Artificial Intelligence-Driven Algorithm for Drug Effect Prediction on Atrial Fibrillation: An in silico Population of Models Approach

Background: Antiarrhythmic drugs are the first-line treatment for atrial fibrillation (AF), but their effect is highly dependent on the characteristics of the patient. Moreover, anatomical variability, and specifically atrial size, have also a strong influence on AF recurrence.Objective: We performed a proof-of-concept study using artificial intelligence (AI) that enabled us to identify proarrhythmic profiles based on pattern identification from in silico simulations.Methods: A population of models consisting of 127 electrophysiological profiles with a variation of nine electrophysiological variables (GNa, INaK, GK1, GCaL, GKur, IKCa, [Na]ext, and [K]ext and diffusion) was simulated using the Koivumaki atrial model on square planes corresponding to a normal (16 cm2) and dilated (22.5 cm2) atrium. The simple pore channel equation was used for drug implementation including three drugs (isoproterenol, flecainide, and verapamil). We analyzed the effect of every ionic channel combination to evaluate arrhythmia induction. A Random Forest algorithm was trained using the population of models and AF inducibility as input and output, respectively. The algorithm was trained with 80% of the data (N = 832) and 20% of the data was used for testing with a k-fold cross-validation (k = 5).Results: We found two electrophysiological patterns derived from the AI algorithm that was associated with proarrhythmic behavior in most of the profiles, where GK1 was identified as the most important current for classifying the proarrhythmicity of a given profile. Additionally, we found different effects of the drugs depending on the electrophysiological profile and a higher tendency of the dilated tissue to fibrillate (Small tissue: 80 profiles vs Dilated tissue: 87 profiles).Conclusion: Artificial intelligence algorithms appear as a novel tool for electrophysiological pattern identification and analysis of the effect of antiarrhythmic drugs on a heterogeneous population of patients with AF.

Target group distribution pattern analysis with bagged convolutional neural networks for UAV distribution pattern identification

Purpose The purpose of this study is to address the limitations of existing target group distribution pattern analysis methods and identify subtle distribution differences within and between the groups with no pre-specified distribution features. Classical work generally concentrates on either the group distribution tendency or shape as a whole and simply ignores the subtle distribution differences within the group. Other work is constrained to pre-defined spatial distribution features. Design/methodology/approach This study proposes a novel algorithm for target group distribution pattern analysis. This study first transforms the group distribution data with uncertain measurements into a distributional image. Upon that, a bagged convolutional neural network model is constructed to discriminate the delicate group distribution patterns. Findings Experimental results indicate that our method is robust to target missing and location variance and scalable with dataset size. Our method has outperformed the benchmark machine learning methods significantly in pattern identification accuracy. Originality/value Our method is applicable for complex unmanned aerial vehicle distribution pattern identification.

Transformers analyzing poetry: multilingual metrical pattern prediction with transfomer-based language models

The splitting of words into stressed and unstressed syllables is the foundation for the scansion of poetry, a process that aims at determining the metrical pattern of a line of verse within a poem. Intricate language rules and their exceptions, as well as poetic licenses exerted by the authors, make calculating these patterns a nontrivial task. Some rhetorical devices shrink the metrical length, while others might extend it. This opens the door for interpretation and further complicates the creation of automated scansion algorithms useful for automatically analyzing corpora on a distant reading fashion. In this paper, we compare the automated metrical pattern identification systems available for Spanish, English, and German, against fine-tuned monolingual and multilingual language models trained on the same task. Despite being initially conceived as models suitable for semantic tasks, our results suggest that transformers-based models retain enough structural information to perform reasonably well for Spanish on a monolingual setting, and outperforms both for English and German when using a model trained on the three languages, showing evidence of the benefits of cross-lingual transfer between the languages.