Clinical features of differentiated thyroid carcinoma in children and adolescents from a sub-Himalayan iodine-deficient endemic zone

2001 ◽  
Vol 22 (8) ◽  
pp. 881-887 ◽  
Author(s):  
C. S. BAL ◽  
A. K. PADHY ◽  
A. KUMAR
Keyword(s):  
Thyroid Carcinoma ◽  
Children And Adolescents ◽  
Clinical Features ◽  
Differentiated Thyroid Carcinoma

Long-term follow-up of differentiated thyroid carcinoma in children and adolescents

2020 ◽  
Vol 33 (11) ◽  
pp. 1431-1441
Author(s):  
Montserrat Negre Busó ◽  
Amparo García Burillo ◽  
Marc Simó Perdigó ◽  
Pere Galofré Mora ◽  
Maria Boronat de Ferrater ◽  
...  
Keyword(s):  
Complete Remission ◽  
Thyroid Carcinoma ◽  
Children And Adolescents ◽  
Differentiated Thyroid Carcinoma ◽  
Radioiodine Treatment ◽  
Persistent Disease ◽  
Stage 4 ◽  
Long Term Follow Up

AbstractObjectivesThe aims were to analyze the clinical features, response to treatment, prognostic factors and long-term follow-up of children and adolescents with differentiated thyroid carcinoma (DTC).MethodsEighty patients with DTC were studied retrospectively. All underwent total or near-total thyroidectomy, and in 75 cases, ablative iodine therapy was recommended. Patients were assessed periodically by tests for serum thyroglobulin levels and whole-body iodine scans. Age, gender, initial clinical presentation, histology, tumor stage, postoperative complications, radioiodine treatment protocol, treatment response, thyroglobulin (Tg), recurrence and long-term disease progression were evaluated.ResultsSeventy patients completed >2 years of follow-up (23 males, 47 females; median age: 14 years; range: 3–18 years). Sixty-two patients showed papillary DTC and eight, follicular DTC. Sixty-five percent presented nodal metastasis and 16%, pulmonary metastasis at diagnosis. Six months after first radioiodine treatment, 36.2% of patients were free of disease. Seven recurrences were documented. At the end of follow-up, overall survival was 100%, and 87.2% of patients were in complete remission. Nine patients had persistent disease. We found a significant association between stage 4 and persistent disease. Hundred percent of patients with negative Tg values at 6 months posttreatment were documented free of disease at the end of the follow-up. The analysis of disease-free survival based on radioiodine treatment protocols used showed no statistically significant differences.ConclusionsDTC in children and adolescents is frequently associated with presence of advanced disease at diagnosis. Despite this, complete remission was documented after treatment in most cases, with a good prognosis in the long-term follow-up. Negative posttreatment thyroglobulin and stage 4 at diagnosis were significant prognostic variables.

scholarly journals Chronic lymphocytic thyroiditis is associated with invasive characteristics of differentiated thyroid carcinoma in children and adolescents

2015 ◽  
Vol 173 (6) ◽  
pp. 827-833 ◽  
Author(s):  
Paschalia K Iliadou ◽  
Grigoris Effraimidis ◽  
Michalakis Konstantinos ◽  
Panagiotou Grigorios ◽  
Periklis Mitsakis ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Carcinoma ◽  
Children And Adolescents ◽  
Differentiated Thyroid Carcinoma ◽  
Chronic Lymphocytic Thyroiditis ◽  
Long Term Outcome ◽  
Lymphocytic Thyroiditis ◽  
History Of ◽  
Histological Characteristics ◽  
Thyroid Parenchyma

BackgroundThe association between chronic lymphocytic thyroiditis (CLT) and thyroid cancer is an interesting topic. The aim of the present study was to evaluate if demographic and histological characteristics as well as the long-term outcome of thyroid cancer was different in children and adolescents with and without CLT.MethodsThe medical records of children and adolescents (≤21 years old) were reviewed. The following data were recorded: gender, year and age at diagnosis, family history of thyroid cancer, history of external radiation therapy, histological type (papillary and variants, follicular and variants), tumour size, multifocality, infiltration of thyroid parenchyma or surrounding soft tissues, vascular invasion, presence of lymph node and distant metastases. Information about the presence of TgAb and TPOAb was also collected.ResultsOne hundred eight children and adolescents (median age 19.0, interquartile range 4.0 years) were diagnosed with differentiated thyroid carcinoma (DTC); 31 patients (28.7%) presented histological characteristics compatible with CLT. Infiltration of thyroid parenchyma was more frequent in patients with CLT compared to patients without (74.2% vs 48.1% respectively, P=0.024). Familial papillary thyroid carcinoma (PTC) was more frequent in patients with CLT compared to those without CLT (20.7% vs 2.8% respectively, P=0.009). There was no better outcome with respect to the presence of CLT or not.ConclusionsChildren and adolescents with CLT present more frequently familial PTC as well as thyroid cancer with invasive characteristics.

