Awareness of breast cancer incidence and risk factors among healthy women

2004 ◽  
Vol 13 (4) ◽  
pp. 249-256 ◽  
Author(s):  
U G Pöhls ◽  
S P Renner ◽  
P A Fasching ◽  
M P Lux ◽  
H Kreis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Cancer Incidence ◽  
Breast Cancer Incidence ◽  
Healthy Women

Awareness of breast cancer incidence and risk factors among healthy women in Germany

2019 ◽  
Vol 28 (6) ◽  
pp. 515-521 ◽  
Author(s):  
Uwe G. Poehls ◽  
Carolin C. Hack ◽  
Marius Wunderle ◽  
Stefan P. Renner ◽  
Michael P. Lux ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Cancer Incidence ◽  
Breast Cancer Incidence ◽  
Healthy Women

scholarly journals Historical Trends in Incidence of Breast Cancer in Shanghai, Hong Kong and Los Angeles, 1973–2012: A Joinpoint and Age-Period-Cohort Analysis

2021 ◽  
Vol 66 ◽  
Author(s):  
Hang-Hang Luan ◽  
Li-Sha Luo ◽  
Zhi-Yan Lu
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Hong Kong ◽  
Los Angeles ◽  
Cancer Incidence ◽  
White Women ◽  
Cohort Analysis ◽  
Breast Cancer Incidence ◽  
Cohort Effects ◽  
Period Effect

Objectives: This study aimed to estimate the long-term trends of breast cancer incidence in Shanghai, Hong Kong, and Los Angeles (LA).Methods: Data were obtained from Cancer Incidence in Five Continents (CI5plus) database. The average annual percent change (AAPC) was conducted by joinpoint regression analysis, and the age, period and cohort effects were estimated by age-period-cohort (APC) analysis.Results: The age-standardized incidence rates (ASIRs) in LA were higher than Shanghai and Hong Kong. During 1988–2012, the ASIRs significantly decreased in white women in LA (AAPC = −0.6%, 95% CI: −0.9% to −0.4%) while increased in Shanghai (2.5%: 2.1%–2.9%) and Hong Kong (2.2%: 2.0%–2.5%). The APC analysis revealed significantly increased effects of age and period, and decreased effect of birth cohort.Conclusion: Although age and cohort effects were relatively strong, the period effect may be the key factor affecting trends of incidence, which may be caused by increasing exposures to carcinogens and risk factors. Therefore, more effective measures should be carried out promptly to protect high-risk populations such as elder women, to avoid exposures to risk factors of breast cancer.

scholarly journals Analisis Faktor Risiko Reproduksi yang Berhubungan dengan Kejadian Kanker Payudara pada Wanita

1970 ◽  
Vol 1 (2) ◽  
Author(s):  
Ardiana A ◽  
Hudayat Wijaya Negara ◽  
Ma'mun Sutisna
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
General Hospital ◽  
Cancer Incidence ◽  
Multivariate Analyses ◽  
Breast Cancer Incidence ◽  
Dominant Factor ◽  
Chi Square ◽  
Reproductive Risk ◽  
Reproductive Risk Factors

