50 ANALYTICAL CHARACTERIZATION OF THE PRO-TRAC™ II ELISA FOR THE DETERMINATION OF TACROLIMUS IN WHOLE BLOOD

1997 ◽  
Vol 19 (5) ◽  
pp. 559
Author(s):  
G. MacFarlane ◽  
D. Scheller ◽  
D. Ersfeld ◽  
B. Fox ◽  
J. Obritsch ◽  
...  
Keyword(s):  
Whole Blood ◽  
Analytical Characterization

Applications of the Global Coordinate System

2011 ◽  
Author(s):  
Yves Balasko
Keyword(s):  
Coordinate System ◽  
Critical Points ◽  
Global Coordinate System ◽  
Coordinate Systems ◽  
Analytical Characterization ◽  
Equilibrium Manifold ◽  
System P ◽  
Definition Of

The global coordinate system for the equilibrium manifold follows from: (1) the determination of the unique fiber F(b) through the equilibrium (ρ‎, ω‎) where b = φ‎((ρ‎, ω‎) = (ρ‎, ρ‎ · ρ‎1, …, ρ‎ · ρ‎m); and (2) the determination of the location of the equilibrium (ρ‎, ω‎) within the fiber F(b) viewed as a linear space of dimension (ℓ − 1)(m − 1) and, therefore, parameterized by (ℓ − 1)(m − 1) coordinates. If there is little leeway in determining the fiber F(b) through the equilibrium (ρ‎, ω‎), there are different ways of representing the equilibrium (ρ‎, ω‎) within its fiber F(b). This leads to the definition of coordinate systems (A) and (B) for the equilibrium manifold. This chapter defines these two coordinate systems and applies them to obtain an analytical characterization of the critical equilibria, i.e., the critical points of the natural projection.

Experimental and analytical characterization of reinforced polyurethanes

2019 ◽  
pp. 540-544
Author(s):  
I.E. Semenov
Keyword(s):  
Plane Strain ◽  
Experimental Studies ◽  
Analytical Characterization

The results of the experimental studies on determination of the Muni—Rivlin coefficients arising under plane strain of reinforced polyurethane sample are described.

scholarly journals Multicomponent Materials to Improve Solubility: Eutectics of Drug Aminoglutethimide

2021 ◽  
Author(s):  
Basanta Saikia ◽  
Andreas Seidel-Morgenstern ◽  
Heike Lorenz
Keyword(s):  
Melting Point ◽  
Experimental Characterization ◽  
Analytical Characterization ◽  
X Ray ◽  
Eutectic Mixtures ◽  
Ft Ir ◽  
Aqueous Solubilities ◽  
Ft Ir Spectroscopy

Here, we report the synthesis and experimental characterization of three drug-drug eutectic mixtures of drug aminoglutethimide (AMG) with caffeine (CAF), nicotinamide (NIC) and ethenzamide (ZMD). The eutectic mixtures (AMG-CAF, AMG-NIC and AMG-ZMD) demonstrate significant melting point depressions ranging from 99.2 to 127.2 °C compared to the melting point of the drug AMG (151°C) and also show significantly higher aqueous solubilities than that of the AMG. The results presented include the determination of the binary melt phase diagrams and accompanying analytical characterization via X-ray powder diffraction, FT-IR spectroscopy and Scanning electron microscopy.

Sensitive UHPLC–MS/MS method for the determination of tacrolimus in minipig whole blood

Bioanalysis ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 519-532
Author(s):  
Manuel Álvarez ◽  
María Clotilde Hernández ◽  
Pere Macià ◽  
Josep Maria Jansat ◽  
Sonia Sentellas
Keyword(s):  
Whole Blood ◽  
Solid Phase ◽  
Topical Administration ◽  
Sample Treatment ◽  
Organ Rejection ◽  
Highly Sensitive ◽  
Interday Precision ◽  
Pharmacokinetic Behavior

Background: Tacrolimus, a potent immunosuppressant drug widely used systemically to reduce the risk of organ rejection in transplants, has been repositioned for topical treatment of atopic dermatitis. Results & methodology: This work describes the optimization of a new method for the determination of tacrolimus in whole blood after topical administration. Sample treatment consisted of an automated procedure based on protein precipitation followed by solid-phase extraction. The present method showed good performance with quantitation limits of 10 pg ml-1 and intra- and interday precision and accuracy lower than 15 and 10%, respectively. Conclusion: A new highly sensitive UHPLC–MS/MS method has been developed enabling a better characterization of the minipig blood plasma pharmacokinetic behavior of tacrolimus after topical administration.

