The positive effect of alloying elements on the thermal stability of the γ-matrix and the strengthening γ'-phase of casting nickel alloys, and consequently, on the increase in their heat-temperature strength is established. The alloying elements inhibit diffusion processes, thereby increasing the creep resistance of alloys at high temperatures and loads. It is found that the most indicative parameters of the phase composition of the test alloys are the alloying elements distribution coefficients between the γ- and γ'-phases. The basic principles of balanced alloying are formulated, on which the choice of the optimal chemical composition of heat-temperature nickel alloys is carried out.