scholarly journals Differentiated thyroid carcinoma in children and adolescents

1992 ◽  
Vol 16 (4) ◽  
pp. 547-553 ◽  
Author(s):  
Jay K. Harness ◽  
Norman W. Thompson ◽  
Michael K. McLeod ◽  
Janice L. Pasieka ◽  
Atsushi Fukuuchi
Keyword(s):  
Thyroid Carcinoma ◽  
Children And Adolescents ◽  
Differentiated Thyroid Carcinoma

scholarly journals Differentiated thyroid carcinoma presentation may be more aggressive in children and adolescents than in young adults

2018 ◽  
Vol 44 (1) ◽  
Author(s):  
Giuseppina Zirilli ◽  
Laura Cannavò ◽  
Francesco Vermiglio ◽  
Maria Antonia Violi ◽  
Filippo De Luca ◽  
...  
Keyword(s):  
Young Adults ◽  
Thyroid Carcinoma ◽  
Children And Adolescents ◽  
Differentiated Thyroid Carcinoma

Differentiated Thyroid Carcinoma in Pediatric Patients: Comparison of Presentation and Course between Pre-pubertal Children and Adolescents

2009 ◽  
Vol 154 (5) ◽  
pp. 708-714 ◽  
Author(s):  
Liora Lazar ◽  
Yael Lebenthal ◽  
Adam Steinmetz ◽  
Michal Yackobovitch-Gavan ◽  
Moshe Phillip
Keyword(s):  
Thyroid Carcinoma ◽  
Children And Adolescents ◽  
Pediatric Patients ◽  
Differentiated Thyroid Carcinoma

scholarly journals Chronic lymphocytic thyroiditis is associated with invasive characteristics of differentiated thyroid carcinoma in children and adolescents

2017 ◽  
Vol 177 (4) ◽  
pp. X1
Author(s):  
Paschalia K Iliadou ◽  
Grigoris Effraimidis ◽  
Michalakis Konstantinos ◽  
Panagiotou Grigorios ◽  
Periklis Mitsakis ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Children And Adolescents ◽  
Differentiated Thyroid Carcinoma ◽  
Chronic Lymphocytic Thyroiditis ◽  
Lymphocytic Thyroiditis

The features and diagnostics of differentiated thyroid carcinoma of children and adolescents

2016 ◽  
Vol 7 (3) ◽  
pp. 23-28 ◽  
Author(s):  
Yulia L Skorodok ◽  
Milena N Yakovleva ◽  
Aleksandr V Gostimsky ◽  
Lyudmila Alexandrovna Zhelenina
Keyword(s):  
Thyroid Carcinoma ◽  
Children And Adolescents ◽  
Clinical Symptoms ◽  
Fine Needle Biopsy ◽  
Needle Aspiration ◽  
Differentiated Thyroid Carcinoma ◽  
Fine Needle ◽  
Autoimmune Thyroid ◽  
Persistent Symptoms ◽  
Medical Examinations

The main purpose of research was to study and evaluate the featres and diagnosis of differentiated thyroid carcinoma of children and adolescents. The total of 63 patients with thyroid cancer who had undergone surgery in 1994-2013 in heir hildhood were examined. The history, clinical symptoms, results of pre- and postoperative instrumental and laboratory studies were analyzed. The research showed that three-quarters of thyroid carcinoma patients do not complain. Medical examinations of teenagers allowed to reveal the disease in more than half of cases. Significant place in the diagnostics of thyroid carcinoma occupies ultrasound and fine-needle biopsy (FNB). The most persistent symptoms of thyroid carcinoma are hypoechoic node and indistinct contours of node. The sensitivity of fine-needle aspiration biopsy in relation to thyroid carcinoma was 72.1%. Almost a quarter of patients with thyroid carcinoma combined it with autoimmune thyroid disorders.

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