Value of cerebrospinal fluid leukocyte aggregation in distinguishing the causes of meningitis in children

2000 ◽  
Vol 19 (1) ◽  
pp. 66-72 ◽  
Author(s):  
IAN C. MICHELOW ◽  
MARK NICOL ◽  
CAROLINE TIEMESSEN ◽  
CLAUDIA CHEZZI ◽  
JOHN M. PETTIFOR
Keyword(s):  
Cerebrospinal Fluid ◽  
Leukocyte Aggregation ◽  
Meningitis In Children

scholarly journals Correlation between leukocyte aggregation score of cerebrospinal fluid and bacterial meningitis in children

2016 ◽  
Vol 44 (2) ◽  
pp. 61
Author(s):  
Meitha PE Togas ◽  
Nurhayati Masloman
Keyword(s):  
Cerebrospinal Fluid ◽  
Child Health ◽  
Bacterial Meningitis ◽  
Medical School ◽  
General Hospital ◽  
The Other ◽  
Life Threatening ◽  
Leukocyte Aggregation ◽  
The Mean ◽  
Meningitis In Children

Background Bacterial meningitis is one of life-threatening dis-eases and carries a risk of sequelae in affected children. In termsof cost and rapid differentiation between bacterial and non-bacte-rial meningitis, several tests have been proposed.Objective This study aimed to determine the use of leukocyteaggregation score (LAS) of cerebrospinal fluid (CSF) in diagnos-ing bacterial meningitis.Methods A prospective analytic study was done from October 2001to July 2002 in the Department of Child Health, Medical School,Sam Ratulangi University/ Manado General Hospital. Children pre-senting with symptoms of meningitis, aged between 28 days and13 years were enrolled. LAS was counted in percentage. Regres-sion analysis was used to determine the correlation between LASand diagnosis of bacterial meningitis.Results CSF examinations were done on 35 meningitis patients.Three patients were excluded. The remaining 32 patients com-prised of 11 with bacterial meningitis and the other 21 with non-bacterial meningitis. The mean of LAS in bacterial meningitis wassignificantly higher than that of non-bacterial meningitis (p<0.001).The cut off value of LAS to diagnose bacterial meningitis was12.35%.Conclusion LAS may be used as a fast and simple alternativediagnostic tool to confirm the diagnosis of bacterial meningitis

scholarly journals CLINICAL-EPIDEMIOLOGICAL CHARACTERISTICS OF ASEPTIC MENINGITIS IN CHILDREN OF KHMELNITSKYI REGION (PODILSKYI REGION, UKRAINE): FOURTEEN-YEAR EPIDEMIOLOGICAL OBSERVATION

2019 ◽  
Vol 11 (1) ◽  
pp. 41-45
Author(s):  
L. V. Pypa ◽  
R. V. Svistilnik ◽  
Yu. N. Lysytsia ◽  
K. Yu. Romanchuk ◽  
I. V. Odarchuk
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Aseptic Meningitis ◽  
Clinical Picture ◽  
Epileptic Seizures ◽  
Complete Recovery ◽  
The Central Nervous System ◽  
Meningitis In Children ◽  
Epidemiological Characteristics

Aim of work – to analyze the etiological structure, epidemiological structure, social-demographic features and the nature of the development of complications of the central nervous system in aseptic meningitis in children in Khmelnitskyi region for the period 2004-2017.Materials and methods. It was conducted a prospective analysis of 208 cases of aseptic meningitis in children of whom 138 people were boys and 70 people were girls. The etiology of the disease was determined by studying cerebrospinal fluid using PCR method. Complications of the central nervous system were diagnosed on the basis of the clinical picture and CT or MRI scans. The analytical method was used to conduct the analysis of the received data.Results. The highest seasonal increase of the incidence was from August to October and it was 65.6% with its peak in September (24.0%). The clinical picture was characterized by a moderate trend in 71.2% of cases and in 28.8% by a severe course. In 100% of cases the disease began with a fever, headache (83.6%), vomiting (76.9%), abdominal pain with diarrhea (6.2%), epileptic seizures (0.9%). The average level of cytosis was 269.4±196.7 cells/mm3with a predominance of lymphocytes and the average protein level in cerebrospinal fluid was 73 ± 36 mg/dl. The etiological factor was established in 18 (8.6%) patients.Conclusions. Enterovirus remains to be the main pathogen which was determined in 72.2% of cases. The second place was taken by herpes viruses (22.2% of cases), the third place was given to the mumps virus (5.6% of cases) (in etiologically verified cases). In most cases the disease ended in complete recovery but in 47 (22.6%) patients the complications were observed. The prevalence of aseptic meningitis among children in Khmelnitskyi region was 6.2 per 100,000 children, and males outnumbered females by a 2:1 ratio.

