Normal Ranges of Continuous pH Monitoring in the Proximal Esophagus

2000 ◽  
Vol 31 (3) ◽  
pp. 244-247 ◽  
Author(s):  
Beatrise Bagucka ◽  
Hegar Badriul ◽  
Kris Vandemaele ◽  
Elie Troch ◽  
Yvan Vandenplas
Keyword(s):  
Ph Monitoring ◽  
Proximal Esophagus ◽  
Normal Ranges ◽  
Continuous Ph Monitoring

708 A NEW DIAGNOSTIC PARADIGM FOR LARYNGOPHARYNGEAL REFLUX DISEASE: CORRELATION OF IMPEDANCE-PH MONITORING AND DIGITAL REFLUX SCINTIGRAPHY RESULTS

2021 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Jin-soo Park ◽  
Oleksandr Khoma ◽  
Hans Van Der Wall ◽  
Gregory Falk
Keyword(s):  
Laryngopharyngeal Reflux ◽  
Ph Monitoring ◽  
Acid Reflux ◽  
High Rate ◽  
High Yield ◽  
Time Activity ◽  
Proximal Esophagus ◽  
Laryngopharyngeal Reflux Disease ◽  
High Level ◽  
No Gold Standard

Abstract   No gold-standard investigation exists for laryngopharyngeal reflux (LPR). Multichannel intraluminal impedance (MII)-pH testing has uncertain utility in LPR. Meanwhile, reflux scintigraphy allows immediate and delayed visualisation of tracer reflux in the esophagus, pharynx, and lungs. The present study aimed to correlate MII-pH and scintigraphic reflux results in patients with primary LPR. Methods Consecutive patients with LPR underwent MII-pH and scintigraphic reflux studies. Abnormal values for MII-pH results were defined from existing literature. MII-pH and scintigraphic data were correlated. Results 105 patients with LPR (31 males (29.5%), median age 60 years (range: 20–87)) were studied. Scintigraphic reflux was seen in the pharynx in 94 (90.4%), and in the proximal esophagus in 94 (90.4%). Delayed scintigraphic contamination of the pharynx was seen in 101 patients (96.2%) and in the lungs of 56 patients (53.3%). Abnormal reflux was seen in the distal esophagus in 12.4%, proximal esophagus in 25.7%, and in the pharynx in 82.9%. Patients with poor scintigraphic clearance had higher Demeester scores (p = 0.043), more proximal reflux episodes (p = 0.046), more distal acid reflux episodes (p = 0.023), and longer bolus clearance times (p = 0.002). Conclusion Reflux scintigraphy has a high yield in LPR patients. Scintigraphic time-activity curves correlated with validated MII-pH results. A high rate of pulmonary microaspiration was found in LPR patients. This study demonstrated a high level of pharyngeal contamination by scintigraphy and MII-pH, which supports the use of digital reflux scintigraphy in diagnosing LPR.

Assessment of gastric acidity in intensive care patients: Intermittent pH registration cannot replace continuous pH monitoring

1996 ◽  
Vol 22 (3) ◽  
pp. 220-225 ◽  
Author(s):  
M. J. M. Bonten ◽  
C. A. Gaillard ◽  
R. W. Stockbrügger ◽  
F. H. van Tiel ◽  
S. van der Geest ◽  
...  
Keyword(s):  
Intensive Care ◽  
Gastric Acidity ◽  
Ph Monitoring ◽  
Intensive Care Patients ◽  
Continuous Ph Monitoring

scholarly journals A Study on the Influence of the Chemical Nature of Fillers on Rheological and Fatigue Behavior of Bitumen Emulsion Mastic

Materials ◽  
2020 ◽  
Vol 13 (20) ◽  
pp. 4627
Author(s):  
Ahmed Al-Mohammedawi ◽  
Konrad Mollenhauer
Keyword(s):  
Fatigue Damage ◽  
Ph Monitoring ◽  
Chemical Reactivity ◽  
Fatigue Behavior ◽  
Viscoelastic Behavior ◽  
Damage Resistance ◽  
Bitumen Emulsion ◽  
Continuous Ph Monitoring ◽  
Pavement Construction ◽  
The Impact

