Inhibition of two stage renal carcinogenesis, oxidative damage and hyperproliferative response by Nigella sativa

2005 ◽  
Vol 14 (2) ◽  
pp. 159-168 ◽  
Author(s):  
N Khan ◽  
S Sultana
Keyword(s):  
Oxidative Damage ◽  
Nigella Sativa ◽  
Two Stage ◽  
Renal Carcinogenesis

Protective effect of Nigella sativa oil on cisplatin induced nephrotoxicity and oxidative damage in rat kidney

2017 ◽  
Vol 85 ◽  
pp. 7-15 ◽  
Author(s):  
Zeba Farooqui ◽  
Faizan Ahmed ◽  
Sana Rizwan ◽  
Faaiza Shahid ◽  
Aijaz Ahmed Khan ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Protective Effect ◽  
Nigella Sativa ◽  
Rat Kidney ◽  
Nigella Sativa Oil

Protection against radiation-induced oxidative damage by an ethanolic extract of Nigella sativa L.

2010 ◽  
Vol 86 (9) ◽  
pp. 719-731 ◽  
Author(s):  
Lori Rastogi ◽  
Shaikh Feroz ◽  
Badri Narain Pandey ◽  
Arti Jagtap ◽  
Kaushala Prasad Mishra
Keyword(s):  
Oxidative Damage ◽  
Nigella Sativa ◽  
Ethanolic Extract ◽  
Radiation Induced

Promoting Effect of Metal Compounds on Liver, Stomach, Kidney, Pancreas, and Skin Carcinogenesis

1989 ◽  
Vol 8 (7) ◽  
pp. 1235-1239 ◽  
Author(s):  
Y. Kurokawa ◽  
M. Takahashi ◽  
A. Maekawa ◽  
Y. Hayashi
Keyword(s):  
Skin Carcinogenesis ◽  
Promoting Effect ◽  
Two Stage ◽  
Metal Compounds ◽  
Renal Carcinogenesis ◽  
Stage Models

Systemic studies have been completed in Japan to detect those chemicals in the environment that act as promoters. Well-established two-stage models for liver, stomach, kidney, pancreas, and skin carcinogenesis were employed to detect the promoting effect of Zn Cl2, Cr Cl2, Cd Cl2, Ni Cl2, and Hg Cl2. As a result, Ni Cl2 was found to act as a promoter in renal carcinogenesis.

scholarly journals Specific Allelic Loss of p16INK4A Tumor Suppressor Gene after Weeks of Iron-Mediated Oxidative Damage during Rat Renal Carcinogenesis

2002 ◽  
Vol 160 (2) ◽  
pp. 419-424 ◽  
Author(s):  
Makoto Hiroyasu ◽  
Munetaka Ozeki ◽  
Haruyasu Kohda ◽  
Michiko Echizenya ◽  
Tomoyuki Tanaka ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Oxidative Damage ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Allelic Loss ◽  
Renal Carcinogenesis

scholarly journals Lack of Promoting Effect of Sodium Chlorate and Potassium Chlorate in Two-Stage Rat Renal Carcinogenesis

1985 ◽  
Vol 4 (6) ◽  
pp. 331-337 ◽  
Author(s):  
Y. Kurokawa ◽  
T. Imazawa ◽  
M. Matsushima ◽  
N. Takamura ◽  
Y. Hayashi
Keyword(s):  
Sodium Chlorate ◽  
Potassium Chlorate ◽  
Water Disinfection ◽  
Promoting Effect ◽  
Two Stage ◽  
Renal Carcinogenesis ◽  
Initiation Phase ◽  
The Mean ◽  
F344 Rats ◽  
Male F344 Rats

Sodium chlorate (NaClO3) and potassium chlorate (KClO3), which are byproducts of water disinfection with chlorine dioxide (ClO2), were tested for potential promoting effect in two-stage rat renal carcinogenesis. Three groups of 15 male F344 rats each were given N-ethyl-N-hydroxyethylnitrosamine (EHEN) at the level of 0.05% for the first 2 weeks during the initiation phase. Thereafter, the rats were treated orally for 25 weeks with NaClO3 (1%), KClO3 (1%), or distilled water (DW). Three other groups (controls) were treated similarly, except that DW was given in the initiation phase. All animals survived for the duration of the experiment. Renal neoplastic lesions were classified histologically as dysplastic foci (DF) and renal cell tumors (RCT). The number of these lesions per unit area, in six sections from each kidney, was determined microscopically. There were no statistically significant differences in the incidences and in the mean number of DF and RCT of the kidney between compound-and DW-treated rats initiated with EHEN. It is concluded that NaClO3 and KClO3 show no promoting effect in rat renal carcinogenesis under the conditions of this study.

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