Normal Cerebrospinal Fluid Values

PEDIATRICS ◽  
1985 ◽  
Vol 76 (6) ◽  
pp. 1023-1024
Author(s):  
MATTHEW J. CORY
Keyword(s):  
Cerebrospinal Fluid ◽  
Bacterial Meningitis ◽  
Chart Review ◽  
Febrile Child ◽  
Cns Disease ◽  
Csf Pleocytosis ◽  
Meningitis In Children

To the Editor.— I read with interest the article, "Normal Cerebrospinal Fluid Values in Children: Another Look," by Portnoy and Olson (Pediatrics 1985;75:484-487). Their data certainly have relevance to the problem of interpretation of minimal pleocytosis discovered in the evaluation of the febrile child. Perhaps, because they excluded patients with CNS disease from chart review, they failed to find an additional useful piece of information, ie, the incidence of bacterial meningitis in children with the same or similar CSF pleocytosis.

Diagnostic Value of Clinical and Laboratory Findings in Childhood Meningitis

2019 ◽  
Vol 15 (02) ◽  
pp. 079-085
Author(s):  
Melike Emiroglu ◽  
Recep Kesli ◽  
Murat Kilicaslan
Keyword(s):  
Cerebrospinal Fluid ◽  
Statistical Analysis ◽  
Bacterial Meningitis ◽  
Diagnostic Value ◽  
Human Enterovirus ◽  
Study Patient ◽  
Laboratory Findings ◽  
Cell Counts ◽  
Acute Meningitis ◽  
Meningitis In Children

Abstract Objective Acute meningitis in childhood is a serious infectious disease that requires immediate medical assessment to ensure appropriate treatment and healthy outcomes. The aim of this retrospective study was to evaluate clinical and laboratory findings in the diagnosis of acute meningitis in children. Materials and Methods Between February 2011 and March 2013, 258 children aged between 1 month and 18 years who were admitted to Konya Training and Research Hospital, Turkey, with clinically suspected meningitis and undergoing lumbar puncture were enrolled in the study. Patient charts were reviewed using a standardized data collection tool. Fifty-nine patients were excluded because of incomplete data or because they did not meet the enrollment criteria. Further statistical analysis was conducted on the remaining 199 patients. The diagnostic values of clinical and laboratory findings for acute meningitis were investigated. IBM SPSS 21.0 for Windows was used for the statistical analysis. Results Of the 199 patients (61.3% male; median age: 24 months), 101 (50.8%) were diagnosed with meningitis. A definitive diagnosis of bacterial meningitis was made in 16 patients, while 5 patients had probable bacterial meningitis. In addition, 80 patients diagnosed as aseptic meningitis and 47 of these patients had human enterovirus meningitis. Headache was more common in patients with meningitis. In patients without meningitis, the most common complaints were seizures or seizures accompanied by fever. Erythrocyte sedimentation rates (ESR), levels of cerebrospinal fluid protein, and cell counts in cerebrospinal fluid examinations were higher in the meningitis group. C-reactive protein, ESR, and procalcitonin higher than 22.55 mg/L, 36.5 mm/hour, and 6.795 mg/mL, respectively, indicated bacterial meningitis. Conclusion Our results showed that a combination of clinical and laboratory markers could facilitate recognition of bacterial meningitis in children.

scholarly journals OC 8277 IDENTIFICATION OF NEW CEREBROSPINAL FLUID AND BLOOD-BASED BIOMARKERS FOR THE DIAGNOSIS OF TUBERCULOUS MENINGITIS IN CHILDREN

