COMBINATION OF EXTENDED DONOR CRITERIA AND DELTA-MELD SCORE PREDICT PATIENT SURVIVAL AND PRIMARY DYSFUNCTION IN LIVER TRANSPLANTATION.

2006 ◽  
Vol 82 (Suppl 2) ◽  
pp. 625
Author(s):  
&NA;
Keyword(s):  
Liver Transplantation ◽  
Patient Survival ◽  
Meld Score ◽  
Primary Dysfunction ◽  
Donor Criteria ◽  
Extended Donor Criteria

scholarly journals Liver Grafts with Major Extended Donor Criteria May Expand the Organ Pool for Patients with Hepatocellular Carcinoma

2019 ◽  
Vol 8 (10) ◽  
pp. 1692 ◽  
Author(s):  
Vladimir Lozanovski ◽  
Larissa Kerr ◽  
Elias Khajeh ◽  
Omid Ghamarnejad ◽  
Jan Pfeiffenberger ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Graft Survival ◽  
Patient Survival ◽  
Laboratory Model ◽  
Transplant Patients ◽  
One Year ◽  
End Stage ◽  
Donor Criteria ◽  
Extended Donor Criteria

The major extended donor criteria (maEDC; steatosis >40%, age >65 years, and cold ischemia time >14 h) influence graft and patient outcomes after liver transplantation. Despite organ shortages, maEDC organs are often considered unsuitable for transplantation. We investigated the outcomes of maEDC organ liver transplantation in patients with hepatocellular carcinoma (HCC). Two hundred and sixty-four HCC liver transplant patients were eligible for analysis. Risk factor analysis was performed for early allograft dysfunction; primary nonfunction; 30-day and 90-day graft failure; and 30-day, 90-day, and 1-year patient mortality. One-year graft survival was higher in recipients of no-maEDC grafts. One-year patient survival did not differ between the recipients of no-maEDC and maEDC organs. The univariate and multivariate analyses revealed no association between maEDC grafts and one-year patient mortality. Graft survival differed between the recipients of no-maEDC and maEDC organs after correcting for a laboratory model of end-stage liver disease (labMELD) score with a cut-off value of 20, but patient survival did not. Patient survival did not differ between recipients who did and did not meet the Milan criteria and who received grafts with and without maEDC. Instead of being discarded, maEDC grafts may expand the organ pool for patients with HCC without impairing patient survival or recurrence-free survival.

scholarly journals The impact of individual extended donor criteria on short- and long-term outcome after liver transplant in the MELD-score era

HPB ◽  
2019 ◽  
Vol 21 ◽  
pp. S1002
Author(s):  
V.J. Lozanovski ◽  
E. Khajeh ◽  
C.W. Michalski ◽  
H. Fonouni ◽  
R. von Haken ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Meld Score ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Short And Long Term ◽  
Donor Criteria ◽  
The Impact ◽  
Extended Donor Criteria

scholarly journals The impact of individual Extended Donor Criteria on short- and long-term outcome after liver transplant in the MELD-score era

HPB ◽  
2019 ◽  
Vol 21 ◽  
pp. S780
Author(s):  
V.J. Lozanovski ◽  
E. Khajeh ◽  
C.W. Michalski ◽  
H. Fonouni ◽  
R. von Haken ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Meld Score ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Short And Long Term ◽  
Donor Criteria ◽  
The Impact ◽  
Extended Donor Criteria

scholarly journals Utilization of extended donor criteria in liver transplantation: a comprehensive review of the literature

2007 ◽  
Vol 22 (Supplement 8) ◽  
pp. viii29-viii36 ◽  
Author(s):  
A. Nickkholgh ◽  
J. Weitz ◽  
J. Encke ◽  
P. Sauer ◽  
A. Mehrabi ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Review Of The Literature ◽  
Comprehensive Review ◽  
Donor Criteria ◽  
Extended Donor Criteria

scholarly journals Utilization of Extended Donor Criteria Liver Allografts Maximizes Donor Use and Patient Access to Liver Transplantation

