CO24. Seasonal variations in vitamin D levels in melanoma patients

SummaryThe prevalence of both vitamin D deficiency and venous thromboembolism (VTE) is important in the elderly. Previous studies have provided evidence for a possible association between vitamin D status and the risk of VTE. Thus, we aimed to investigate the association between vitamin D levels and VTE in the population aged 75 and over included in the EDITH case-control study. The association between vitamin D status and VTE was analysed. We also analysed the monthly and seasonal variations of VTE and vitamin D. Between May 2000 and December 2009, 340 elderly patients (mean age 81.5 years, 32 % men) with unprovoked VTE and their controls were included. The univariate and multivariate analysis found no significant association between serum levels of vitamin D and the risk of unprovoked VTE. In the unadjusted analysis, a higher BMI was statistically associated with an increased risk of VTE (OR 1.09; 95 % CI 1.05–1.13) whereas a better walking capacity and living at home were associated with a decreased rate of VTE: OR 0.57; 95 % CI 0.36–0.90 and 0.40; 95 % CI 0.25–0.66, respectively. Although not significant, more VTE events occurred during winter (p=0.09). No seasonal variations of vitamin D levels were found (p=0.11). In conclusion, in contrast with previous reports our findings suggest that vitamin D is not associated with VTE in the elderly population.

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Older women do not have seasonal variations of vitamin D levels

Menopause The Journal of The North American Menopause Society ◽

10.1097/gme.0000000000001103 ◽

2018 ◽

Vol 25 (8) ◽

pp. 912-917 ◽

Cited By ~ 2

Author(s):

María S. Vallejo ◽

Juan E. Blümel ◽

Pablo Lavín ◽

Claudio Torres ◽

Alejandro Araos ◽

...

Keyword(s):

Vitamin D ◽

Older Women ◽

Seasonal Variations ◽

Vitamin D Levels

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Serum vitamin D levels, VDR, and survival from melanoma

Journal of Clinical Oncology ◽

10.1200/jco.2009.27.15_suppl.9016 ◽

2009 ◽

Vol 27 (15_suppl) ◽

pp. 9016-9016

Author(s):

J. A. Newton Bishop ◽

S. Beswick ◽

J. Randerson-Moor ◽

Y. Chang ◽

P. Affleck ◽

...

Keyword(s):

Vitamin D ◽

Cohort Study ◽

Pilot Study ◽

Serum Vitamin ◽

Breslow Thickness ◽

Dihydroxyvitamin D3 ◽

Vitamin D Levels ◽

Study Results ◽

Melanoma Patients ◽

Risk Of Relapse

9016 Background: Vitamin D has pleiotropic effects, which may moderate the interaction between patients and their tumors. Two studies were carried out to test the hypothesis that higher vitamin D levels reduce the risk of relapse from melanoma. Methods: A pilot retrospective case-control study in 271 melanoma patients suggested that vitamin D may protect against recurrence of melanoma. We then tested these findings in a survival analysis in a cohort of 872 cases recruited to the Leeds Melanoma Cohort (median follow up of 4.7 years). Results: Pilot study Results suggested that taking vitamin D reduced the risk of relapse from melanoma (OR 0.6, 95% CI: 0.4, 1.1). Non-relapsers had higher mean 25-dihydroxyvitamin D3 levels than relapsers (49 nmol/L compared with 46, p=0.3). Cohort study Higher 25-dihydroxyvitamin D3 levels were associated with lower Breslow thickness at diagnosis and were independently protective of relapse and death: hazard ratio (HR) for relapse free survival (RFS) 0.76, 95% CI: (0.64, 0.96), for a 20nmol/L increase in serum level. There was evidence of interaction between the vitamin D receptor (VDR) BsmI genotype and serum 25-dihydroxyvitamin D3 levels on RFS. Conclusions: The pilot study provided preliminary evidence for a role for vitamin D in outcome from melanoma. The cohort study provided further evidence that higher 25-dihydroxyvitamin D3 levels, at diagnosis, were associated both with thinner tumors and better survival, independent of Breslow thickness, from melanoma. Melanoma patients should avoid vitamin D deficiency. Further studies are needed to establish optimal serum levels for melanoma patients. No significant financial relationships to disclose.

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Seasonal variations in vitamin D levels in HIV-infected patients

HIV & AIDS Review ◽

10.5114/hivar.2017.65397 ◽

2017 ◽

Vol 1 ◽

pp. 50-53

Author(s):

Sebastian Noe ◽

Silke Heldwein ◽

Rita Pascucci ◽

Celia Oldenbüttel ◽

Carmen Wiese ◽

...

Keyword(s):

Vitamin D ◽

Seasonal Variations ◽

Vitamin D Levels

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878 Optimizing Follow Up for Melanoma Patients: Are We Meeting NICE Guidance?

