Modulatory Effects of Shape Pluchea Lanceolata Against Chemically Induced Oxidative Damage, Hyperproliferation And Two-Stage Renal Carcinogenesis in Wistar Rats

2006 ◽  
Vol 291 (1-2) ◽  
pp. 175-185 ◽  
Author(s):  
Tamanna Jahangir ◽  
Sarwat Sultana
Keyword(s):  
Oxidative Damage ◽  
Wistar Rats ◽  
Two Stage ◽  
Renal Carcinogenesis ◽  
Pluchea Lanceolata ◽  
Chemically Induced

scholarly journals Modafinil Effects on Behavior and Oxidative Damage Parameters in Brain of Wistar Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Felipe Ornell ◽  
Samira S. Valvassori ◽  
Amanda V. Steckert ◽  
Pedro F. Deroza ◽  
Wilson R. Resende ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Open Field ◽  
Wistar Rats ◽  
Thiobarbituric Acid ◽  
Protein Carbonyl ◽  
Behavioral Changes ◽  
Protein Damage ◽  
Behavioral Parameters ◽  
Carbonyl Formation ◽  
The Brain

The effects of modafinil (MD) on behavioral and oxidative damage to protein and lipid in the brain of rats were evaluated. Wistar rats were given a single administration by gavage of water or MD (75, 150, or 300 mg/kg). Behavioral parameters were evaluated in open-field apparatus 1, 2, and 3 h after drug administration. Thiobarbituric acid reactive substances (TBARS) and protein carbonyl formation were measured in the brain. MD increased locomotor activity at the highest dose 1 and 3 h after administration. MD administration at the dose of 300 mg/kg increased visits to the center of open-field 1 h after administration; however, 3 h after administration, all administered doses of MD increased visits to the open-field center. MD 300 mg/kg increased lipid damage in the amygdala, hippocampus, and striatum. Besides, MD increased protein damage in the prefrontal cortex, amygdala, and hippocampus; however, this effect varies depending on the dose administered. In contrast, the administration of MD 75 and 300 mg/kg decreased the protein damage in the striatum. This study demonstrated that the MD administration induces behavioral changes, which was depending on the dose used. In addition, the effects of MD on oxidative damage parameters seemed to be in specific brain region and doses.

Chemically induced acute model of sarcosinemia in wistar rats

2015 ◽  
Vol 31 (2) ◽  
pp. 363-368 ◽  
Author(s):  
Rodrigo Binkowski de Andrade ◽  
Tanise Gemelli ◽  
Denise Bertin Rojas ◽  
Carlos Severo Dutra-Filho ◽  
Clovis Milton Duval Wannmacher
Keyword(s):  
Wistar Rats ◽  
Chemically Induced

Zingerone prevents lead‐induced toxicity in liver and kidney tissues by regulating the oxidative damage in Wistar rats

2020 ◽  
Author(s):  
Insha Amin ◽  
Ishraq Hussain ◽  
Muneeb U. Rehman ◽  
Bilal Ahmad Mir ◽  
Showkat Ahmad Ganaie ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Wistar Rats ◽  
Liver And Kidney
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