Kanker payudara paling banyak ditemui pada perempuan dan merupakan penyebab kematian kedua setelah kanker leher rahim.Penyebab kanker payudara tidak diketahui dengan jelas karena multifaktor. Bukti epidemiologi menunjukkan bahwa terdapat tiga faktor penyebab terjadinya kanker payudara yaitu faktor hormonal, faktor genetik dan faktor lingkungan. Provinsi Sumatera Utara menempati urutan kelima kejadian kanker payudara di antara seluruh provinsi yang ada di Indonesia. Tujuan penelitian ini adalah untuk menganalisis hubungan antara faktor risiko reproduksi dengan kejadian kanker payudara. Jenis penelitian ini adalah kasus kontrol dengan pendekatan retrospektif. Subjek penelitian adalah perempuan penderita kanker payudara yang mendapatkan perawatan dan pengobatan di Rumah Sakit Umum Pemerintah H.Adam Malik dan Rumah Sakit Umum Daerah dr.Pirngadi Medan. Jumlah sampel 100 responden yang terdiri dari 50 kasus dan 50 kontrol. Analisis yang digunakan adalah analisis bivariat menggunakan uji chi-square dan analisis multivariat menggunakan regresi logistik ganda. Hasil penelitian menunjukkan bahwa faktor risiko yang berhubungan dengan kejadian kanker payudara berdasarkan analisis bivariat adalah usia menarche (p=0.001), paritas (p=0.001), usia kehamilan pertama (p=0.001) dan menyusui (p=0.002). Pada analisis multivariat menunjukkan bahwa keempat faktor risiko yang diteliti secara statistik bermakna (p<0.05), yaitu usia menarche (OR=4,41;95%CI: 1,33 ̶14,63), paritas (OR=6,38;95%CI: 1,57–25,90), usia kehamilan pertama (OR=7,91;95%CI; 1,86−33,60) dan menyusui (OR=4,24;95%CI:1,22–14,76). Dapat disimpulkan bahwa faktor risiko reproduksi yang berhubungan dengan kejadian kanker payudara adalah usia menarche<12 tahun, paritas 1–2, usia kehamilan pertama 20–30 tahun dan tidak menyusui. Faktor risiko yang paling dominan dalam penelitian ini adalah usia kehamilan pertama.Kata kunci: Faktor risiko, kanker payudara, reproduksi AbstractBreast cancer is most commonly found in women, and is the second leading cause of death after cervical cancer. Due to its multifactorial nature, the cause of breast cancer is indeterminate. Epidemiological evidence suggests that there are 3 possible factors contributing to the occurrence of breast cancer, namely hormonal, genetic and environmental factors. North Sumatra is the 5th province having the highest breast cancer prevalence among all other provinces in Indonesia. The purpose of this study was to analyze various reproductive risk factors contributing to breast cancer incidence in women. The study was a retrospective case-control. Subjects were women with breast cancer who received care and treatment in H.Adam Malik General Hospital and dr.Pirngadi Medan General Hospital. The sample size was N=100 (n=50 – case group; n=50 – control group). The data were analyzed using bivariate analyses (Chi-square tests) and multivariate analyses (multiple logistic regressions). Bivariate analyses showed that reproductive risk factors associated with breast cancer were menarche period (p=0.001), parity (p=0.001), age of first pregnancy (p=0.001) and breastfeeding (p=0.002). Moreover, multivariate analyses showed statistically significant correlations (p <0.05) between the four reproductive risk factors and breast cancer incidence, including menarche period (OR=4.41, 95% CI: 1.33 ̶ 14.63), parity (OR=6.38, 95% CI : 1.57 ̶ 25.90), age of first pregnancy (OR=7.91, 95% CI: 1.86 to 33.60) and breastfeeding (OR= 4.24, 95% CI: 1.22 ̶ 14.76). In conclusion, the reproductive risks associated with breast cancer incidence in women were the menarche period of <12 years, parity of 1 ̶ 2 times, first pregnancy age of 20 ̶ 30 years old and non-breastfeeding status. In this study, the age of the first pregnancy was found to be the most dominant factor. Key words: Breast cancer, reproductive, risk factor

Physical activity and risk of postmenopausal breast cancer defined by hormone receptor status and histology: A large prospective cohort study with 18 years of follow up

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 1002-1002 ◽  
Author(s):  
A. Bardia ◽  
A. H. Wang ◽  
L. C. Hartmann ◽  
J. E. Olson ◽  
C. M. Vachon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Risk Factors ◽  
Cohort Study ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cancer Incidence ◽  
Breast Cancer Incidence ◽  
Histological Subtypes

1002 Background: Physical activity is a modifiable breast cancer risk factor, perhaps mediating risk reduction through regulation of estrogen metabolism. Evidence regarding effect of physical activity is conflicting partly because breast cancer is a heterogenous constellation of different tumor subtypes with differing etiologies. No prospective study has examined the relationship between physical activity and breast cancer incidence based on ER/PR status or histological subtype. Objective: Examine effect of physical activity on breast cancer incidence based on ER/PR status and histological subtypes of breast cancer. Methods: The Iowa Women’s Health Study is a prospective cohort study of postmenopausal women (N=41,837). Physical activity was self-reported on baseline questionnaire, and three levels (high, medium and low) were defined. Breast cancer incidence, histologic subtype and ER/PR status, through 18 years of follow-up, were ascertained by linkage with the Iowa SEER Cancer Registry. Cox proportional hazards models were used to estimate multivariate relative risks (RRs) and 95% confidence intervals (CIs) of breast cancer, adjusting for other breast cancer risk factors. Results: During 554,819 person-years of follow-up, 2548 incident cases of breast cancer were observed. High physical activity was associated with decreased risk for breast cancer (RR 0.91, 95 % CI 0.81–1.01) compared to low activity. The protective effect was most marked in ER+/PR− (RR 0.66, CI 0.46–0.94), intermediate in ER−/PR− (RR 0.80, CI 0.56–1.15), weakest in ER+/PR+ (RR 0.94, CI 0.81–1.08), and elevated in ER-/PR+ (RR 1.42, CI 0.67–3.01) tumors. Higher physical activity was also associated with a decreased risk of invasive ductal/lobular carcinoma (RR 0.90, CI 0.80–1.02), but not with invasive breast cancer with a favorable histology (RR 1.19, CI 0.78–1.81). Conclusions: Higher physical activity was associated with a 10% decreased risk of breast cancer. Unexpectedly, risk reduction was most marked in PR- tumors, particularly ER+/PR-, and the more aggressive histologic forms. Further studies are needed to confirm these findings, and also evaluate other risk factors based on ER/PR status and histological subtypes. No significant financial relationships to disclose.

