In pediatric patients on antibiotic therapy, do probiotics prevent antibiotic-associated diarrhea?

2017 ◽  
Vol 20 (7) ◽  
pp. E8-E9
Author(s):  
Ehab Molokhia ◽  
Amy Kayl ◽  
Huy Lam ◽  
Ashlen Aggen ◽  
Brandi Robinson
Keyword(s):  
Antibiotic Therapy ◽  
Pediatric Patients ◽  
Antibiotic Associated Diarrhea

scholarly journals Antibiotic-associated diarrhea in children: how to identify, what to do and how to treat?

2016 ◽  
Vol 1 (1) ◽  
pp. 78-89
Author(s):  
I. N. Zakharova ◽  
I. V. Berezhnaya ◽  
E. B. Mumladze
Keyword(s):  
High Risk ◽  
Antibiotic Therapy ◽  
Intestinal Microbiota ◽  
High Probability ◽  
Pseudomembranous Colitis ◽  
Inflammatory Diseases ◽  
Pediatric Practice ◽  
Antibiotic Associated Diarrhea ◽  
New Generation ◽  
Very High

Rational antibiotic therapy is one of the most important components in the treatment of children with various infectious and inflammatory diseases. However, wide and sometimes unjustified use of AB in pediatric practice often leads to the development of a variety of complications. Children receiveing AB, especially during the first 5 years of life, are at a very high risk of developing antibiotic-associated diarrhea (AAD) which manifests itself in three or more episodes of unformed stools for two or more consecutive days or for 8 weeks after withdrawal. The most relevant pathogen of AAD is C. difficile which, according to various data, causes from 10 to 25% of AAD cases and 90 to 100% of all cases of pseudomembranous colitis (PMC). Given the high probability of developing dangerous complications such as PMC, special attention should be paid to the prevention of the infection associated with C. difficile by reducing the frequency of uncontrolled and unjustified use of AB. A new generation of eco-antibiotics can be recommended which allow to maintain diversity of the intestinal microbiota and are less likely to cause complications.

scholarly journals Clinical and microbial characterization of toxigenic Clostridium difficile isolated from antibiotic associated diarrhea in Egypt

2020 ◽  
Author(s):  
Sherein G. Elgendy ◽  
Sherine A. Aly ◽  
Rawhia Fathy ◽  
Enas A.E. Deaf ◽  
Naglaa H. Abu Faddan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Clostridium Difficile ◽  
Pediatric Patients ◽  
Direct Detection ◽  
Diagnostic Methods ◽  
Adult Patients ◽  
Specific Method ◽  
Healthcare Associated Infection ◽  
Direct Pcr ◽  
Antibiotic Associated Diarrhea

Background and Objectives: Clostridium difficile infection (CDI) has become a significant healthcare-associated infection throughout the world and is particularly important in developing countries. This study aimed to investigate clinical characterization and risk factors related to toxigenic C. difficile infection in adult and pediatric patients, antimicrobial susceptibility pattern. Also, to evaluate different diagnostic methods for rapid detection of C. difficile associated diarrhea (CDAD) in Egypt. Materials and Methods: Stool samples were collected from 95 pediatric patients and 37 adult patients suffering from antibiotic associated diarrhea and were subjected to direct toxin immunoassay and culture on cycloserine/cefoxitin/fructose agar. The presence of tcdA and tcdB genes was tested by PCR. Results: Toxigenic C. difficile was isolated from pediatric and adult patients at a rate of 17.89% (17/95) and 27% (10/37) respectively. The sensitivity and specificity of direct PCR from stool are (100%, 100% and 82.4%, 100%) in adult and pediatric samples respectively. The susceptibility of C. difficile to vancomycin and metronidazole were found to be 66.7% and 48.2% respectively. Conclusion: Diabetes mellitus, prior antibiotic treatment, hematological malignancy on chemotherapy, malnutrition, neutropenia and Ryle feeding are risk factors for development of CDAD. Tight restriction of unnecessary antibiotic uses is necessary in our locality. Direct detection of toxin genes in stool by PCR is sensitive and specific method for early detection of C. difficile.

