PATTERN IDENTIFICATION/SYNDROME DIFFERENTIATION: GENETIC ASSOCIATION OF CODING REGION POLYMORPHISM OF PON1 AMONG KOREAN STROKE PATIENTS

2011 ◽  
Vol 29 ◽  
pp. e472-e473
Author(s):  
J. H. Lim ◽  
M. H. Cha ◽  
M. M. Ko ◽  
B. K. Kang ◽  
H. Y. Ko ◽  
...  
Keyword(s):  
Genetic Association ◽  
Pattern Identification ◽  
Syndrome Differentiation ◽  
Coding Region ◽  
Stroke Patients

scholarly journals Differential Association of Uncoupling Protein 2 Polymorphisms with Pattern Identification among Korean Stroke Patients: A Diagnostic System in Traditional Korean Medicine

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Ji Hye Lim ◽  
Mi Mi Ko ◽  
Hoyoung Lee ◽  
Ho Yeon Go ◽  
Tae-Woong Moon ◽  
...  
Keyword(s):  
Uncoupling Protein ◽  
Mitochondrial Protein ◽  
Diagnostic System ◽  
Cell Types ◽  
Pattern Identification ◽  
Uncoupling Protein 2 ◽  
Stroke Patients ◽  
Standard Pattern ◽  
Yin Deficiency ◽  
Predictive Parameters

Uncoupling protein 2 (UCP2), a mitochondrial protein present in many organs and cell types, is known to dissipate the proton gradient formed by the electron transport chain. Its function is correlated with predictive parameters, such as obesity, diabetes, and metabolic syndromes. We analyzed the distribution of UCP2 polymorphisms in stroke patients diagnosed with one of the following four stroke subtypes based on the TKM standard pattern identification (PI): Qi-deficiency (QD), Dampness and Phlegm (D&P), Yin-deficiency (YD), and Fire and Heat (F&D). We studied a total of 1,786 stroke patients (397/QD, 645/D&P, 223/YD, and 522/F&D, 586/normal). Genotyping for the G-1957A, G-866A and A55V UCP2 polymorphisms was performed using the TaqMan. G-866A and A55V were significantly associated with the D&P and H&F subtypes. The frequency of subjects with the A allele of G-866A was significantly lower than the frequency of subjects with the GG type. The A55V polymorphism was also shown similar effect with G-866A in the dominant model. In contrast, no SNPs were shown to be associated with the QD or YD subtypes in this study. These results showed that the G-866A and A55V UCP2 polymorphisms may be genetic factors for specific PI types among Korean stroke patients.

scholarly journals Clinical Approach to the Standardization of Oriental Medical Diagnostic Pattern Identification in Stroke Patients

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Han Jung Kim ◽  
Hyung Sup Bae ◽  
Seong Uk Park ◽  
Sang Kwan Moon ◽  
Jung Mi Park ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Blood Stasis ◽  
Diagnostic System ◽  
Binary Logistic Regression ◽  
Pattern Identification ◽  
Binary Logistic Regression Analysis ◽  
Clinical Approach ◽  
Stroke Patients ◽  
Logistic Equations ◽  
Yin Deficiency

In Korea, many stroke patients receive oriental medical care, in which pattern-identification plays a major role. Pattern-identification is Oriental Medicine's unique diagnostic system. This study attempted to standardize oriental medical pattern-identification for stroke patients. This was a community-based multicenter study that enrolled stroke patients within 30 days after their ictus. We assessed the patients' general characteristics and symptoms related to pattern-identification. Each patient's pattern was determined when two doctors had the same opinion. To determine which variables affect the pattern-identification, binary logistic regression analysis was used with the backward method. A total of 806 stroke patients were enrolled. Among 480 patients who were identified as having a certain pattern, 100 patients exhibited the Fire Heat Pattern, 210 patients the Phlegm Dampness Pattern, nine patients the Blood Stasis Pattern, 110 patients the Qi Deficiency Pattern, and 51 patients the Yin Deficiency Pattern. After the regression analysis, the predictive logistic equations for the Fire Heat, Phlegm Dampness, Qi Deficiency, and Yin Deficiency patterns were determined. The Blood Stasis Pattern was omitted because the sample size was too small. Predictive logistic equations were suggested for four of the patterns. These criteria would be useful in determining each stroke patient's pattern in clinics. However, further studies with large samples are necessary to validate and confirm these criteria.

scholarly journals Interobserver Reliability of Tongue Diagnosis Using Traditional Korean Medicine for Stroke Patients

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Mi Mi Ko ◽  
Ju Ah Lee ◽  
Byoung-Kab Kang ◽  
Tae-Yong Park ◽  
Jungsup Lee ◽  
...  
Keyword(s):  
Interobserver Agreement ◽  
Interobserver Reliability ◽  
Pattern Identification ◽  
University Hospitals ◽  
Stroke Patients ◽  
Traditional Korean Medicine ◽  
Fundamental Study ◽  
Korean Medicine ◽  
Tongue Diagnosis ◽  
Fur Quality

Observation of the tongue, also known as tongue diagnosis, is an important procedure in diagnosis by inspection in Traditional Korean medicine (TKM). We investigated the reliability of TKM tongue diagnosis in stroke patients by evaluating interobserver reliability regarding tongue indicators as part of the project named the Fundamental Study for the Standardization and Objectification of Pattern Identification in TKM for Stroke (SOPI-Stroke). A total of 658 patients with stroke admitted to 9 oriental medical university hospitals participated. Each patient was independently seen by two experts from the same department for an examination of the status of the tongue. Interobserver agreement about subjects regarding pattern identification with the same opinion between the raters (n=451) was generally high, ranging from “moderate” to “excellent”. Interobserver agreement was nearly perfect for certain signs of special tongue appearance (mirror, spotted, and bluish purple), poor for one of the tongue colors (pale) and moderate for others. Clinicians displayed measurable agreement regarding tongue indicators via both observation and pattern identification consistency. However, interobserver reliability regarding tongue color and fur quality was relatively low. Therefore, it is necessary to improve objectivity and reproducibility of tongue diagnosis through the development of detail-oriented criteria and enhanced training of clinicians.

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