2019 ◽  
Vol 4 (Suppl 3) ◽  
pp. A3.2-A3
Author(s):  
Masilo Charles Manyelo ◽  
Regan S Solomons ◽  
Gerhard Walzl ◽  
Novel N Chegou
Keyword(s):  
Cerebrospinal Fluid ◽  
Tuberculous Meningitis ◽  
Point Of Care ◽  
Extrapulmonary Tuberculosis ◽  
Diagnostic Delay ◽  
Severe Form ◽  
High Morbidity ◽  
Serum Samples ◽  
Meningitis In Children ◽  
Study Participants

BackgroundTuberculous meningitis (TBM) is the most severe form of extrapulmonary tuberculosis (TB). It mostly affects young children and results in high morbidity and mortality, mainly due to diagnostic delay. There is an urgent need for new tests for the earlier and accurate diagnosis of the disease. We previously identified a 3-marker cerebrospinal fluid (CSF) biosignature (VEGF, IL-13, and LL-37) with potential to diagnose TBM. In the present study, we show that CSF and blood-based biosignatures may be useful in the diagnosis of TBM.MethodsCSF and serum samples were consecutively collected from 47 children that were admitted to the Tygerberg Academic Hospital in Cape Town, South Africa, on suspicion of having TBM. Using a multiplex platform, the concentrations of 69 host markers were evaluated in the CSF and serum samples from all the study participants, followed by statistical analysis to ascertain the usefulness of these biomarkers as diagnostic candidates for TBM disease.ResultsOut of the 47 study participants, 23 (48.9%) were finally diagnosed with TBM and 6 (12.8%) were infected with HIV. Several CSF and serum biomarkers showed potential individually as diagnostic candidates for TBM as ascertained by area under the receiver operator characteristics curve (AUC). However, the main findings of our study were the identification of a four-marker CSF biosignature which diagnosed TBM with an AUC of 0.97 (95% CI, 0.92–1.00), and a 3-marker serum biosignature which diagnosed TBM with an AUC of 0.84 (95% CI, 0.73–0.96). We also validated a previously identified 3-marker CSF biosignature (VEGF, IL13 and LL37) in the study.ConclusionCSF and serum biosignatures may be useful in the diagnosis of TBM in children. Our findings require further validation in larger, multi-site studies after which the biosignatures may be incorporated into point-of-care diagnostic tests for TBM.

Cerebrospinal fluid leukocyte aggregation in meningitis

1997 ◽  
Vol 16 (7) ◽  
pp. 647-651 ◽  
Author(s):  
BEN-ZION GARTY ◽  
SHLOMO BERLINER ◽  
ELIEZER LIBERMAN ◽  
YEHUDA L. DANON
Keyword(s):  
Cerebrospinal Fluid ◽  
Leukocyte Aggregation

Haemophilus influenzae infections of cerebrospinal fluid shunts

1981 ◽  
Vol 54 (2) ◽  
pp. 261-263 ◽  
Author(s):  
Stephen J. Lerman
Keyword(s):  
Cerebrospinal Fluid ◽  
Haemophilus Influenzae ◽  
Clinical Presentation ◽  
Shunt Infection ◽  
Antibiotic Administration ◽  
Cerebrospinal Fluid Shunts ◽  
Content Type ◽  
Systemic Antibiotic Therapy ◽  
The Central Nervous System ◽  
Meningitis In Children

✓ Two (1%) of 165 episodes of Haemophilus influenzae infection of the central nervous system occurred in patients with cerebrospinal fluid shunts. Both cases were caused by strains that could not be typed. The clinical presentation was similar to that of other forms of shunt infection, yet the pathogenesis may be similar to that of H. influenzae meningitis in children without shunts. Systemic antibiotic therapy, without shunt replacement or intraventricular antibiotic administration, may be more successful in shunt infections caused by H. influenzae than in those caused by other organisms.

scholarly journals CEREBROSPINAL FLUID LACTATE IN MENINGITIS IN CHILDREN

2017 ◽  
Vol 4 (80) ◽  
pp. 4743-4746
Author(s):  
Bindu Krishnan Padma ◽  
Deepa Kunju Krishnan
Keyword(s):  
Cerebrospinal Fluid ◽  
Meningitis In Children
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