Cold Bitumen Emulsion (CBE) mixture technologies have been recently developed to lower pavement construction temperatures to reduce environmental costs and control gas emissions. Due to its poor early mechanical strength, active fillers (i.e., cement) have been used to obtain high early stiffness in order to have the potential for timely construction of the next layer. There is, however, a lack of understanding about the impact of active fillers on the viscoelastic behavior and fatigue damage resistance of CBE mastics. This study, therefore, aims to identify the influence of active fillers on the rheological properties and the resulting fatigue behavior of CBE mastic, supported by chemical analysis for the filler-bitumen emulsion. For this aim, bitumen emulsion was mixed separately with seven fillers/blended fillers to prepare the CBE mastics. Various experiments, including continuous pH monitoring tests (chemical reactivity of filler-bitumen emulsion), Strain Sweep (SS) tests, Temperature-Frequency Sweep (TFS) tests, Time Sweep (TS) tests, and Linear Amplitude Sweep (LAS) tests were conducted on the CBE binder and the prepared mastics. Results show that the rheological performance and the fatigue damage resistance depend not only on the filler inclusions but also on filler type and chemistry. On this basis, the rise in complex shear modulus and the decrease in the viscous component is associated with a significant enhancement in fatigue performance for specific fillers.

Evaluation of gastrointestinal transit times and pH in healthy cats using a continuous pH monitoring system

2021 ◽  
pp. 1098612X2110620
Author(s):  
Naila J Telles ◽  
Bradley T Simon ◽  
Elizabeth M Scallan ◽  
Emily N Gould ◽  
Mark G Papich ◽  
...  
Keyword(s):  
Monitoring System ◽  
Ph Monitoring ◽  
Gastrointestinal Transit ◽  
Individual Variability ◽  
Feeding Period ◽  
Non Invasive ◽  
Post Feeding ◽  
Transit Times ◽  
Gi Transit ◽  
Continuous Ph Monitoring

Objectives The aim of this study was to characterize gastrointestinal (GI) transit times and pH in healthy cats. Methods GI transit times and pH were measured in six healthy, colony-housed, purpose-bred spayed female cats using a continuous, non-invasive pH monitoring system in a sequential order design. For the first period (‘pre-feeding’), food was withheld for 20 h, followed by oral administration of a pH capsule. Five hours post-capsule administration, cats were meal-fed by offering them their daily allowance of food for 1 h. For the second period (‘post-feeding’), food was withheld for 24 h and cats were fed for 1 h, after which a pH capsule was orally administered. Studies in both periods were repeated three times. GI transit times and pH were compared between the two periods. Results The median transit times for the pre- and post-feeding periods, respectively, were: gastric –94 mins (range 1–4101) and 1068 mins (range 484–5521); intestinal –1350 mins (range 929–2961) and 1534 mins (range 442–2538); and GI –1732 mins (range 1105–5451) and 2795 mins (range 926–6563). The median GI pH values for the first and second periods, respectively, were: esophageal –7.0 (range 3.5–7.8) and 4.5 (range 2.9–6.4); gastric –2.7 (range 1.7–6.2) and 2.0 (range 1.1–3.3); intestinal –8.2 (range 7.6–8.7) and 7.8 (range 6.7–8.5); first-hour small intestinal –8.2 (range 7.4–8.7) and 8.3 (range 7.9–8.6); and last-hour large intestinal –8.5 (range 7.0–8.9) and 7.8 (range 6.3–8.7). Gastric ( P <0.0020) and intestinal pH ( P <0.0059) were significantly increased in the pre-feeding period compared with the post-feeding period. Conclusions and relevance Gastric and intestinal pH differed significantly when the capsule was administered 5 h prior to feeding compared with 1 h after feeding. Transit times for both periods showed high degrees of intra- and inter-individual variability.