BMI change and abdominal girth as risk factors of breast cancer.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e13082-e13082
Author(s):  
Yusuke Suzuki ◽  
Hiroko Tsunoda ◽  
Takeshi Kimura ◽  
Hideko Yamauchi
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Cancer Screening ◽  
Postmenopausal Women ◽  
Cancer Incidence ◽  
Breast Cancer Incidence ◽  
Develop Breast Cancer ◽  
Asian Women ◽  
Abdominal Girth ◽  
High Hba1c

e13082 Background: While obesity is considered the risk factors of breast cancer, Asian women are tends to be lower BMI compared with Western populations and there are not much reports that studied association between obesity and risk of breast cancer in Asian women. In this study, we analyzed the associations of breast cancer incidence and body mass index at age 18-20 (BMI 18-20y), BMI at research entry (BMI at entry), change of the BMI from BMI 18-20y to BMI at entry (BMI change), abdominal girth at research entry (AG), HbA1c [N] at research entry (HbA1c). Methods: We used data of the women who had undergone medical check-ups and opportunistic breast cancer screening at least twice at the Center for Preventive Medicine of St. Luke’s International Hospital between April 1, 2005 and March 31, 2014. Statistical analysis was done by using multivariate Cox proportional hazards model to investigate the hazard ratio (HR) at 95% confidence intervals (95% CI). Results: In this 10 year period, 30,109 women (20,043 women were premenopausal and 10,066 women were postmenopausal women) received opportunistic breast cancer screening at least twice. After analysis of 131656.6 person-years follow up during 10 years, 325 initial breast cancer cases were identified 202 cases in premenopausal women, and 123 cases in postmenopausal women. Among postmenopausal women, BMI change and AG were positively associated with breast cancer incidence. Women whose BMI change were major gain group (> +5.0) were significantly likely to develop breast cancer compared with stable group (BMI change were between -2.5 to +2.5) [HR: 1.902 (95% CI = 1.202-3.009)]. Large AG ( > 90cm) was significant risk to develop breast cancer versus less than 70cm [HR: 2.500 (95% CI = 1.091-5.730)]. In the analysis classified BMI18-20y more and less than 20 kg/m2, large BMI18-20y ( > 20 kg/m2) postmenopausal women with high HbA1c ( > 6.5) was more likely to develop breast cancer compared with low HbA1c ( < 5.5) [HR: 3.325(95% CI = 1.307-8.460)]. Conclusions: Increase of BMI after age of 18-20 years and large AG in postmenopausal women have positive association with breast cancer development. High HbA1c women whose BMI18-20y was over 20 kg/m2 are significantly to develop breast cancer.

Risk-based recommendations for mammographic screening for women in their forties.

1998 ◽  
Vol 16 (9) ◽  
pp. 3105-3114 ◽  
Author(s):  
M Gail ◽  
B Rimer
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Black Women ◽  
Cancer Incidence ◽  
White Women ◽  
Present Report ◽  
Breast Cancer Incidence ◽  
Mammographic Screening ◽  
Incidence Rates ◽  
Flow Diagram

PURPOSE To develop risk-based recommendations for mammographic screening for women in their 40s that take into account the woman's age, race, and specific risk factors. METHODS We assumed that regular mammographic screening is justified for a 50-year-old woman, even one with no risk factors, and that a younger woman with an expected 1-year breast cancer incidence rate as great or greater than that of a 50-year-old woman with no risk factors would benefit sufficiently to justify regular screening. Recommendations under this criterion were based on age- and race-specific breast cancer incidence rates from the National Cancer Institute's (NCI's) Surveillance, Epidemiology, and End Results (SEER) Program; assessments of risk factors from the Breast Cancer Detection and Demonstration Project (BCDDP); and reports in the literature. RESULTS Two methods, the exact-age procedure (EAP) and the grouped-age procedure (GAP), were developed. The less precise GAP only requires following a flow diagram. The proportion of white women recommended for screening by the EAP ranges from 10% for 40-year-old women to 95% for 49-year-old women, and the corresponding percentages for black women are 16% and 95%. The assumptions that underlie the guidelines are discussed critically. CONCLUSION For women or physicians who prefer an individualized approach in deciding whether to initiate regular mammographic screening in the age range of 40 to 49 years, the present report offers recommendations based on individualized risk-factor data and clearly stated assumptions that have an empiric basis. These recommendations can be used to facilitate the counseling process.

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