COL9A3 Gene Polymorphism and Obesity in Intervertebral Disc Degeneration of the Lumbar Spine: Evidence of Gene-Environment Interaction

Spine ◽  
2002 ◽  
Vol 27 (23) ◽  
pp. 2691-2696 ◽  
Author(s):  
Svetlana Solovieva ◽  
Jaana Lohiniva ◽  
Päivi Leino-Arjas ◽  
Raili Raininko ◽  
Katariina Luoma ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Gene Polymorphism ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Environment Interaction ◽  
Gene Environment Interaction ◽  
Gene Environment

scholarly journals Validity and interobserver agreement of a new radiographic grading system for intervertebral disc degeneration: Part I. Lumbar spine

2005 ◽  
Vol 15 (6) ◽  
pp. 720-730 ◽  
Author(s):  
Hans-Joachim Wilke ◽  
Friederike Rohlmann ◽  
Cornelia Neidlinger-Wilke ◽  
Karin Werner ◽  
Lutz Claes ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Interobserver Agreement ◽  
Grading System ◽  
Radiographic Grading

scholarly journals Validity and interobserver agreement of a new radiographic grading system for intervertebral disc degeneration: Part I. Lumbar spine

2006 ◽  
Vol 15 (6) ◽  
pp. 731-731 ◽  
Author(s):  
Hans-Joachim Wilke ◽  
Friederike Rohlmann ◽  
Cornelia Neidlinger-Wilke ◽  
Karin Werner ◽  
Lutz Claes ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Interobserver Agreement ◽  
Grading System ◽  
Radiographic Grading

scholarly journals Comparison of MRI cross-sectional area and functions of core muscles among asymptomatic individuals with and without lumbar intervertebral disc degeneration

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Gyeong-tae Gwak ◽  
Ui-jae Hwang ◽  
Sung-hoon Jung ◽  
Hyun-a Kim ◽  
Jun-hee Kim ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Cross Sectional Area ◽  
Sectional Area ◽  
Endurance Test ◽  
Cross Sectional ◽  
Significant Difference ◽  
Asymptomatic Individuals

Abstract Background Previous studies suggested that patients with symptomatic intervertebral disc degeneration (IDD) of lumbar spine have reduced cross-sectional area (CSA) and functions of core muscles. However, reduced CSA and functions of core muscles have been observed not only in patients with symptomatic IDD but also in patients with other subgroups of low back pain (LBP). Thus, it is uncertain whether reduced CSA and functions of core muscles lead to IDD and LBP, or pain leads to reduced CSA and functions of core muscles in patients with symptomatic IDD. Therefore, this study aimed to compare the CSA and functions of core muscles between asymptomatic participants with and without IDD in magnetic resonance imaging (MRI). Methods Twenty asymptomatic participants (12 men and 8 women) participated in this study. Ten participants had asymptomatic IDD at L4–5. The others were healthy controls (without IDD at all levels of lumbar spine). The CSA of core muscles was measured using MRI. Maximal isometric trunk flexor strength and side bridge strength were measured by a Smart KEMA strength sensor. Trunk flexor endurance test, side bridge endurance test and plank endurance test were used to measure core endurance. Double legs loading test was used to measure core stability. Mann-Whitney U test was used to compare the differences between two groups. Results There were no significant differences in core muscle functions between the two groups (p > 0.05). Moreover, there was no significant difference in CSA between the two groups (p > 0.05). Conclusions There was no significant difference in CSA and core muscle functions between asymptomatic participants with and without IDD. These findings indicate that a degenerative or bulging disc in asymptomatic individuals has little effect on CSA and functions of core muscles, especially in young age. Therefore, the general core endurance test or strength test could not differentiate asymptomatic people with and without IDD of lumbar spine. Trial registration number Clinical Research information Service. KCT0004061. Registered 13 June 2019. retrospectively registered.

Effects of motion segment level, Pfirrmann intervertebral disc degeneration grade and gender on lumbar spine kinematics

2016 ◽  
Vol 34 (8) ◽  
pp. 1389-1398 ◽  
Author(s):  
Muturi G. Muriuki ◽  
Robert M. Havey ◽  
Leonard I. Voronov ◽  
Gerard Carandang ◽  
Michael R. Zindrick ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Motion Segment ◽  
Spine Kinematics ◽  
And Gender

The Role of Gene–Environment Interaction in Determining Bone Mineral Density in a Twin Population

2007 ◽  
Vol 10 (1) ◽  
pp. 191-197 ◽  
Author(s):  
Vasi Naganathan ◽  
Alexander J. MacGregor ◽  
Philip N. Sambrook
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Environmental Factors ◽  
Bone Mineral ◽  
Genetic Component ◽  
Total Variance ◽  
Environment Interaction ◽  
Mineral Density ◽  
Gene Environment Interaction ◽  
Gene Environment