Influence of Xanthines on Gastroesophageal Reflux in Infants at Risk for Sudden Infant Death Syndrome

PEDIATRICS ◽  
1986 ◽  
Vol 77 (6) ◽  
pp. 807-810 ◽  
Author(s):  
Yvan Vandenplas ◽  
D. De Wolf ◽  
L. Sacre
Keyword(s):  
At Risk ◽  
Gastroesophageal Reflux ◽  
Sudden Infant Death Syndrome ◽  
Infant Death ◽  
Ph Monitoring ◽  
Sudden Infant Death ◽  
Lower Esophageal Sphincter Pressure ◽  
Sudden Infant ◽  
Sphincter Pressure ◽  
Normal Ranges

Theophylline and caffeine are two drugs frequently administered to infants at risk for sudden infant death syndrome, because of their stimulatory effects on the respiratory system. These drugs are known to increase gastric acid secretion and to decrease lower esophageal sphincter pressure that, in turn, possibly increases gastroesophageal reflux (GER). Thirty babies were tested for GER before and during caffeine treatment. Eighteen were studied under the same conditions while undergoing theophylline treatment. All results of pH monitoring before treatment were within normal ranges. Episodes of GER increased significantly (P &lt; .001) in about 50% of the group treated with caffeine and in 66% of the group treated with theophylline. These results were independent of plasma xanthine concentrations (within or below therapeutic ranges) and of the efficacy of the drug. In addition, an increase was noted for the number of episodes of GER in 24 hours (from 5.3 to 17.1 in the caffeine group and from 5.3 to 24.3 in the theophylline group) and for the time pH was &lt; 4 (from 0.87% to 6% in the caffeine group and up to 13% in the theophylline group). Because GER is another known risk factor for sudden infant death syndrome, the administration xanthine derivatives in babies at risk for sudden infant death syndrome should be carefully considered in each case.

720 CONVENTIONAL AND SIMPLE METHODS OF MEASURING MEAN NOCTURNAL BASELINE IMPEDANCE SHOW EXCELLENT AGREEMENT

2021 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Jin-soo Park ◽  
Hans Van der Wall ◽  
Gregory Falk
Keyword(s):  
Excellent Agreement ◽  
Reflux Disease ◽  
Laryngopharyngeal Reflux ◽  
Ph Monitoring ◽  
Measurement Methods ◽  
Distal Esophagus ◽  
Simple Method ◽  
Proximal Esophagus ◽  
Predominant Symptom ◽  
Symptom Profile

Abstract   Mean nocturnal baseline impedance (MNBI) is a measurement that shows promise in investigating reflux disease by reflecting esophageal mucosal integrity. The conventional method of measuring MNBI is time-consuming and operator-dependent. A new, simple method of measuring MNBI has been suggested. This study aimed to report MNBI measurements by both conventional and simple methods in a cohort of laryngopharyngeal reflux (LPR) and gastro-esophageal reflux disease (GERD) patients to validate the simple measurement method. Methods 187 patients were divided into LPR (n = 105) or GERD (n = 82) groups by predominant symptom profile, and underwent off-therapy impedance-pH monitoring. MNBI was blindly measured by both conventional and simple methods, and values were correlated. Bland–Altman plots were constructed to assess mean differences and to identify bias between the two measurement methods. Results For the two measurement methods, mean difference in the distal esophagus was −89 (±328) ohms, in the proximal esophagus was −6 (±653) ohms, and in the pharynx was 128 (±577) ohms. There was strong correlation between conventional and simple MNBI values, with r = 0.940 in the distal esophagus, r = 0.463 in the proximal esophagus, and r = 0.712 in the pharynx (all p &lt; 0.001). Conclusion There was excellent agreement between conventional and simple methods of measuring MNBI, with no evidence of proportional bias. Conventional and simple MNBI values correlated excellently in the distal esophagus, and moderately well in the proximal esophagus and pharynx. This study supports the use of the simple method of measuring MNBI to enhance diagnosis of reflux disease.

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