DIFFERENCES IN POSTPRANDIAL HEMODYNAMIC RESPONSE ON A HIGH PROTEIN VERSUS A HIGH CARBOHYDRATE DIET

2011 ◽  
Vol 29 ◽  
pp. e525-e526
Author(s):  
J. Dopheide ◽  
J. M. Geleijnse ◽  
S. J.L. Bakker ◽  
E. J. Brink ◽  
M. A. Van Baak
1985 ◽  
Vol 54 (3) ◽  
pp. 567-575 ◽  
Author(s):  
H. C. Mehta ◽  
A. S. Saini ◽  
Harjit Singh ◽  
P. S. Dhatt

1. Sixty marasmic children were investigated for the absorption of xylose, proteins and fats. Their duodenal juice samples were also analysed for bile salts and microflora.2. The marasmic children were then studied in three groups of twenty by allocating them to three different dietary schedules: a high-protein diet (30% of the total energy from protein), a high-fat diet (40% of the total energy from fat) and a high-carbohydrate diet (70% of the total energy from carbohydrate) for 2 weeks and the previous measurements repeated.3. Whereas the high-fat diet resulted in improved fat absorption, along with an increase in total and conjugated bile acids, and the high-carbohydrate diet led to improved xylose absorption, the diet rich in protein resulted in an improvement in the absorption of all three dietary ingredients. It appears that a high-protein diet improves the overall absorption process by improving the intestinal environment as a whole, while high-carbohydrate and high-fat diets bring about adaptive changes related to the respective absorptive processes.


2017 ◽  
Vol 74 (10) ◽  
pp. 1564-1572 ◽  
Author(s):  
Rijan Bajracharya ◽  
Sonia Bustamante ◽  
John William O Ballard

Abstract Optimizing dietary macronutrients benefits the prevention and management of many human diseases but there is conflicting dietary advice for Parkinson’s disease (PD), and no single strategy is universally recommended. Recently, it was shown that dietary stearic acid (C18:0) improves survival and mitochondrial functions in the parkin null Drosophila model of PD. Here, we incorporate stearic acid into high protein and high carbohydrate diets and study survival, climbing ability, mitochondrial membrane potential, respiration, basal reactive oxygen species, and conduct lipidomics assays. We observed that parkin null flies showed improvement in all assays tested when stearic acid was added to the high protein diet but not to the high carbohydrate diet. When lipid proportion was examined, we observed higher levels in flies fed the high protein diet with stearic acid diet and the high carbohydrate diet. Unexpectedly, free levels of fatty acids exhibited opposite trend. Combined, these data suggest that dietary Protein: Carbohydrate ratio and stearic acid influences levels of bound fatty acids. The mechanisms that influence free and bound fatty-acid levels remain to be explored, but one possible explanation is that breakdown products can bind to membranes and improve the mitochondrial functions of parkin null flies.


Diabetologia ◽  
2004 ◽  
Vol 48 (1) ◽  
pp. 8-16 ◽  
Author(s):  
K. A. McAuley ◽  
C. M. Hopkins ◽  
K. J. Smith ◽  
R. T. McLay ◽  
S. M. Williams ◽  
...  

Metabolism ◽  
1994 ◽  
Vol 43 (12) ◽  
pp. 1481-1487 ◽  
Author(s):  
P.M. Piatti ◽  
L.D. Monti ◽  
Fulvio Magni ◽  
Isabella Fermo ◽  
L. Baruffaldi ◽  
...  

2019 ◽  
Author(s):  
Chrisabelle C. Mefferd ◽  
Shrikant S. Bhute ◽  
Jacqueline R. Phan ◽  
Jacob V. Villarama ◽  
Dung M. Do ◽  
...  

AbstractClostridioides difficile (formerly Clostridium difficile) infection (CDI) can result from the disruption of the resident gut microbiota. Western diets and popular weight-loss diets drive large changes in the gut microbiome; however, the literature is conflicted with regard to the effect of diet on CDI. Using the hypervirulent strain C. difficile R20291 (RT027) in a mouse model of antibiotic-induced CDI, we assessed disease outcome and microbial community dynamics in mice fed two high-fat diets in comparison with a high-carbohydrate diet and a standard rodent diet. The two high-fat diets exacerbated CDI, with a high-fat/high-protein, Atkins-like diet leading to severe CDI and 100% mortality, and a high-fat/low-protein, medium-chain triglyceride (MCT)-like diet inducing highly variable CDI outcomes. In contrast, mice fed a high-carbohydrate diet were protected from CDI, despite high refined carbohydrate and low fiber content. 28 members of the Lachnospiraceae and Ruminococcaceae decreased in abundance due to diet and/or antibiotic treatment; these organisms may compete with C. difficile for amino acids and protect healthy animals from CDI in the absence of antibiotics. Together, these data suggest that antibiotic treatment might lead to loss of C. difficile competitors and create a favorable environment for C. difficile proliferation and virulence that is intensified by high-fat/high-protein diets; in contrast, high-carbohydrate diets might be protective regardless of the source of carbohydrate.


1977 ◽  
Vol 38 (3) ◽  
pp. 385-395 ◽  
Author(s):  
C. B. Cowey ◽  
M. De La Higuera ◽  
J. W. Adron

1. The activities at 15° of three gluconeogenic enzymes, d-fructose-1,6-diphosphate, 1-phosphohydrolase (EC 3.1.3.11), pyruvate carboxylase (EC 6.4.1.1) and phosphoenolpyruvate carboxykinase (4.1.1.32), were determined in liver, kidney, gill and muscle of rainbow trout (Salmo gairdneri) given a commercial diet. The results indicated that liver and kidney are the main sites of gluconeogenesis.2. Glucose formation from pyruvate was approximately 6 μmol/h per g wet weight at 15° in liver slices of trout given a commercial diet.3. Glucose diffusion space in trout was measured by the dilution principle after intravascular injection of a trace dose of [U-14C]glucose. Glucose space was found to be 13.7% of the body-weight. Gluconeogenesis in vivo amounted to approximately 45 μmol/kg body-weight per h.4. Intraperitoneally injected [U-14C]alanine was quickly converted to glucose. Maximal incorporation of alanine into glucose occurred 6 h after alanine administration.5. Rainbow trout given a high-protein diet gained in weight significantly during a 4-week period. Those given a high-carbohydrate diet did not make a significant weight gain over the same period. Gluconeogenesis from alanine was markedly reduced in fish given the high-carbohydrate diet. There was no significant difference in gluconeogenesis from alanine in fish given a high-protein diet and fish which were fasted for 21 d.6. Gluconeogenesis from alanine in trout was suppressed by intravenous injection of insulin. This effect was found both in trout given a high-protein diet and in fasted trout.


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