Self-Reported Diagnostic and Management Strategies in Childhood Idiopathic Thrombocytopenic Purpura: Results of a Survey of Practicing Pediatric Hematology/Oncology Specialists

2000 ◽  
Vol 22 (1) ◽  
pp. 55-61 ◽  
Author(s):  
Sara Vesely ◽  
George R. Buchanan ◽  
Alan Cohen ◽  
Gary Raskob ◽  
James George
Keyword(s):  
Idiopathic Thrombocytopenic Purpura ◽  
Management Strategies ◽  
Thrombocytopenic Purpura ◽  
Pediatric Hematology

scholarly journals EFFECT OF EDUCATIONAL PROGRAM ON NURSES’ PERFORMANCE FOR CHILDREN WITH IDIOPATHIC THROMBOCYTOPENIC PURPURA

2021 ◽  
Vol 13 (2) ◽  
Author(s):  
Sahar Wasfy ◽  
Rahma Soliman ◽  
Ebtisam El-Sayed ◽  
Basma Mahmoud
Keyword(s):  
Idiopathic Thrombocytopenic Purpura ◽  
Educational Program ◽  
Clinical Skills ◽  
Structured Interview ◽  
University Hospital ◽  
Basic Knowledge ◽  
Thrombocytopenic Purpura ◽  
Pediatric Hematology ◽  
Blood Disorder ◽  
Knowledge And Practice

Introduction: Idiopathic Thrombocytopenic Purpura is an autoimmune blood disorder associated with decrease platelets level less than normal, which may result in bleeding occurrence. The actual cause is unknown. It may be progressive if untreated, but may remit spontaneously for several years. The aim of this study was to evaluate the effect of health educational program on nurses’ performance for children with Idiopathic-Thrombocytopenic-Purpura. Methods: The study was Quasi- experimental research design used for 50 nurses working at Pediatric Hematology Unit of Tanta University Hospital and Pediatric Hematology Unit of Al- Mabra Tanta Hospital. Two Tools were used to collect required data: structured interview schedule to collect biosocial data of nurses and observational check list regarding nursing practice. Results: The present study-represented that, three quarter of nurses had poor-knowledge and all of them had unsatisfactory level of practice before the-educational-program-implementation. While immediately and after one month from the implementation of the program the total-scores-of-nurses' knowledge and practice improved. Conclusion: There was a-significant improvement in nursing knowledge and practice in relation to nursing care for children with Idiopathic-Thrombocytopenic-Purpura. Recommendations: In-service-training program should be conducted periodically for nurses' teaching the basic knowledge and clinical skills.

scholarly journals Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction in a Young Female with Idiopathic Thrombocytopenic Purpura: A Case Report and Review

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Ahmet Yildiz ◽  
Ugur Coskun ◽  
Ozlem Esen Batukan ◽  
Kudret Keskin
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Idiopathic Thrombocytopenic Purpura ◽  
Management Strategies ◽  
Coronary Intervention ◽  
Young Female ◽  
Anterior Myocardial Infarction ◽  
Thrombocytopenic Purpura ◽  
Percutaneous Coronary ◽  
Angioplasty And Stenting

A 23-year-old female with the diagnosis of idiopathic thrombocytopenic purpura (ITP) was admitted to our hospital with severe chest pain. The electrocardiogram (ECG) revealed acute anterior myocardial infarction. She underwent an immediate cardiac catheterization. An occluded left anterior descending (LAD) was detected by coronary angiography. Reperfusion was performed successfully by angioplasty and stenting with optimal distal flow without any complications. In this report we discussed the management strategies of acute myocardial infarction (AMI) in a patient with ITP.

Controversies in the Management of Acute Idiopathic Thrombocytopenic Purpura: A Survey of Specialists

PEDIATRICS ◽  
1986 ◽  
Vol 77 (1) ◽  
pp. 49-52
Author(s):  
A. Stephen Dubansky ◽  
Frank A. Oski
Keyword(s):  
Bone Marrow ◽  
Idiopathic Thrombocytopenic Purpura ◽  
Bone Marrow Examination ◽  
Thrombocytopenic Purpura ◽  
Pediatric Hematology ◽  
Do So