2005 ◽  
Vol 123 (&NA;) ◽  
pp. 250-259 ◽  
Author(s):  
John F. Renz ◽  
Cindy Kin ◽  
Milan Kinkhabwala ◽  
Dominique Jan ◽  
Rhaghu Varadarajan ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Patient Access ◽  
Donor Criteria ◽  
Extended Donor Criteria

scholarly journals THE IMPACT OF THE MELD SCORE ON LIVER TRANSPLANT ALLOCATION AND RESULTS: AN INTEGRATIVE REVIEW

2017 ◽  
Vol 30 (1) ◽  
pp. 65-68 ◽  
Author(s):  
Ana Claudia Oliveira de MORAES ◽  
Priscilla Caroliny de OLIVEIRA ◽  
Olival Cirilo Lucena da FONSECA-NETO
Keyword(s):  
Liver Transplantation ◽  
Liver Disease ◽  
Liver Transplant ◽  
Alcoholic Cirrhosis ◽  
Meld Score ◽  
Terminal Phase ◽  
Post Surgery ◽  
End Stage ◽  
Donor Criteria ◽  
The Impact

ABSTRACT Introduction: Liver transplantation is intended to increase the survival of patients with chronic liver disease in terminal phase, as well as improved quality of life. Since the first transplant until today many changes have occurred in the organ allocation system. Objective: To review the literature on the Model for End-stage Liver Disease (MELD) and analyze its correlation with survival after liver transplantation. Method: An integrative literature review in Lilacs, SciELO, and Pubmed in October 2015, was realized. Were included eight studies related to the MELD score and its impact on liver transplant. Results: There was predominance of transplants in male between 45-55 y. The main indications were hepatitis C, hepatocellular carcinoma and alcoholic cirrhosis. The most important factors post-surgery were related to the MELD score, the recipient age, expanded donor criteria and hemotransfusion. Conclusion: The MELD system reduced the death rate in patients waiting for a liver transplant. However, this score by itself is not a good predictor of survival after liver transplantation.

scholarly journals Prioritization for liver transplantation

2020 ◽  
Vol 22 (3) ◽  
pp. 26-35
Author(s):  
V. L. Korobka ◽  
M. Y. Kostrykin ◽  
V. D. Passetchnikov ◽  
E. S. Pak
Keyword(s):  
Liver Transplantation ◽  
Serum Albumin ◽  
Odds Ratio ◽  
Patient Survival ◽  
Predictive Ability ◽  
Meld Score ◽  
Albumin Concentration ◽  
Characteristic Analysis ◽  
Predictive Values ◽  
Mortality Predictors

Objective: to determine the threshold MELD scores when prioritizing for liver transplantation. Materials and methods. We conducted a cohort study of 350 patients who were waitlisted for liver transplantation between 2015 and 2020. Results. A logistic regression model was used to identify the independent predictors of liver transplantation waitlist mortality. MELD scores and serum albumin at the time of listing were significant predictors of mortality (p = 0.001 and p = 0.004, respectively). Their predictive values were confirmed using ROC (Receiver Operating Characteristic) analysis. The area under the ROC curve (AUC) was 0.883 [95% confidence interval (CI) 0.828–0.939; p < 0.001] for MELD, and 0.841 [95% CI 0.775–0.907; p < 0.001] for serum albumin. Mortality odds ratio was 3.7778, 95% CI (1.619–7.765) provided that the listing MELD score was ≥25. Mortality odds ratio was 2.979 (95% CI 1.63–5.95) provided that the listing serum albumin concentration was ≤30.1 g/L. With a threshold MELD score of 25, there were significant differences between patient survival when comparing patient cohorts with MELD ≥25 and with MELD ≤25 (Log-rank, p < 0.0001). Conclusion. The MELD model has a high predictive ability in prioritization of waitlisted candidates for liver transplantation. The threshold MELD score and mortality predictors were determined. There were significant differences between patient survival among patient cohorts with MELD ≥25 and with MELD ≤25.

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