Comparative randomized study on the analgesic efficacy and side effects of iv PCA morphine versus a continuous infusion of a multimodal combination for cardiac surgery

Butorphanol (1 mg and 2 mg) and meperidine (40 mg and 80 mg), given intravenously, were evaluated for analgesic efficacy and safety in a double-blind randomized study employing 200 consenting pre-partum patients in moderate to severe pain during the late first stage of labour. Both drugs provided adequate relief of pain to the mothers. There was no significant difference in the rate of cervical dilation, the foetal heart rate, the Apgar score, pain relief or neonatal neurobehavioural scores between those receiving butorphanol and those receiving meperidine. Twenty-two mothers who received butorphanol and eleven who received meperidine nursed their infants with no adverse effects observed. Side-effects were generally infrequent in this study; however, more side-effects were reported by the patients and observed by the investigator in the meperidine-treated cases (13%) than in the cases treated with butorphanol (2%).

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A Comparison of Naproxen, Indomethacin and Acetylsalicylic Acid in Pain after Varicose Vein Surgery

Journal of International Medical Research ◽

10.1177/030006057800600216 ◽

1978 ◽

Vol 6 (2) ◽

pp. 152-156 ◽

Cited By ~ 6

Author(s):

Ulla Aromaa ◽

Kari Asp

Keyword(s):

Side Effects ◽

Acetylsalicylic Acid ◽

Postoperative Analgesia ◽

Varicose Vein ◽

Randomized Study ◽

Analgesic Efficacy ◽

Varicose Vein Surgery ◽

Double Blind ◽

Post Operative Pain ◽

Minor Surgery

Oral naproxen in doses of 500 mg and 750 mg daily was compared with oral indomethacin, 75 mg daily, in a double-blind, completely randomized study of patients with post-operative pain after out-patient varicose vein surgery. Altogether, 120 patients were studied. In the study 750 mg naproxen proved to be equal in respect of analgesic efficacy to 75 mg indomethacin, and it was clearly superior to 1500 mg acetylsalicylic acid. Naproxen, 500 to 750 mg daily, afforded adequate postoperative analgesia in 98% of patients. The side-effects were mild. On the basis of the study, naproxen can be recommended as a pain-relieving drug after minor surgery, particularly when an antiphlogistic effect is also desirable.

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Evaluation of the Adding Paracetamol to Dexmedetomidine in Pain Management After Adult Cardiac Surgery

Anesthesiology and Pain Medicine ◽

10.5812/aapm.110274 ◽

2021 ◽

Vol 11 (3) ◽

Author(s):

Fatemehshima Hadipourzadeh ◽

SeyedMehdi Mousavi ◽

Avaz Heydarpur ◽

Ali Sadeghi ◽

Rasool Ferasat-Kish

Keyword(s):

Cardiac Surgery ◽

Pain Management ◽

Side Effects ◽

Continuous Infusion ◽

Infusion Pump ◽

Postoperative Pain Control ◽

Drug Study ◽

Before And After ◽

Dexmedetomidine Infusion ◽

Adult Cardiac Surgery

Background: Postoperative pain control after cardiac surgery is usually based on Opioids. These drugs are associated with side effects, and the use of drugs with fewer side effects is important for analgesia. Dexmedetomidine and paracetamol have fewer side effects than opioids. Objectives: The aim of the study was to evaluate the adding paracetamol to dexmedetomidine continuous infusion pump for pain management after adult cardiac surgery. Methods: In this study, 100 patients were divided into two groups. One group received a continuous infusion of dexmedetomidine and paracetamol (DP), and the other received dexmedetomidine (D). These two groups were evaluated for MAP, HR, and the need for prescribing opioids before and after extubation. Also, duration of intubation and pain before extubation and 36 hours after every 4 hours. Results: Patients in the DP group had lower mean MAP and HR during intubation period than the D group and needed fewer opioids and doses of opioids in addition to drug study infusion pre- (P = 0.001) and post-extubation (P = 0.001 and P = 0.022, respectively). The DP group patients were extubated earlier (P = 0.001). After extubation, the DP group had less pain than the D group. Conclusions: This study showed that adding paracetamol to the dexmedetomidine infusion pump can provide better analgesia.

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Faculty Opinions recommendation of The postoperative analgesic efficacy of preperitoneal continuous wound infusion compared to epidural continuous infusion with local anesthetics after colorectal cancer surgery: a randomized controlled multicenter study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717964784.793469149 ◽

2013 ◽

Author(s):

Yiqian Nancy You ◽

Brian Keith Bednarski

Keyword(s):

Colorectal Cancer ◽

Continuous Infusion ◽

Multicenter Study ◽

Local Anesthetics ◽

Analgesic Efficacy ◽

Cancer Surgery ◽

Colorectal Cancer Surgery ◽

Randomized Controlled

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Faculty of 1000 evaluation for The role of different anesthetic techniques in altering the stress response during cardiac surgery in children: a prospective, double-blinded, and randomized study.

F1000 - Post-publication peer review of the biomedical literature ◽

10.3410/f.718007742.793479149 ◽

2013 ◽

Author(s):

Gregor Theilmeier ◽

Hans-Jörg Gillmann ◽

Jan Larmann

Keyword(s):

Cardiac Surgery ◽

Stress Response ◽

Randomized Study ◽

Anesthetic Techniques ◽

Double Blinded

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Faculty Opinions recommendation of Anticoagulant and side-effects of protamine in cardiac surgery: a narrative review.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.733133179.793545572 ◽

2018 ◽

Author(s):

Filip De Somer

Keyword(s):

Cardiac Surgery ◽

Side Effects ◽

Narrative Review

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High-dose Aprotinin in Cardiac Surgery—A Prospective, Randomized Study

Anaesthesia and Intensive Care ◽

10.1177/0310057x9402200505 ◽

1994 ◽

Vol 22 (5) ◽

pp. 529-533 ◽

Cited By ~ 20

Author(s):

M. J. Swart ◽

P. C. Gordon ◽

P. B. Hayse-Gregson ◽

R. A. Dyer ◽

A. L. Swanepoel ◽

...

Keyword(s):

Cardiac Surgery ◽

Placebo Group ◽

Blood Loss ◽

Artery Bypass ◽

Randomized Study ◽

Postoperative Blood Loss ◽

High Dose ◽

Maintenance Infusion ◽

Transfusion Requirements ◽

High Dose Aprotinin

Fifty patients undergoing primary coronary artery bypass surgery and 50 patients undergoing valve surgery received either high-dose aprotinin (2 million units loading dose, 2 million units added to the CPB prime, and 500,000 units/hr maintenance infusion) or placebo. Mean postoperative blood loss in the first six hours was reduced from 321 ml in the placebo group to 172 ml in the aprotinin group (95% confidence interval (CI) for difference = 95 to 189 ml). Seven patients in the placebo group and 16 patients in the aprotinin group did not require transfusion with homologous blood. This study adds to the growing body of evidence that the administration of high-dose aprotinin reduces blood loss and blood transfusion requirements associated with primary cardiac surgery.

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