Determination of the International Sensitivity Index of a New Near-Patient Testing Device to Monitor Oral Anticoagulant Therapy

1997 ◽  
Vol 78 (02) ◽  
pp. 855-858 ◽  
Author(s):  
Armando Tripodi ◽  
Veena Chantarangkul ◽  
Marigrazia Clerici ◽  
Barbara Negri ◽  
Pier Mannuccio Mannucci
Keyword(s):  
Linear Relationship ◽  
Whole Blood ◽  
Oral Anticoagulant ◽  
Oral Anticoagulant Therapy ◽  
Oral Anticoagulants ◽  
Calibration Model ◽  
Testing Device ◽  
Data Points ◽  
Near Patient Testing

SummaryA key issue for the reliable use of new devices for the laboratory control of oral anticoagulant therapy with the INR is their conformity to the calibration model. In the past, their adequacy has mostly been assessed empirically without reference to the calibration model and the use of International Reference Preparations (IRP) for thromboplastin. In this study we reviewed the requirements to be fulfilled and applied them to the calibration of a new near-patient testing device (TAS, Cardiovascular Diagnostics) which uses thromboplastin-containing test cards for determination of the INR. On each of 10 working days citrat- ed whole blood and plasma samples were obtained from 2 healthy subjects and 6 patients on oral anticoagulants. PT testing on whole blood and plasma was done with the TAS and parallel testing for plasma by the manual technique with the IRP CRM 149S. Conformity to the calibration model was judged satisfactory if the following requirements were met: (i) there was a linear relationship between paired log-PTs (TAS vs CRM 149S); (ii) the regression line drawn through patients data points, passed through those of normals; (iii) the precision of the calibration expressed as the CV of the slope was <3%. A good linear relationship was observed for calibration plots for plasma and whole blood (r = 0.98). Regression lines drawn through patients data points, passed through those of normals. The CVs of the slope were in both cases 2.2% and the ISIs were 0.965 and 1.000 for whole blood and plasma. In conclusion, our study shows that near-patient testing devices can be considered reliable tools to measure INR in patients on oral anticoagulants and provides guidelines for their evaluation.

Characterization of Impressed Current Technique to Model Corrosion of Reinforcement in Concrete

2020 ◽  
Vol 11 (1) ◽  
pp. 93-99
Author(s):  
Abu Zakir Morshed ◽  
Sheikh Shakib ◽  
Tanzim Jahin
Keyword(s):  
Immersion Time ◽  
Chloride Content ◽  
Engineering Science ◽  
Coastal Regions ◽  
Faraday’S Law ◽  
Current Technique ◽  
Corrosion Cell ◽  
Impressed Current

Corrosion of reinforcement is an important durability concern for the structures exposed to coastal regions. Since corrosion of reinforcement involves long periods of time, impressed current technique is usually used to accelerate the corrosion of reinforcement in laboratories. Characterization of impressed current technique was the main focus of this research,which involved determination of optimum chloride content and minimum immersion time of specimens for which the application of Faraday’s law could be efficient. To obtain optimum chloride content, the electrolytes in the corrosion cell were prepared similar to that of concrete pore solutions. Concrete prisms of 200 mm by 200 mm by 300 mm were used to determine the minimum immersion time for saturation. It was found that the optimum chloride content was 35 gm/L and the minimum immersion time for saturation was 140 hours. Accounting the results, a modified expression based on Faraday’s law was proposed to calculate weight loss due to corrosion. Journal of Engineering Science 11(1), 2020, 93-99

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