Alterations in intestinal microflora, faecal bile acids and short chain fatty acids in dextran sulphate sodium-induced experimental acute colitis in rats

2001 ◽  
Vol 13 (2) ◽  
pp. 107-112 ◽  
Author(s):  
Yoshio Araki ◽  
Akira Andoh ◽  
Tomoyuki Tsujikawa ◽  
Yoshihide Fujiyama ◽  
Tadao Bamba
Keyword(s):  
Fatty Acids ◽  
Bile Acids ◽  
Intestinal Microflora ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Dextran Sulphate ◽  
Acute Colitis ◽  
Dextran Sulphate Sodium ◽  
Chain Fatty Acids

scholarly journals Development of Gut Microbiota Along with its Metabolites of Preschool Children

2021 ◽  
Author(s):  
Jingjing Xiong ◽  
Hongwei Hu ◽  
Chuanzhi Xu ◽  
Jianwen Yin ◽  
Mei Liu ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Preschool Children ◽  
Gut Microbiota ◽  
Bile Acids ◽  
Intestinal Microflora ◽  
Intestinal Flora ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Healthy Children ◽  
Chain Fatty Acids

Abstract Aim: To reveal the changes of intestinal microbial abundance and composition, as well as the microbiota metabolic levels of bile acids and short chain fatty acids of healthy preschool children during their growth. Methods: Feces of 120 healthy newborns and 150 healthy children aged 6 months to 6 years were collected. Then the composition of intestinal flora was analyzed by 16S rRNA, and the contents of bile acids and short chain fatty acids in feces were detected by LC-MS and GS methods, respectively. Results: The composition and function of intestinal microflora were not stable in neonatal period but significantly improved at 6 months after birth, and gradually stabilized and tended to adult-like formation after 2-3 years old. The levels of short chain fatty acids and secondary bile acids were consistent with the development of gut microbiota. Conclusion: The age of 6 months may be a critical period for the development of intestinal microflora in children.

scholarly journals Development of gut microbiota along with its metabolites of preschool children

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Jingjing Xiong ◽  
Hongwei Hu ◽  
Chuanzhi Xu ◽  
Jianwen Yin ◽  
Mei Liu ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Preschool Children ◽  
Gut Microbiota ◽  
Bile Acids ◽  
Intestinal Microflora ◽  
Intestinal Flora ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Healthy Children ◽  
Chain Fatty Acids

Abstract Background To reveal the changes of intestinal microbial abundance and composition, as well as the microbiota metabolic levels of bile acids and short chain fatty acids of healthy preschool children during their growth. Methods Feces of 120 healthy newborns and 150 healthy children aged 6 months to 6 years were collected. Then the composition of intestinal flora was analyzed by 16S rRNA, and the contents of bile acids and short chain fatty acids in feces were detected by LC-MS and GS methods, respectively. Results The composition and function of intestinal microflora were not stable in neonatal period but significantly improved at 6 months after birth, and gradually stabilized and tended to adult-like formation after 2–3 years old. The levels of short chain fatty acids and secondary bile acids were consistent with the development of gut microbiota. Conclusion The age of 6 months may be a critical period for the development of intestinal microflora in children.

Feeding Potato Flakes Affects Cecal Short-Chain Fatty Acids, Microflora and Fecal Bile Acids in Rats

2008 ◽  
Vol 52 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Kyu-Ho Han ◽  
Naoto Hayashi ◽  
Naoto Hashimoto ◽  
Ken-ichiro Shimada ◽  
Mitsuo Sekikawa ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Bile Acids ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Fecal Bile Acids ◽  
Potato Flakes ◽  
Chain Fatty Acids

scholarly journals Fecal Bile Acids and Fecal Short Chain Fatty Acids in Patients with Irritable Bowel Syndrome and Control Volunteers

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Chirag Patel ◽  
Carolyn Lockett ◽  
Huiping Xu ◽  
Andrea Shin
Keyword(s):  
Fatty Acids ◽  
Irritable Bowel Syndrome ◽  
Organic Acids ◽  
Bile Acids ◽  
Short Chain Fatty Acids ◽  
Small Sample ◽  
Short Chain ◽  
Fecal Bile Acids ◽  
Irritable Bowel ◽  
Chain Fatty Acids

Background and Aims: Fecal bile acids (BAs), short chain fatty acids (SCFAs), and gut microbiome may be implicated in irritable bowel syndrome (IBS) pathophysiology. Our aim was to compare fecal organic acids between IBS with constipation (IBS-C), IBS with diarrhea (IBS-D), and controls.   Methods: Stool samples were collected from 17 controls, 5 IBS-C, and 5 IBS-D volunteers during a 4-day high fat diet. Aliquots were stored for future analysis of the fecal microbiota. Fecal SCFA and BA analyses were conducted at the Metabolite Profiling Facility at Purdue University and Laboratory Medicine and Pathology at Mayo Clinic. We compared SCFA and BA levels among groups using the Wilcoxon rank sum test. Gamma and linear regression were used to compare SCFAs and BAs adjusting for age and body mass index (BMI).  Results: Fecal acetate levels (mean+SD, µg/mg) were higher in IBS-C (11.3±7) than in controls (6.1±3.3) or IBS-D (7.7±2), although not statistically significant (p=0.19). Total fecal BAs (median [IQR], %) were higher in IBS-D (675 [484-778]) than in controls (342 [130-640]) or IBS-C (321.5 (34.5-718); however, differences were not significant. No significant differences were observed in BAs or SCFAs between groups in multivariate analyses.  Conclusion: We are unable to show significant differences in organic acid levels in IBS and controls. Lack of association may be due to small sample size. Future investigation of larger patient numbers with incorporation of transit and microbiome analyses may shed further light on the role of organic acids in IBS to identify new biomarkers and treatment targets.

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