A total of 322 physicians, Board-certified in pediatric hematology, responded to a survey designed to determine several aspects of their management of children with acute idiopathic thrombocytopenic purpura. The survey demonstrates that, in practice among specialists, a controversy exists as to whether or not bone marrow examination needs to be performed, and how often corticosteroids should be prescribed. Seventy-four percent of practitioners would perform the bone marrow examination, whereas 26% would not do so. Forty-six percent of responders prescribe steroids more than half the time, whereas 54% prescribe steroids less than half the time. The questionnaire ascertained the reasons why physicians performed marrow aspirations and prescribed steroids.

scholarly journals Rescue therapy for acute idiopathic thrombocytopenic purpura unresponsive to conventional treatment

2019 ◽  
Vol 12 (1) ◽  
pp. bcr-2018-227717
Author(s):  
Samuel Benjamin Reynolds ◽  
Hamza Hashmi ◽  
Phuong Ngo ◽  
Goetz Kloecker
Keyword(s):  
Idiopathic Thrombocytopenic Purpura ◽  
Rescue Therapy ◽  
Management Strategies ◽  
B Cell Lymphoma ◽  
High Dose ◽  
Thrombocytopenic Purpura ◽  
High Dose Dexamethasone ◽  
Therapeutic Benefits ◽  
Conventional Medical Therapy

A 61-year-old woman with chronic lymphocytic leukaemia, with Richter’s transformation to a diffuse, large, B-cell lymphoma, treated with six cycles of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone and in complete remission, presented to the hospital after her platelets were found to be 2×10³/µL in outpatient laboratory studies. She initially underwent a platelet transfusion without improvement. This was followed by 4 days of high-dose dexamethasone and intravenous immunoglobulin, which again yielded no meaningful effect. Even a single-dose rituximab failed to achieve a platelet increase after 5 days of monitoring. The patient was then given 2 mg of intravenous vincristine along with a high-dose of dexamethasone and IVIG and demonstrated substantial recovery in platelets to >50×10³/µL within 48 hours. This case study provides an overview of the current management strategies for idiopathic thrombocytopenic purpura that is unresponsive to conventional medical therapy and particularly sheds light on their therapeutic benefits and potential adverse effects.

PAICA: A Method for Characterizing Platelet-Associated Antibodies - Its Application to the Study of Idiopathic Thrombocytopenic Purpura and to the Detection of Platelet-bound c7E3

1996 ◽  
Vol 76 (06) ◽  
pp. 1020-1029 ◽  
Author(s):  
Laurent Macchi ◽  
Gisèle Clofent-Sanchez ◽  
Gérald Marit ◽  
Claude Bihour ◽  
Catherine Durrieu-Jais ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Flow Cytometry ◽  
Idiopathic Thrombocytopenic Purpura ◽  
Antithrombotic Therapy ◽  
Membrane Glycoproteins ◽  
Serum Antibodies ◽  
Platelet Destruction ◽  
Thrombocytopenic Purpura ◽  
Capture Assay ◽  
Specific Membrane

SummaryIn idiopathic thrombocytopenic purpura (ITP), autoantibodies reacting with antigens on the platelet membrane bring about accelerated platelet destruction. We now report PAICA (“Platelet-Associated IgG Characterization Assay”), a method for detecting autoantibodies bound to specific membrane glycoproteins in total platelet lysates. This monoclonal antibody (MAb) capture assay takes into account the fact that antibodies on circulating platelets may be translocated to internal pools as well as being on the surface. A total of twenty ITP patients were examined by PAICA, and the results compared with those obtained by measuring (i) serum antibodies bound to paraformaldehyde-fixed control platelets by ELISA, (ii) IgG bound to the surface of the patient’s own platelets by flow cytometry (PSIgG), (iii) total platelet-associated IgG (PAIgG) by ELISA and (iv) serum antibodies reacting with control platelets by MAIPA (“Monoclonal Antibody-specific Immobilization of Platelet Antigens”). Of twelve patients with elevated PAIgG, nine had increased PSIgG yet eleven reacted positively in PAICA. Of these, eight possessed antibodies directed against GP Ilb-IIIa, two against GP Ib-IX and one patient possessed antibodies directed against GP Ilb-IIIa and GP Ia-IIa respectively. Only seven of the patients possessed serum antibodies detectable by MAIPA. PAICA was also able to detect platelet-associated c7E3 (the chimeric form of Fab fragments of the MAb 7E3) following its infusion during antithrombotic therapy, when it proved more sensitive over a seven-day period than a MAIPA assay adapted for assessing surface-bound antibody. We propose that PAICA provides added sensitivity to the detection of platelet-associated antibodies in immune thrombocytopenias or following therapy with humanized MAbs.

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