Liver Function Tests in Sickle Cell Anemia Patients: A Case-Control Study in Saudi Arabia

1987 ◽  
Vol 293 (6) ◽  
pp. 371-376 ◽  
Author(s):  
M.A.F. El-Hazmi ◽  
A.R. Al-Swailem ◽  
A.S. Warsy
Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 1644-1644
Author(s):  
Marina Roizenblatt ◽  
Frederico Pollack-Filho ◽  
Joao R Sato ◽  
Perla Vicari ◽  
Francisca Veloso ◽  
...  

Abstract Abstract 1644 Background. Priapism has been described as a sickle cell anemia (SCA) manifestation that occurs frequently during sleep. Given that hypoxemia has been implicated in the pathogenesis of SCA complications, we conducted this case control study of overnight polysomnography and penile tumescence recording in SCA adults with and without priapism, with the hypothesis that SCA patients with priapism might exhibit apnea and oxyhemoglobin desaturation during sleep. Objectives. The primary endpoint was to determine the relation between increase in penile tumescence (of 20%) and respiratory sleep events (apnea, hypopnea and desaturation >3%). Further sleep event associations with penile tumescence variation and other differences between groups regarding sleep pattern were assessed as secondary endpoints. Methods. Seventeen SCA adults with priapism and 14 without history during the previous 12 month period were submitted to clinical interview and overnight polysomnography (Somnologica, Embla™), concomitantly performed with penile tumescence recording (Rigiscan Plus, Timm Medical™). Results and Discussion. There was no statistical difference between groups (t test, Chi2 or Fisher) in terms of age (mean ± s.d., 31.2 ± 14.0 vs. 27.8 ± 7.0 yrs, p=0.39), body mass index (20.9 ± 3.7 vs. 21.4 ± 2.3 kg/m2, p=0.66), use of hydroxyurea (41 vs. 43%, p=1.00), levels of ferritin (257.2 ± 291.8 vs. 429.1 ± 410.8 mg/L, p=0.27), hemoglobin (10.0 ± 1.9 vs. 9.4 ± 1.7 mg/dL, p=0.45) and hematocrit (27.4 ± 8.3 vs. 27.0 ± 5.3 %, p=0.89). No difference was also observed in sleep architecture and number of events of increase in penile tumescence, both in non rapid eye movement (non REM) and REM sleep (21.9 ± 6.8 vs. 18.2 ± 7.6, p=0.17 and 7.5 ± 3.3 vs. 8.3 ± 5.0, p=0.59, respectively). Coincidence of these events with apnea-hypopnea, desaturation and periodic leg movement (PLM) events in non REM sleep was greater in SCA patients with priapism than in those without it (16.9 ± 11.1 vs. 7.9 ± 7.1, respectively, p=0.01). PLM index was increased in both groups, particularly in SCA patients with priapism (16.1 ± 16.2 vs. 5.7 ± 5.4 /h, p= 0.03) and associated with restless leg syndrome (88.2 vs. 50.0 %, respectively, p=0.02). Desaturation index was also higher in priapism group, in comparison to non-priapism (12.7 ± 8.8 vs. 7.6 ± 3.6 /h, respectively, p=0.05), as well as apnea hypopnea index (12.2 ± 11.0 vs. 5.5 ± 4.5 /h, respectively, p=0.04). Conclusion. Compared to the group without priapism, SCA patients with priapism presented increase in apnea hypopnea index, PLM indexes during sleep and also association of increase in penile tumescence with respiratory events and PLM during non REM sleep. Our findings reinforce the literature data which highlights the link between disordered sleep and vaso-occlusive events in SCA. Moreover, the high frequency of PLM in SCA patients could be related to lower hepcidin levels recently observed in both SCA and restless legs syndrome. FAPESP CEPID 98/14303-3 and AFIP. Disclosures: No relevant conflicts of interest to declare.


2019 ◽  
Author(s):  
Ritha Mbono Betoko ◽  
Suzanne Sap Ngo Um ◽  
Anastasie Yanda Alima ◽  
David Chelo ◽  
Jocelyn Tony Nengom ◽  
...  

Abstract Background Puberty is reported to be impaired in children with Sickle Cell Anemia (SCA). We therefore, aimed to explore clinical and hormonal features of puberty in Cameroonian children with emphasis on the factors associated with delayed puberty during SCA.Methods During a case-control study, we included 64 children aged 8 to 18 years with SCA matched to healthy controls. We assessed height, weight, body mass index, body composition and Tanner stages. Hormonal measurements included Follicle Stimulating Hormone, Luteinizing Hormone and sex steroids (estrogens/ testosterone) with radio-immunologic assays. We used a non-parametric test (Mann U Whitney Wilcoxon) to compare the median values ​​between cases and controls. We looked into associations between severity criteria of SCA and delayed puberty through multivariate analysis.Results Delayed puberty was reported in 27.3% of girls and 10% of boys with SCA. Median age of menarche was delayed by 2 years compared to controls. SCA patients had low free fat mass compared to controls (p = 0.03). Abnormal levels of Antimullerian hormone were reported in cases. History of severe infection, acute chest syndrome as well as low hemoglobin level were associated with delayed sexual maturation in children with SCA.Conclusion Our study reveals delayed puberty in children with SCA. Moreover, puberty is affected by severity of the disease. This highlights importance of regular monitoring of puberty during follow-up of these children.


2007 ◽  
Vol 122 (4) ◽  
pp. 331-335 ◽  
Author(s):  
A Daudia ◽  
N S Jones

AbstractSurgery remains the treatment of choice for mycetoma of the paranasal sinuses. Itraconazole has a useful role in reducing both the amount of surgery required and the amount of peri-operative bleeding in allergic aspergillosis, and continuing its use post-operatively for six weeks appears to reduce the recurrence rate (although a case–control study is required to validate this observation). In chronic invasive aspergillosis, itraconazole alone appears to be curative, although liver function tests should be monitored and other interactions considered. Imaging is required to monitor resolution; remineralisation occurs after approximately six months. In fulminant aspergillosis, radical surgery and amphotericin B continue to be the treatments of choice. This review discusses the management of aspergillosis of the paranasal sinuses, and in particular the role of itraconazole antifungal therapy.


2017 ◽  
Vol 32 (1) ◽  
pp. e22160
Author(s):  
Joseph K. Sungu ◽  
Olivier Mukuku ◽  
Augustin Mulangu Mutombo ◽  
Paul Mawaw ◽  
Michel N. Aloni ◽  
...  

2017 ◽  
Vol 12 (1) ◽  
Author(s):  
Mohammad Reza Bordbar ◽  
Sezaneh Haghpanah ◽  
Tahereh Zarei ◽  
Mohammad Hossein Dabbaghmanesh ◽  
Gholamhossein Ranjbar Omrani ◽  
...  

2017 ◽  
Vol 20 (11) ◽  
pp. 1428
Author(s):  
SA Akuyam ◽  
A Abubakar ◽  
N Lawal ◽  
R Yusuf ◽  
SM Aminu ◽  
...  

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