Inhibition of the Cardiac p38-MAPK Pathway by SB203580 Delays Ischemic Cell Death

2000 ◽  
Vol 35 (3) ◽  
pp. 474-483 ◽  
Author(s):  
Miroslav Barancik ◽  
Patrik Htun ◽  
Claudia Strohm ◽  
Sven Kilian ◽  
Wolfgang Schaper
2008 ◽  
Vol 56 (1) ◽  
pp. 83-89 ◽  
Author(s):  
Ewa Jablonska ◽  
Wioletta Ratajczak ◽  
Jakub Jablonski

Author(s):  
Lingfan Xiong ◽  
Wenhao Guo ◽  
Yong Yang ◽  
Danping Gao ◽  
Jun Wang ◽  
...  

Phytomedicine ◽  
2014 ◽  
Vol 21 (12) ◽  
pp. 1746-1752 ◽  
Author(s):  
Ming-Ju Hsieh ◽  
Su-Yu Chien ◽  
Ying-Erh Chou ◽  
Chih-Jung Chen ◽  
Judy Chen ◽  
...  

2011 ◽  
Vol 300 (2) ◽  
pp. C375-C382 ◽  
Author(s):  
Chunhui Wang ◽  
Hua Xu ◽  
Huacong Chen ◽  
Jing Li ◽  
Bo Zhang ◽  
...  

Diarrhea is a common manifestation of gastrointestinal disorders. Diarrhea-induced losses of fluid and electrolyte could lead to dehydration and electrolyte imbalances, resulting in significant morbidity and mortality, especially in children living in developing countries. Somatostatin, a peptide hormone secreted by D-cells, plays an important role in regulating motility and intestinal Na+ absorption. Although octreotide, a somatostatin analog, is used to treat diarrhea, its mechanisms of action are unclear. Here we showed that octreotide increased brush-border membrane Na+/H+ exchanger 8 (NHE8) expression in the small intestine to the exclusion of other NHEs that participate in Na+ absorption. The same effect also occurred in human intestinal cells (Caco-2). We found that the increase of NHE8 expression by somatostatin required p38 mitogen-activated protein kinase (MAPK) activation. Furthermore, the somatostatin receptor SSTR2 antagonist CYN154806 could abolish somatostatin-induced NHE8 expression and p38 MAPK phosphorylation. Thus our data provided the first concrete evidence indicating that somatostatin stimulates intestinal Na+ absorption by increasing intestinal NHE8 expression through the SSTR2-p38 MAPK pathway.


2012 ◽  
Vol 6 (5) ◽  
pp. 1121-1125 ◽  
Author(s):  
YUANYUAN ZHANG ◽  
JIHUA LIU ◽  
JUNPING KOU ◽  
JUN YU ◽  
BOYANG YU

Inflammation ◽  
2012 ◽  
Vol 36 (3) ◽  
pp. 603-615 ◽  
Author(s):  
Juan Lei ◽  
Shengneng Xue ◽  
Wei Wu ◽  
Shuxian Zhou ◽  
Yuling Zhang ◽  
...  

2021 ◽  
Vol 12 (8) ◽  
pp. 3393-3404
Author(s):  
Qi-Zhang Li ◽  
Xin Chen ◽  
Pei-Wen Mao ◽  
Meng-Yuan Jin ◽  
Qin Wu ◽  
...  

The global health emergency generated by coronavirus disease-2019 has prompted the search for immunomodulatory agents.


Sign in / Sign up

Export Citation Format

Share Document