Nerve cell adhesion molecule expression in squamous cell carcinoma of the head and neck: A predictor of propensity toward perineural spread

1999 ◽  
Vol 109 (5) ◽  
pp. 821-826 ◽  
Author(s):  
Robert B. McLaughlin ◽  
Kathleen T. Montone ◽  
Stephen J. Wall ◽  
Ara A. Chalian ◽  
Gregory S. Weinstein ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Adhesion ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Nerve Cell ◽  
Squamous Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Adhesion Molecule Expression ◽  
Perineural Spread

Activated leukocyte cell adhesion molecule (ALCAM/CD166) expression in head and neck squamous cell carcinoma (HNSSC)

2014 ◽  
Vol 210 (10) ◽  
pp. 649-655 ◽  
Author(s):  
Till Sebastian Clauditz ◽  
Kirsten von Rheinbaben ◽  
Patrick Lebok ◽  
Sarah Minner ◽  
Michael Tachezy ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Adhesion ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Neck Squamous Cell Carcinoma

Expression of the cell-cell adhesion molecule E-cadherin in squamous cell carcinoma of the head and neck

2007 ◽  
Vol 18 (3) ◽  
pp. 196-201 ◽  
Author(s):  
GAYLE L. BOWIE ◽  
A.W. CASLIN ◽  
N.J. ROLAND ◽  
J.K.K. MA. FIELD ◽  
A.S. JONES ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Adhesion ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
E Cadherin ◽  
Cell Cell

Activated leukocyte cell adhesion molecule expression predicts lymph node metastasis in oral squamous cell carcinoma

Oral Oncology ◽  
2010 ◽  
Vol 46 (5) ◽  
pp. 393-398 ◽  
Author(s):  
Michiel van den Brand ◽  
Robert P. Takes ◽  
Marianne Blokpoel-deRuyter ◽  
Piet J. Slootweg ◽  
Léon C.L. van Kempen
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Adhesion ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Adhesion Molecule Expression ◽  
Node Metastasis

Correlation of Neural Cell Adhesion Molecules with Perineural Spread of Squamous Cell Carcinoma of the Head and Neck

2000 ◽  
Vol 122 (5) ◽  
pp. 717-720 ◽  
Author(s):  
Emre Vural ◽  
James Hutcheson ◽  
Soheila Korourian ◽  
Sofia Kechelava ◽  
Ehab Hanna
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Adhesion ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Adhesion Molecules ◽  
Squamous Cell ◽  
Cell Adhesion Molecules ◽  
Perineural Spread ◽  
Neural Cell Adhesion Molecules ◽  
Neural Cell Adhesion

Perineural spread (PNS) is a poor prognostic factor associated with increased risk of local recurrence and nodal metastasis and reduced survival of patients with squamous cell carcinoma of the head and neck (SCCHN). There is some evidence to indicate that neural cell adhesion molecules (NCAMs) may play a role in PNS of a variety of tumor types. We performed this study to investigate whether NCAM expression can be used as a predictor of PNS in SCCHN. The surgical specimens of 66 patients with SCCHN were evaluated with monoclonal IgG antibody immunoperoxidase staining for NCAM. Of the 41 specimens with PNS, 38 (93%) showed evidence of NCAM expression. In contrast, only 9 specimens (36%) without PNS expressed NCAMs. The difference in NCAM expression between the study and control groups was statistically significant ( P > 0.01).

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