British Journal of Surgery ◽

10.1093/bjs/znab259.107 ◽

2021 ◽

Vol 108 (Supplement_6) ◽

Author(s):

A Labib ◽

C Massardi ◽

L Salfity ◽

B Powell

Keyword(s):

Vitamin D ◽

University Hospitals ◽

Tertiary Referral Centre ◽

Qualitative Survey ◽

Skin Cancers ◽

Vitamin D Levels ◽

Nice Guidance ◽

Melanoma Patients

Abstract Introduction St. George’s University Hospitals NHS Foundation Trust is a designated tertiary referral Centre for all skin cancers serving a population of 3.5 million in and around South West London. It has an international reputation for its management of melanoma cases. All melanoma patients need frequent follow up visits for a long period of time which may extend to more than 10 years. Many aspects should be included when following up these patients including clinical assessment, laboratory, and radiological evaluation. Aim The aim of this project is to assess the quality of laboratory follow up of melanoma patients focusing on optimizing vitamin D level. Method We performed a retrospective review of cutaneous melanoma patients in 2019. Laboratory standards for follow up of vitamin D level was identified from NICE guidance 2015. After introduction of a condensed guide, a second review was performed in 2020. Results In the first cycle, 63 patients were included. Only 47% of them had their Vitamin D levels checked at time of diagnosis. Follow up check for vitamin D level was only done in 36%. Following introduction of guidance, 36 patients have been included. Significant improvement in both parameters with rate of 65% and 96% respectively. Conclusions Although we managed to improve our adherence to NICE guidance, more effort is still needed to improve all patients' care. We are willing to conduct a qualitative survey asking staff to explore their obstacles.

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Reply to: The effect of seasonal variations on vitamin D levels in pregnant women

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-015-3716-z ◽

2015 ◽

Vol 292 (1) ◽

pp. 3-4

Author(s):

Rimpi Singla

Keyword(s):

Vitamin D ◽

Pregnant Women ◽

Seasonal Variations ◽

Vitamin D Levels

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Seasonal variations in serum 25-hydroxy vitamin D levels in a Swedish cohort

Endocrine ◽

10.1007/s12020-015-0548-3 ◽

2015 ◽

Vol 49 (3) ◽

pp. 800-808 ◽

Cited By ~ 70

Author(s):

Eva Klingberg ◽

Göran Oleröd ◽

Jan Konar ◽

Max Petzold ◽

Ola Hammarsten

Keyword(s):

Vitamin D ◽

Seasonal Variations ◽

Vitamin D Levels ◽

25 Hydroxy Vitamin D ◽

Swedish Cohort

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The unpredictability of seasonal variations in serum vitamin D levels in children with asthma and/or rhinitis

Allergologia et Immunopathologia ◽

10.1016/j.aller.2019.01.002 ◽

2019 ◽

Vol 47 (5) ◽

pp. 411-416 ◽

Cited By ~ 1

Author(s):

S. Miceli Sopo ◽

G. Cerchiara ◽

G. Bersani ◽

S. Monaco ◽

A. Romano ◽

...

Keyword(s):

Vitamin D ◽

Seasonal Variations ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Children With Asthma

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Seasonal variations of 25-OH vitamin D serum levels in Multiple Sclerosis patients with relapse using MRI

European Journal of Translational Myology ◽

10.4081/ejtm.2019.8361 ◽

2019 ◽

Vol 29 (3) ◽

Author(s):

Sharareh Sanei Sistani ◽

Ali Moghtaderi ◽

Ali Reza Dashipoor ◽

Maryam Ghaffarpoor ◽

Bahareh Heshmat Ghahderijani

Keyword(s):

Multiple Sclerosis ◽

Spinal Cord ◽

Vitamin D ◽

Seasonal Variations ◽

Significant Relationship ◽

Cervical Spinal Cord ◽

Serum Vitamin ◽

Serum Levels ◽

Serum Vitamin D ◽

Vitamin D Levels

An increasing body of evidence suggests that low vitamin D (25-[OH]-D) concentrations is linked to increased activity in multiple sclerosis (MS) patients and MS relapse. Therefore, the current study was aimed to evaluate vitamin D serum concentrations and its possible seasonal variations among MS patients with relapse. This prospective, descriptive study was conducted on patients with MS relapse who referred to the neurology center of Ali ibn Abi Talib Hospital in Zahedan during one year. Magnetic Resonance Imaging (MRI)-Spine was performed for 90 patients and serum samples were collected from patient to measure serum vitamin D levels using RIA KIT. Furthermore, the plaques in each patient's MRI were counted and then recorded. Descriptive and inductive statistics were conducted using statistical software. Our findings indicated a significant correlation between serum vitamin D level and cervical spinal cord plaques (p = 0.007, r = 0.28), while no association was revealed between serum vitamin D level and number of brain plaque. Furthermore, a significant association was also observed between number of cervical spinal cord plaques and serum vitamin D levels. In addition, a reverse correlation was observed between number of cervical spinal cord plaques and serum vitamin D levels in spring. In autumn, there was a statistically significant relationship between number of brain plaque and serum vitamin D level. Additionally, a statistically significant relationship was found between serum vitamin D levels and number of plaques in winter. Our findings are in agreement with some previous studies that reported conflicting result, where the association of season with the prevalence of relapse cases cannot be verified. Although the mean serum levels of vitamin D are inversely correlated with the incidence of relapses in winter. However, the values obtained in the spring do not confirm such an inverse relationship.

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