Combined Therapy of Insulin and Tolazamide Decreases Insulin Requirement and Serum Triglycerides in Obese Patients with Noninsulin-Dependent Diabetes Mellitus

Abstract Background: There is abundant evidence reporting the relationship between triglycerides levels and type 2 diabetes mellitus, however few studies confirmed the influence of triglycerides levels on the incidence of diabetes. Bariatric surgery may lead to the remission of type 2 diabetes mellitus, but the effect of basal serum triglycerides levels on this reversal is unknown. This study aimed to assess the association between preoperative triglycerides levels and pre- and type 2 diabetes mellitus remission in obese patients one year after bariatric surgery. Methods: A retrospective study was conducted among 1959 obese patients who underwent bariatric surgery in our entre. Data on socio-demographic and clinical characteristics were used. Pre-diabetes and type 2 diabetes mellitus remission was defined as normal glycaemic measures at least one year’s duration without pharmacological therapy. Logistic regression models, crude and adjusted for sex, age, preoperative serum triglycerides levels and type of bariatric surgery, were used. Results: The median of preoperative serum triglycerides level was 121.00 (SD=75.00) mg/dL, and 34.7% and 30.0% of patients presented pre- and type 2 diabetes mellitus, respectively, at baseline. Preoperative serum triglycerides levels were higher in type 2 diabetes mellitus patients (139.00 vs. 106.00 mg/dL, in normal glycaemic patients; p<0.001) and showed to be significantly correlated with fasting glycaemia, glycated haemoglobin, homeostasis model assessment of insulin resistance and homeostasis model assessment of β-cell function. One year after bariatric surgery, 62.5% of patients with pre- or type 2 diabetes at baseline showed remission. Preoperative serum triglycerides levels were negatively associated with this remission (OR: 0.997; 95%CI=0.995–0.998), independently of, sex, age and type of bariatric surgery. Conclusions: One year after bariatric surgery, 62.5% of patients showed pre- or type 2 diabetes mellitus remission, being the preoperative serum triglycerides levels an important clinical parameter for remission. Keywords: triglycerides, diabetes, remission, obesity, bariatric surgery

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Epidemiology of diabetes mellitus in relation to other cardiovascular risk factors in Lebanon

Eastern Mediterranean Health Journal ◽

10.26719/1997.3.3.462 ◽

1997 ◽

Vol 3 (3) ◽

pp. 462-471

Author(s):

Ibrahim S. Salti ◽

Mustafa Khogali ◽

Samir Alam ◽

Najib Abu Haidar ◽

Amal Masri

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Glucose Tolerance ◽

Impaired Glucose Tolerance ◽

Insulin Dependent Diabetes Mellitus ◽

Insulin Dependent Diabetes ◽

Dependent Diabetes Mellitus ◽

Main Risk Factor ◽

Serum Triglycerides ◽

Insulin Dependent

A study of 2518 Lebanese subjects [1138 males, 1380 females] aged 30 years and over revealed an overall prevalence of non-insulin-dependent diabetes mellitus and impaired glucose tolerance of 13.1% and 6.0% respectively. The prevalence of non-insulin-dependent diabetes mellitus was similar in both sexes, while impaired glucose tolerance was slightly higher among females;both increased steadily with age. The main risk factor was obesity [55% in males, 67% in females]. Participants with diabetes and impaired glucose tolerance were more likely to have heart disease, and had slightly higher blood pressure and serum triglycerides

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Indirect calorimetry in the differential diagnosis of the metabolic status of obese patients with non-insulin dependent diabetes mellitus

Problems of Endocrinology ◽

10.14341/probl11937 ◽

1993 ◽

Vol 39 (2) ◽

pp. 4-7

Author(s):

A. V. Dreval ◽

V. G. Vysotsky ◽

T. A. Yatsyshina ◽

O. A. Plotnikova ◽

D. P. Tishin ◽

...

Keyword(s):

Diabetes Mellitus ◽

Indirect Calorimetry ◽

Insulin Dependent Diabetes Mellitus ◽

Insulin Dependent Diabetes ◽

Favorable Effect ◽

Dependent Diabetes Mellitus ◽

Obese Patients ◽

Oxidation Rates ◽

Insulin Dependent ◽

Soybean Diet

Twenty-one obese patients with non-insulin dependent diabetes mellitus, 16 female and 5 male ones, were led similar isocaloric rations, differing only by the share of substitution of the traditional protein products (0 %, 60 %, 30 %, 45 %) in the Danpro-S, Danpro-Fibre soybean protein concentrate. The parameters tested were daily glycemia, C-peptides, blood hydrocortisone, and urinary excretion of nitrous metabolites. Indirect calorimetry was used to assess the protein, fat, and carbohydrate oxidation rates at rest. Addition of proteins of a plant origin to the diets of such patients was associated with significant changes of the energy metabolism at rest at the expense of increased oxidation of carbohydrates and reduced protein catabolism, that may be regarded as a favorable effect. In this patient population a 30 % soybean diet brings about an almost maximal positive effect in patients with the first degree of obesity, whereas in those with the second degree of obesity such effect is attained by the 45 % soybean diet.

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