Pediatric dermatology 2003, innate immunity increases understanding of common skin disorders

2003 ◽  
Vol 15 (4) ◽  
pp. 398
Author(s):  
Richard L. Gallo
In Practice ◽  
2021 ◽  
Vol 43 (6) ◽  
pp. 318-327
Author(s):  
Alex Thiemann ◽  
Rebekah Sullivan
Keyword(s):  

1996 ◽  
Vol 98 (1) ◽  
pp. 178-179
Author(s):  
Timothy J. Mickel
Keyword(s):  

2010 ◽  
pp. 4593-4601
Author(s):  
Irene M. Leigh ◽  
David P. Kelsell

Most patients referred from primary care to the dermatology clinic will be seeking advice and treatment for a few common skin disorders, including psoriasis, eczema, and acne. The genetic basis of these complex conditions is being unravelled. For example, susceptibility variants have been identified in the gene for filaggrin (...


Author(s):  
Andrew Baldwin ◽  
Nina Hjelde ◽  
Charlotte Goumalatsou ◽  
Gil Myers

This chapter explores dermatology. It includes history and examination, creams and ointments, describing a lesion, patterns of skin disease, itch, skin signs in systemic disease, common skin cancers, malignant melanoma, moles, psoriasis, eczema (dermatitis), skin infections (fungi, bacteria, viruses), acne vulgaris, rosacea, drug eruptions, specific skin disorders (pemphigus and pemphigoid, strawberry naevus, pyogenic granuloma, lichen planus, pityriasis rosea, alopecia, photosensitivity, urticaria), venous ulcers, pressure sores, skin disorders and HIV, infestations, and psychodermatoses.


Cells ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 857 ◽  
Author(s):  
Manel Hammouda ◽  
Amy Ford ◽  
Yuan Liu ◽  
Jennifer Zhang

The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide range of cellular processes, including cell proliferation, differentiation, survival, apoptosis, and inflammation. Dysregulation of JNK pathway is associated with a wide range of immune disorders and cancer. Our objective is to provide a review of JNK proteins and their upstream regulators and downstream effector molecules in common skin disorders, including psoriasis, dermal fibrosis, scleroderma, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma.


Antibiotics ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 198 ◽  
Author(s):  
Olga Scudiero ◽  
Mariarita Brancaccio ◽  
Cristina Mennitti ◽  
Sonia Laneri ◽  
Barbara Lombardo ◽  
...  

Staphylococcus aureus is a microorganism capable of causing numerous diseases of the human skin. The incidence of S. aureus skin infections reflects the conflict between the host skin′s immune defenses and the S. aureus’ virulence elements. Antimicrobial peptides (AMPs) are small protein molecules involved in numerous biological activities, playing a very important role in the innate immunity. They constitute the defense of the host′s skin, which prevents harmful microorganisms from entering the epithelial barrier, including S. aureus. However, S. aureus uses ambiguous mechanisms against host defenses by promoting colonization and skin infections. Our review aims to provide a reference collection on host-pathogen interactions in skin disorders, including S. aureus infections and its resistance to methicillin (MRSA). In addition to these, we discuss the involvement of defensins and other innate immunity mediators (i.e., toll receptors, interleukin-1, and interleukin-17), involved in the defense of the host against the skin disorders caused by S. aureus, and then focus on the evasion mechanisms developed by the pathogenic microorganism under analysis. This review provides the “state of the art” on molecular mechanisms underlying S. aureus skin infection and the pharmacological potential of AMPs as a new therapeutic strategy, in order to define alternative directions in the fight against cutaneous disease.


1986 ◽  
Vol 20 (11) ◽  
pp. 876-880 ◽  
Author(s):  
Oscar E. Araujo ◽  
Debbie A. DeSantis ◽  
Paul L. Doering

A national survey of dermatologists and pharmacists was conducted to characterize the involvement of the community pharmacist in the area of skin diseases and to elicit suggestions to improve professional interrelations. The results show the dermatologists' major complaint is pharmacists' inability or unwillingness to compound prescriptions. The study clearly indicates the need for increased communication between the two professions in matters such as inventory control, prescription refill procedures, and substitution guidelines. The pharmacists, in general, admitted a deficiency in their educational preparedness to recognize common skin disorders, thus limiting their ability to assess the severity of patients' complaints.


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