Modelling of rocuronium and pancuronium in the anterograde perfused peroneal nerve anterior tibialis muscle model of the ‘myasthenic rat’ vs. control

2001 ◽  
Vol 18 (Supplement 23) ◽  
pp. 95-96
Author(s):  
A. De Haes ◽  
M. C. Houwertjes ◽  
M. H. De Baets ◽  
J. B. Kuks ◽  
J. H. Proost ◽  
...  
2016 ◽  
Vol 30 (4) ◽  
pp. 552-556
Author(s):  
Guru Dutta Satyarthee ◽  
Luis Rafael Moscote-Salazar ◽  
Anil Kothiwala ◽  
A.K. Mahapatra

Abstract Wasting of muscle is usually a feature of lower motor neuron pathology, astonishingly parasagittal intracranial lesion affecting parietal lobe of cerebral hemisphere may be associated with Wasting of contralateral calf muscle. It can be associated with spastic foot drop. Foot drop is a common neurological state presenting with weakness involving anterior tibialis muscle causing inability of foot extension. Foot drop is commonly caused lower motor neuron disease pathology and a common cause includes L4-L5 radiculopathy or peroneal peripheral neuropathy. However, extremely rarely can be caused by intracranial pathology e.g. falcine meningioma and represents an important localization sign. Authors report an interesting case of calf muscle wasting caused by falcine meningioma, which may escape detection to remind rare but extremely important neurological localizing sign and ask for through and further neurological evaluation prior to concluding a final neurological diagnosis.


1993 ◽  
Vol 91 (1) ◽  
pp. 154-157 ◽  
Author(s):  
Luca Siliprandi ◽  
Ginetta Martini ◽  
Angelo Chiarelli ◽  
Franco Mazzoleni

2019 ◽  
Vol 17 (6) ◽  
pp. 423-429 ◽  
Author(s):  
Álisson de Carvalho Gonçalves ◽  
Einy Jéssika Siqueira Moreira ◽  
Guilherme Vannucchi Portari

1996 ◽  
Vol 17 (10) ◽  
pp. 615-619 ◽  
Author(s):  
John R. Prahinski ◽  
Kathleen A. McHale ◽  
H. Thomas Temple ◽  
Joseph P. Jackson

In the Riordan (bridle) transfer, the posterior tibialis muscle as motor is routed through the interosseous membrane and anastomosed into a “bridle” formed by the distal tibialis anterior and peroneus longus muscles. In theory, the bridle provides inversion/eversion balance even if the transfer effects only tenodesis. However, the procedure has been criticized because its insertion is not into bone. This review analyzes the use of bridle transfer in flaccid paresis involving musculature innervated by the peroneal nerve. Surgery was performed 1 to 3 years after injury for patients with traumatic etiology. Ten patients are reviewed at 61 months’ mean follow-up. Eight patients had traumatic peroneal nerve loss. Two had neuromuscular etiology. Evaluation included review of records, telephone interviews, and physical examinations. Data on functional status included walking barefoot, running, need for bracing, return to duty, and patient satisfaction. Physical examination recorded ankle position and motions, gait findings, and results of static electromyograms. All patients were able to walk barefoot, but 6 of 10 had a mild to moderate limp. Five patients returned to running initially; only two were able to keep running. Nine patients were brace-free initially (polio sequela required bracing initially), and four others returned to bracing. Of these, two experienced an acute “tearing” and dorsiflexion loss, one sustained a prolonged gradual loss of dorsiflexion, and one sustained a contralateral cerebrovascular accident. Only three of seven patients returned to active duty, and one is on jump status. All patients were satisfied with their initial result. Only two patients had no detectable swing phase problems (both returned to active duty). Five patients had peroneal nerve exploration with repair or neurolysis; two of them sustained complete transections. Postoperative electromyograms showed insignificant, if any, nerve return. The Riordan transfer works well for neuromuscular flaccid paresis and in patients with peroneal nerve injuries with low demands. It may stretch out over time to the point of acute failure in patients with high demands. Concurrent peroneal nerve exploration and repair did not seem to be beneficial in this small study.


1980 ◽  
Vol 239 (3) ◽  
pp. C58-C65 ◽  
Author(s):  
C. S. Hintz ◽  
C. V. Lowry ◽  
K. K. Kaiser ◽  
D. McKee ◽  
O. H. Lowry

Individual muscle fibers from the rat anterior tibialis and soleus muscles were each analyzed in duplicate for lactate dehydrogenase (LDH, EC 1.1.1.27), malate dehydrogenase (MDH, EC 1.1.1.37), 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35), fumarate hydrotase (EC 4.2.1.2), glycogen phosphorylase (EC 2.4.1.1), 6-phosphofructokinase (EC 2.7.1.11), pyruvate kinase (EC 2.7.1.40), fructose-bisphosphatase (EC 3.1.3.11), and creatine kinase (EC 2.7.3.2). A few fibers were also analyzed for adenylate kinase (EC 2.7.4.3). In general, there was a wide and almost continuous spectrum of coordinated enzyme activities. In the tibialis muscle, two fiber groups could be clearly distinguished on the basis of MDH activity. The high MDH group had on the average lower LDH activity, but there was a great deal of overlap in LDH between the two groups. Less overlap was observed for phosphorylase and fructose-bisphosphatase, both inversely related to MDH. Only one main group of fibers (presumably slow twitch) was found in the soleus muscle, although enzyme activities also covered a wide range. These soleus fibers were clearly distinguished from the high MDH tibialis group by much lower activities of LDH, pyruvate kinase, and fructose-bisphosphatase.


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