Frequency of Antibiotic-Associated Diarrhea and Related Complications in Pediatric Patients Who Underwent Hypospadias Repair: a Comparative Study Using Probiotics vs Placebo

2017 ◽  
Vol 10 (2) ◽  
pp. 323-328 ◽  
Author(s):  
Ciro Esposito ◽  
Agnese Roberti ◽  
Francesco Turrà ◽  
Mariapina Cerulo ◽  
Giovanni Severino ◽  
...  
Keyword(s):  
Comparative Study ◽  
Pediatric Patients ◽  
Hypospadias Repair ◽  
Antibiotic Associated Diarrhea

Intravenous antibiotic therapy in ambulatory pediatric patients

1984 ◽  
Vol 3 (6) ◽  
pp. 514-517 ◽  
Author(s):  
ROBIN I. GOLDENBERG ◽  
DONALD M. PORETZ ◽  
LAWRENCE J. ERON ◽  
JAMES B. RISING ◽  
SARAH B. SPARKS
Keyword(s):  
Antibiotic Therapy ◽  
Pediatric Patients ◽  
Intravenous Antibiotic ◽  
Intravenous Antibiotic Therapy

Ertapenem versus Standard Triple Antibiotic Therapy for the Treatment of Perforated Appendicitis in Pediatric Patients: A Prospective Randomized Trial

2013 ◽  
Vol 24 (05) ◽  
pp. 410-418
Author(s):  
Cetin Karadag ◽  
Banu Bayraktar ◽  
Mesut Sancar ◽  
Ozlem Kara ◽  
Suleyman Pelit ◽  
...  
Keyword(s):  
Antibiotic Therapy ◽  
Randomized Trial ◽  
Pediatric Patients ◽  
Perforated Appendicitis ◽  
Prospective Randomized Trial

scholarly journals THE RATIONALITY OF ANTIBIOTICS THERAPY TOWARD CHILDREN WITH TYPHOID FEVER AT M.M. DUNDA HOSPITAL

2018 ◽  
Vol 11 (7) ◽  
pp. 185
Author(s):  
Teti Sutriyati Tuloli ◽  
Dewi R Moo
Keyword(s):  
Infectious Disease ◽  
Small Intestine ◽  
Antibiotic Therapy ◽  
Typhoid Fever ◽  
Medical Records ◽  
Pediatric Patients ◽  
Data Retrieval ◽  
Salmonella Typhi ◽  
Retrospective Data ◽  
Impaired Consciousness

Objectives: Typhoid fever is an acute systemic infectious disease in the small intestine caused by Salmonella enterica serotype typhi (Salmonella typhi) having the symptoms of fever a week or more with impairment of the gastrointestinal tract with or without impaired consciousness. The purpose of this study was to determine the rationality of antibiotic therapy in pediatric patients at M.M Dunda Limboto Hospital.Methods: This research belongs to non-experimental descriptive with retrospective data retrieval. The data used were obtained from 83 medical records of childhood typhoid patients during 6 months (June–November 2016) at the regional general hospital of M.M Dunda Limboto. These data were analyzed using the Gyssens criteria.Results: The results showed that the most antibiotics used by physicians were ceftriaxone 39% of the use of antibiotic quality which was category IIB 9%, category IIA 13%, and category 0 (rational) 52%.Conclusion: The rationality of antibiotic therapy in children with typhoid fever at M.M Dunda Limboto Hospital was 52% of the most antibiotics used, i.e. ceftriaxone (39%). 

scholarly journals Hafnia alvei causing late onset sepsis in neonates: report of two cases and review of literature

2018 ◽  
Vol 5 (2) ◽  
pp. 673
Author(s):  
Laxman Basani ◽  
Roja Aepala
Keyword(s):  
Antibiotic Therapy ◽  
Pediatric Patients ◽  
Neonatal Period ◽  
Late Onset ◽  
Review Of Literature ◽  
Term Neonates ◽  
Gram Negative ◽  
Hafnia Alvei ◽  
Late Onset Sepsis ◽  
Compromised Patients

Hafnia alvei, a Gram negative motile bacillus that belongs to Enterobacteriaceae family is rarely associated with infection in pediatric patients and is exceptionally rare in the neonatal period. H. alvei is ubiquitous in the environment, causing infections in debilitated and immuno-compromised patients with few cases being reported in neonates. We report two cases of late onset sepsis in term neonates caused by H. alvei that were successfully treated in our unit. To the best of our knowledge, infection due to H. alvei has not been reported in neonates from India. Hafnia alvei causes infection rarely in neonates. Because it can cause nosocomial outbreaks, awareness regarding this uncommon pathogen and initiation of appropriate antibiotic therapy improves the outcome and prevents mortality.

Sign in / Sign up

Export Citation Format

Share Document