameter Model ◽  
Stable Operation ◽  
Pressure Oscillations ◽  
Lumped Parameter ◽  
Flow Oscillations ◽  
Brake Dynamometer ◽  
Low Torque ◽  
Frequency Variations

A lumped parameter model to predict the high frequency pressure oscillations observed in a water brake dynamometer is presented. It explains how the measured low frequency variations of the torque are a consequence of the variation in amplitude of the high frequency flow oscillations. Based on this model, geometrical modifications were defined, aiming to suppress the oscillations while maintaining mechanical integrity of the device. An experimental verification demonstrated the validity of the model and showed a very stable operation of the modified dynamometer even at very low torque.

The vertical vestibulo-ocular reflex, and its interaction with vision during active head motion: Effects of aging

2001 ◽  
Vol 11 (1) ◽  
pp. 3-12
Author(s):  
Ji Soo Kim ◽  
James A. Sharpe
Keyword(s):  
Smooth Pursuit ◽  
Low Frequency ◽  
The Elderly ◽  
Head Motion ◽  
Head Tracking ◽  
Elderly Age ◽  
Ocular Reflex ◽  
Visual Enhancement ◽  
Vestibulo Ocular Reflex ◽  
Effects Of Aging

The effects of aging on the vertical vestibulo-ocular reflex (VOR), and its interactions with vision during active head motion had not been investigated. We measured smooth pursuit, combined eye-head tracking, the VOR, and its visual enhancement and cancellation during active head motion in pitch using a magnetic search coil technique in 21 younger (age < 65) and 10 elderly (age ⩾ 65) subjects. With the head immobile, subjects pursued a target moving sinusoidally with a frequency range of 0.125 to 2.0 Hz, and with peak target accelerations (PTAs) ranging from 12 to 789Âř/s 2 . Combined eye-head tracking, the VOR in darkness, and its visual enhancement during fixation of an earth-fixed target (VVOR) were measured during active sinusoidal head motion with a peak-to-peak amplitude of 20Âř at frequencies of 0.25, 0.5, 1.0 and 2.0 Hz. The efficacy of VOR cancellation was determined from VOR gains during combined eye-head tracking. VOR and VVOR gains were symmetrical in both directions and did not change with aging, except for reduced gains of the downward VOR and VVOR at low frequency (0.25 Hz). However, in the elderly, smooth pursuit, and combined eye-head tracking gains and the efficacy of cancellation of the VOR were significantly lower than in younger subjects. In both the young and elderly groups, VOR gain in darkness did not vary with the frequency of active head motion while the gains of smooth pursuit, combined eye-head tracking, and VVOR declined with increasing target frequency. VOR and VVOR performance in the elderly implicates relative preservation of neural structures subserving vertical vestibular smooth eye motion in senescence.

scholarly journals Physiological Sympathetic Activation Reduces Systemic Inflammation: Role of Baroreflex and Chemoreflex

2021 ◽  
Vol 12 ◽  
Author(s):  
Fernanda Brognara ◽  
Jaci Airton Castania ◽  
Alexandre Kanashiro ◽  
Daniel Penteado Martins Dias ◽  
Helio Cesar Salgado
Keyword(s):  
Nervous System ◽  
Arterial Pressure ◽  
Systemic Inflammation ◽  
Inflammatory Responses ◽  
Low Frequency ◽  
Systolic Arterial Pressure ◽  
Sympathetic Activation ◽  
Bilateral Carotid Occlusion ◽  
Bilateral Carotid ◽  
Reflex Activation

Baroreflex and chemoreflex act through the autonomic nervous system, which is involved with the neural regulation of inflammation. The present study reports the effects of reflex physiological sympathetic activation in endotoxemic rats using bilateral carotid occlusion (BCO), a physiological approach involving the baroreflex and chemoreflex mechanisms and the influence of the baroreceptors and peripheral chemoreceptors in the cardiovascular and systemic inflammatory responses. After lipopolysaccharide (LPS) administration, the arterial pressure was recorded during 360 min in unanesthetized rats, and serial blood samples were collected to analyze the plasma cytokine levels. BCO elicited the reflex activation of the sympathetic nervous system, providing the following outcomes: (I) increased the power of the low-frequency band in the spectrum of the systolic arterial pressure during the BCO period; (II) reduced the levels of pro-inflammatory cytokines in plasma, including the tumor necrosis factor (TNF) and the interleukin (IL)-1β; (III) increased the plasma levels of anti-inflammatory cytokine IL-10, 90 min after LPS administration. Moreover, selective baroreceptor or chemoreceptor denervation deactivated mechanosensitive and chemical sensors, respectively, and decreased the release of the LPS-induced cytokine but did not alter the BCO modulatory effects. These results show, for the first time, that physiological reflex activation of the sympathetic circuit decreases the inflammatory response in endotoxemic rats and suggest a novel function for the baroreceptors as immunosensors during the systemic inflammation.

scholarly journals Arterial-cardiac baroreflex function: insights from repeated squat-stand maneuvers

2009 ◽  
Vol 297 (1) ◽  
pp. R116-R123 ◽  
Author(s):  
Rong Zhang ◽  
Jurgen A. H. R. Claassen ◽  
Shigeki Shibata ◽  
Sinem Kilic ◽  
Kristin Martin-Cook ◽  
...  
Keyword(s):  
Transfer Function ◽  
Arterial Pressure ◽  
Body Position ◽  
The Elderly ◽  
Elderly Subjects ◽  
Pulley System ◽  
New Approach ◽  
Baroreflex Function ◽  
Effects Of Aging ◽  
Transfer Function Gain

To assess baroreflex function under closed-loop conditions, a new approach was used to generate large and physiological perturbations in arterial pressure. Blood pressure (BP) and R-R interval were recorded continuously in 20 healthy young (33 ± 8 yr) and eight elderly subjects (66 ± 6 yr). Repeated squat-stand maneuvers at the frequencies of 0.05 and 0.1 Hz were performed to produce periodic oscillations in BP to provoke the baroreflex. To assess the effects of the muscle reflex and/or central command on the baroreflex, passive squat-stand maneuvers were conducted using a pulley system to assist changes in body position. Transfer function between changes in BP and R-R interval was estimated to assess the arterial-cardiac baroreflex. Relative to resting conditions, large and coherent oscillations in BP and R-R interval were produced during both active and passive squat-stand maneuvers. However, changes in BP were smaller during passive than during active maneuvers. Changes in R-R interval were reduced commensurately. Therefore, transfer function gain did not change between the two maneuvers. Compared with the young, transfer function gain was reduced and the phase became more negative in the elderly, demonstrating the well-known effects of aging on reducing baroreflex sensitivity. Collectively, these findings suggest that the changes in R-R interval elicited by BP perturbations during squat-stand maneuvers are mediated primarily by a baroreflex mechanism. Furthermore, baroreflex function can be assessed using the transfer function method during large perturbations in arterial pressure.

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