Outcome and Reproductive Function After Conservative Surgery for Borderline Ovarian Tumors

e15508 Background: Borderline ovarian tumors, also called low-malignancy potential tumors, are infrequent tumors present predominantly in pre-menopause women. Their evolution after surgical treatment is generally very good. The main objective of this paper is to show the evolution of a group of borderline tumors treated at our institution. Methods: Between January 1, 2000 and January 1, 2010, 36 patients diagnosed with ovarian borderline tumors were examined by two independent pathologists, according to the guidelines established by the USA Association of Directors of Anatomic and Surgical Pathology. These patients were followed at IOHM and comprise this paper’s study group. Results: Population Characteristics: Mean Age: 41 years (Range: 20-85). Affected Ovary (Right: 17 pts; Left: 14 pts; Both: 5 pts). Pathology: Mucinous (17 pts), Serous (16 pts), Clear, Brenner and Endometroid Cells (1 pt each). Stages: IA (24 pts), IB (5 pts), IC (2pts), IIIA (4 pts), IIIC (1 pt). Five patients presented non-invasive peritoneal implants and three presented positive peritoneal liquid. All patients were surgically treated: 28 with total anexohisterectomy (TAH) and 8 with unilateral ooforectomy. No patient was given any chemotherapy or radiotherapy treatment. Four patients did not attend follow-up consultations and were lost after 4, 6, 12 and 29 months with no evidence of disease (NED). Thirty-two patients were followed bi-annually during the first five years and annually thereafter. One patient became pregnant after the surgery. All patients are alive and NED with an average follow up of 50 months (range: 29-133). Conclusions: 1) Although half the cases in the study were under 35 years old, there were 12 tumors present in patients over 50 years of age and 1 borderline tumor present in an 85 year old patient. 2) Surgically treated ovarian borderline tumors have a high chance of being curable without the need of chemotherapy or radiotherapy. 3) Conservative surgery in young patients allows a conservation of fertility, provided they are subject to an adequate follow-up.

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P1029 Clinical outcome of conservative surgery for borderline ovarian tumors with noninvasive implants and stage I disease

International Journal of Gynecology & Obstetrics ◽

10.1016/s0020-7292(09)62515-7 ◽

2009 ◽

Vol 107 ◽

pp. S702-S702

Author(s):

C. Jeong ◽

D. Jeong ◽

K. Lee ◽

M. Sung ◽

K. Kim

Keyword(s):

Clinical Outcome ◽

Conservative Surgery ◽

Ovarian Tumors ◽

Stage I ◽

Borderline Ovarian Tumors

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1145 Risk factors for recurrence of borderline ovarian tumors after conservative surgery: a multi center study by the francogyn group

10.1136/ijgc-2021-esgo.519 ◽

2021 ◽

Author(s):

A Ozenne ◽

R Emilie ◽

K Yohan ◽

C Akladios ◽

C Xavier ◽

...

Keyword(s):

Risk Factors ◽

Conservative Surgery ◽

Ovarian Tumors ◽

Borderline Ovarian Tumors ◽

Risk Factors For Recurrence ◽

Multi Center Study ◽

Center Study

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Survival and Reproductive Function After Treatment of Malignant Germ Cell Ovarian Tumors

Journal of Clinical Oncology ◽

10.1200/jco.2001.19.4.1015 ◽

2001 ◽

Vol 19 (4) ◽

pp. 1015-1020 ◽

Cited By ~ 147

Author(s):

Gerardo Zanetta ◽

Cristina Bonazzi ◽

Maria Grazia Cantù ◽

Sergio Bini† ◽

Anna Locatelli ◽

...

Keyword(s):

Survival Rate ◽

General Population ◽

Germ Cell ◽

Germ Cell Tumors ◽

Reproductive Function ◽

Conservative Surgery ◽

Ovarian Tumors ◽

Fertility Sparing ◽

Significant Difference

PURPOSE: Germ cell ovarian tumors are curable. The possible sequelae of chemotherapy on long-term survivors are still unknown, but these patients may expect normal lives. The aim of this study was to evaluate the outcome and reproductive function in a population of women treated since 1982. MATERIALS AND METHODS: Between 1982 and 1996, 169 women with malignant germ cell ovarian tumors were seen (70 dysgerminomas, 28 endodermal sinus tumors, 24 mixed tumors, and 47 immature teratomas). Seventy-one had advanced or recurrent disease. Fertility-sparing surgery was performed in 138 (81%) women, 81 of whom received postoperative chemotherapy. RESULTS: With a median follow-up of 67 months, the survival rate was 94% for dysgerminoma, 89% for endodermal sinus tumors, 100% for mixed types, and 98% for immature teratoma. For women who were treated conservatively, the survival rate was 98%, 90%, 100%, and 100%, respectively. Two women had adnexal recurrences, and both received salvage treatment. After treatment, all but one postpubertal woman had recovery of menses within 9 months. During follow-up, 12 untreated and 20 treated patients had 55 conceptions. We recorded 40 pregnancies at term, six terminations, and nine miscarriages. Four malformations were observed: one in 14 conceptions of patients who had not received chemotherapy and three in 41 conceptions of treated patients. CONCLUSION: Irrespective of subtype and stage, conservative surgery should become the standard approach to treating most patients with malignant ovarian germ cell tumors. Fertility seems to be only marginally affected by treatments. Miscarriages are in the expected range for the general population. The malformation rate is slightly higher than in the general population, but no significant difference was seen between patients who did and did not receive chemotherapy.

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The influence of clinical, pathological and surgical factors on the occurrence of recurrence of borderline ovarian tumors in different age groups

Tumors of female reproductive system ◽

10.17650/1994-4098-2019-15-2-57-61 ◽

2019 ◽

Vol 15 (2) ◽

pp. 57-61

Author(s):

F. V. Novikov ◽

V. P. Bondarev ◽

E. S. Mishina ◽

M. V. Mnikhovich

Keyword(s):

Age Groups ◽

Reproductive Function ◽

Ovarian Tumors ◽

Reproductive Age ◽

High Survival ◽

Non Invasive ◽

Borderline Ovarian Tumors ◽

First Case ◽

Biological Potential

Background. Borderline ovarian tumors (BOT), due to their unclear biological potential, remain a problem for oncogynecologists. On the one hand, frequent recurrences of tumors, and on the other hand, a high survival rate in the diagnosis of patients requires careful weighing of all risk factors when choosing surgical intervention tactics in patients with BOT. A large number of recurrences of BOT in patients of fertile age lead to disability of patients, deterioration of their quality of life and loss of reproductive function.Objective: evaluation of the influence of clinical and morphological factors (the presence of non-invasive implants, bilateral lesion of the ovaries, the presence of psammous bodies and malignization tricks) and surgical factors (damage to the cyst capsule and carrying out fertility preserving operations) on the recurrence of BOT in various age groups.Materials and methods. The material for the study was the protocols of an in vivo pathoanatomical study of a biopsy (surgical) material obtained from patients with a diagnosis of BOT for the period from 2000 to 2017 inclusive, according to the Regional Forensic Medical Bureau of Kursk. A total of 110 protocols for the first occurrence of BOT and 14 protocols for the tumor recurrences were analyzed. The age of patients undergoing an in vivo pathologic examination ranged from 19 to 75 years.Results and conclusions. It has been revealed that psammous bodies, fertility preserving operations and reproductive age are associated with tumor recurrence. Groups of patients with foci of malignancy and bilateral lesions have a lower risk of BOT recurrence due to the radical surgical treatment tactics and possibly the use of chemotherapy in the first case. Non-invasive implants are not associated with the risk of BOT recurrence.

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