scholarly journals Anti‐inflammatory effects of hypoxia‐preconditioned human periodontal ligament cell secretome in an experimental model of multiple sclerosis: a key role of IL‐37

2017 ◽  
Vol 31 (12) ◽  
pp. 5592-5608 ◽  
Author(s):  
Sabrina Giacoppo ◽  
Soundara Rajan Thangavelu ◽  
Francesca Diomede ◽  
Placido Bramanti ◽  
Pio Conti ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Experimental Model ◽  
Periodontal Ligament ◽  
Periodontal Ligament Cell ◽  
Anti Inflammatory

Role of Ascorbic Acid in Periodontal Ligament Cell Differentiation

2004 ◽  
Vol 75 (5) ◽  
pp. 709-716 ◽  
Author(s):  
Satoshi Ishikawa ◽  
Kengo Iwasaki ◽  
Motohiro Komaki ◽  
Isao Ishikawa
Keyword(s):  
Ascorbic Acid ◽  
Cell Differentiation ◽  
Periodontal Ligament ◽  
Periodontal Ligament Cell

Potent T cell mediated anti‐inflammatory role of the selective CB2 agonist lenabasum in multiple sclerosis

2021 ◽  
Author(s):  
Marta Tiberi ◽  
Tama Evron ◽  
Stefano Saracini ◽  
Laura Boffa ◽  
Nicola Biagio Mercuri ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
Anti Inflammatory ◽  
Cb2 Agonist

Role of HSP70 protein in human periodontal ligament cell function and physiology

2019 ◽  
Vol 221 ◽  
pp. 76-83 ◽  
Author(s):  
Michael Wolf ◽  
Jana Marciniak ◽  
Stefan Lossdörfer ◽  
Christian Kirschneck ◽  
Isabel Brauner ◽  
...  
Keyword(s):  
Periodontal Ligament ◽  
Cell Function ◽  
Periodontal Ligament Cell ◽  
Hsp70 Protein

The influence of sex hormones on cytokines in multiple sclerosis and experimental autoimmune encephalomyelitis: a review

2005 ◽  
Vol 11 (3) ◽  
pp. 349-359 ◽  
Author(s):  
Hans HLP van den Broek ◽  
Jan GMC Damoiseaux ◽  
Marc H De Baets ◽  
Raymond MM Hupperts
Keyword(s):  
Multiple Sclerosis ◽  
Immune Response ◽  
T Cells ◽  
Regulatory T Cells ◽  
Sex Hormones ◽  
Inflammatory Cytokines ◽  
Cytokine Production ◽  
Anti Inflammatory ◽  
Experimental Autoimmune

The female predominance of multiple sclerosis (MS) has suggested that hormonal differences between the sexes must confer some protective effect on males or enhance the susceptibility of females to this disease. There has been evidence that gonadal hormones can modulate the immune response regulated by antigen presenting cells and T cells. These cells control the immune response by the production of interacting pro- and anti-inflammatory cytokines. The first include the acute phase pro-inflammatory cytokines of the innate immune response as well as the T-helper 1 (Th1) cytokines, while the later contain the Th2 cytokines as well as the suppressor cytokines. There is some evidence that MS and experimental autoimmune encephalitis (EAE) are Th1 cell-mediated diseases. For this reason many studies have been done to influence the pro-inflammatory cytokine production of these Th1 cells in favour of an anti-inflammatory immune response as mediated by Th2 cells. However the role of the regulatory T cells in this context is not clearly understood. Here we review the studies concerning the role of sex hormones on the cytokine production in relation to the disease course of MS and EAE and in particular in the light of the recent revival of the regulatory T cells and their suppressive cytokines.

scholarly journals Nanomodulation of Macrophages in Multiple Sclerosis

Cells ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 543 ◽  
Author(s):  
Frances K. Nally ◽  
Chiara De Santi ◽  
Claire E. McCoy
Keyword(s):  
Multiple Sclerosis ◽  
Immune Cells ◽  
Early Stage ◽  
Therapeutic Benefit ◽  
Macrophage Polarisation ◽  
Tissue Repair And Regeneration ◽  
Inflammatory State ◽  
Anti Inflammatory ◽  
Novel Strategy

Multiple Sclerosis (MS) is a chronic demyelinating autoimmune disease primarily affecting young adults. Despite an unclear causal factor, symptoms and pathology arise from the infiltration of peripheral immune cells across the blood brain barrier. Accounting for the largest fraction of this infiltrate, macrophages are functionally heterogeneous innate immune cells capable of adopting either a pro or an anti-inflammatory phenotype, a phenomenon dependent upon cytokine milieu in the CNS. This functional plasticity is of key relevance in MS, where the pro-inflammatory state dominates the early stage, instructing demyelination and axonal loss while the later anti-inflammatory state holds a key role in promoting tissue repair and regeneration in later remission. This review highlights a potential therapeutic benefit of modulating macrophage polarisation to harness the anti-inflammatory and reparative state in MS. Here, we outline the role of macrophages in MS and look at the role of current FDA approved therapeutics in macrophage polarisation. Moreover, we explore the potential of particulate carriers as a novel strategy to manipulate polarisation states in macrophages, whilst examining how optimising macrophage uptake via nanoparticle size and functionalisation could offer a novel therapeutic approach for MS.

scholarly journals Protective Role of (RS)-glucoraphanin Bioactivated with Myrosinase in an Experimental Model of Multiple Sclerosis

2013 ◽  
Vol 19 (8) ◽  
pp. 577-584 ◽  
Author(s):  
Sabrina Giacoppo ◽  
Maria Galuppo ◽  
Renato Iori ◽  
Gina R. De Nicola ◽  
Giovanni Cassata ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Experimental Model ◽  
Protective Role

Psychological symptoms and perceived cognitive impairment in multiple sclerosis: The role of rumination.

2018 ◽  
Vol 63 (2) ◽  
pp. 286-294 ◽  
Author(s):  
Bailee L. Malivoire ◽  
Crystal J. Hare ◽  
Tae L. Hart
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Psychological Symptoms
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