AbstractThe possibility that specific environmental factors such as smoking and estrogen use modify the genetic influences (gene–environment interaction) on bone mineral density (BMD) has not been explored in genetic epidemiological studies such as twin studies. The aim of this study was to look for evidence of gene–environment interaction in BMD determination by analyzing data collected on a large number of healthy female twins. BMD of the hip, distal forearm and lumbar spine were measured by dual-energy X-ray absorptiometry on 287 identical and 265 nonidentical volunteer female twin pairs. The environmental factors examined were hormone replacement therapy (HRT) and smoking. In genetic modeling analysis using path analysis, there was evidence of ‘HRT-specific’ genetic component of BMD variance at the forearm (50% of total variance) but not at the hip. At the lumbar spine the magnitude of the genetic component of variance in HRT users (> 60-month HRT use) was less than the genetic component of variance for little or no exposure to HRT (48% vs. 84%). There was no evidence of gene–environment interaction for smoking. The main evidence for gene–environment interaction was the finding that forearm BMD variance was influenced by a significant HRT-specific genetic component. There was also evidence that in HRT users, the genetic component of total variance for lumbar BMD was lower.

scholarly journals The effect of training on lumbar spine posture and intervertebral disc degeneration in active-duty Marines

Ergonomics ◽  
2016 ◽  
Vol 60 (8) ◽  
pp. 1055-1063 ◽  
Author(s):  
Ana E. Rodriguez-Soto ◽  
David B. Berry ◽  
Rebecca Jaworski ◽  
Andrew Jensen ◽  
Christine B. Chung ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Active Duty

The association of aggrecan gene polymorphism with the risk of intervertebral disc degeneration

2010 ◽  
Vol 153 (1) ◽  
pp. 129-133 ◽  
Author(s):  
Nam Keun Kim ◽  
Dong Ah Shin ◽  
In Bo Han ◽  
Eun Hye Yoo ◽  
Sang Heum Kim ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration

scholarly journals Correlation Analysis of Intervertebral Disc Degeneration with HTRA1 and HAPLN1 Gene Polymorphisms

2020 ◽  
Vol 4 (5) ◽  
Author(s):  
Tuanmao Guo ◽  
Yanli Xing ◽  
Zhongning Chen ◽  
Haiyun Zhu
Keyword(s):  
Back Pain ◽  
Lumbar Spine ◽  
Correlation Analysis ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Gene Polymorphisms ◽  
Intervertebral Disc Degeneration ◽  
Clinical Manifestations ◽  
Degenerative Changes ◽  
Leg Pain

The lumbar spine, an important part of the body's motor mechanism, is more susceptible to damage as it bears most of the body's load. Age can cause clinical manifestations such as neurological impairment, back and leg pain in the lumbar spine. External forces result in nucleus pulposus out, destruction of the intervertebral disc fibrous ring, and gradual aging and damage. Lumbar degenerative change is a common middle-aged and old-aged disease, and its clinical symptoms on the initial stage are not obvious, but it becomes more and more serious as they get older. Patients with severe lumbar degenerative changes will appear symptoms such as urinary and fecal incontinence, lower extremity numbness, back pain, and sexual dysfunction. The main reason for back pain and leg pain is the degenerative changes in the lumbar intervertebral discs, at the same time which also leads to patients' lumbar instability. This study focuses on the correlation analysis of intervertebral disc degeneration with HTRA1 and HAPLN1 gene polymorphisms.

Potential role of vitamin D receptor gene polymorphism in determining bone phenotype in young male athletes

2002 ◽  
Vol 93 (6) ◽  
pp. 1973-1979 ◽  
Author(s):  
Orie Nakamura ◽  
Tomoo Ishii ◽  
You Ando ◽  
Hitoshi Amagai ◽  
Masakazu Oto ◽  
...  
Keyword(s):  
Vitamin D ◽  
Lumbar Spine ◽  
Femoral Neck ◽  
Mineral Content ◽  
Young Male ◽  
Environment Interaction ◽  
Male Athletes ◽  
Gene Environment Interaction ◽  
Gene Environment

The genetic difference among individuals partly explains variance in adaptive response to exercise through gene-environment interaction. The aim of this cross-sectional study was to evaluate the role of the vitamin D receptor (VDR) gene polymorphism, which locates at the translation initiation site, in the adaptations of bone to long-term impact loading. The VDR genotypes, as detected by endonuclease FokI, and bone phenotypes of the lumbar spine and femoral neck were examined in 44 highly trained young male athletes and 44 age-matched nonathletic controls. As a whole, the athletes had a significantly higher bone mineral content resulting from a combination of increased volume and density at both sites than the controls. When the athletes were compared with the controls within each VDR genotype, however, the increased spinal volume was found only in the athletes with the FF but not in those with the Ff genotype(“F” for the absence of the endonuclease Fok I restriction site and “f” for its presence). Differences in bone mineral content in the lumbar spine and femoral neck between the controls and the athletes were greater in subjects with FF than those with Ff. Our results suggest a gene-environment interaction in that the bone phenotypes in individuals with FF adapt to impact loading by producing stronger bone structure than those with the Ff do.

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