244 PATERNAL FAMILY HISTORY OF HIGH BLOOD PRESSURE IS ASSOCIATED WITH AN INCREASED RISK FOR HAVING HIGH BLOOD PRESSURE IN MEN

2012 ◽  
Vol 30 ◽  
pp. e74
Author(s):  
Christine L Chiu ◽  
Sanja Lujic ◽  
Joanne M Lind
Keyword(s):  
Blood Pressure ◽  
Family History ◽  
High Blood Pressure ◽  
Increased Risk ◽  
History Of

scholarly journals Knowledge, attitudes and practices of West Africans on genetic studies of stroke: Evidence from the SIREN Study

2018 ◽  
Vol 14 (1) ◽  
pp. 69-79 ◽  
Author(s):  
Rufus O Akinyemi ◽  
Fred S Sarfo ◽  
Joshua Akinyemi ◽  
Arti Singh ◽  
Matthew Onoja Akpa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Genetic Testing ◽  
Family History ◽  
High Blood Pressure ◽  
Stroke Patients ◽  
Genetic Studies ◽  
Attitudes And Practices ◽  
Heritable Disorder ◽  
History Of ◽  
Knowledge Attitudes And Practices

Background It is crucial to assess genomic literacy related to stroke among Africans in preparation for the ethical, legal and societal implications of the genetic revolution which has begun in Africa. Objective To assess the knowledge, attitudes and practices (KAP) of West Africans about stroke genetic studies. Methods A comparative cross-sectional study was conducted among stroke patients and stroke-free controls recruited across 15 sites in Ghana and Nigeria. Participants' knowledge of heritability of stroke, willingness to undergo genetic testing and perception of the potential benefits of stroke genetic research were assessed using interviewer-administered questionnaire. Descriptive, frequency distribution and multiple regression analyses were performed. Results Only 49% of 2029 stroke patients and 57% of 2603 stroke-free individuals knew that stroke was a heritable disorder. Among those who knew, 90% were willing to undergo genetic testing. Knowledge of stroke heritability was associated with having at least post-secondary education (OR 1.51, 1.25–1.81) and a family history of stroke (OR 1.20, 1.03–1.39) while Islamic religion (OR=0.82, CI: 0.72–0.94), being currently unmarried (OR = 0.81, CI: 0.70–0.92), and alcohol use (OR = 0.78, CI: 0.67–0.91) were associated with lower odds of awareness of stroke as a heritable disorder. Willingness to undergo genetic testing for stroke was associated with having a family history of stroke (OR 1.34, 1.03–1.74) but inversely associated with a medical history of high blood pressure (OR = 0.79, 0.65–0.96). Conclusion To further improve knowledge of stroke heritability and willingness to embrace genetic testing for stroke, individuals with less formal education, history of high blood pressure and no family history of stroke require targeted interventions.

Increased Erythrocyte Lithium-Sodium Countertransport in Essential Hypertension: Its Relationship to Family History of Hypertension

1981 ◽  
Vol 61 (s7) ◽  
pp. 13s-15s ◽  
Author(s):  
M. Canali ◽  
L. Borghi ◽  
E. Sani ◽  
A. Curti ◽  
A. Montanari ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Family History ◽  
High Blood Pressure ◽  
Degree Relative ◽  
Mean Values ◽  
The Family ◽  
History Of ◽  
Family History Of Hypertension ◽  
And Control

1. Erythrocyte lithium—sodium counter-transport was measured in 46 normotensive healthy controls without family history of hypertension, 15 subjects with essential hypertension, but without evidence of family history of high blood pressure, and 43 subjects with essential hypertension and at least one hypertensive first-degree relative. 2. Mean values (mmol h−1 l−1 of erythrocytes) were 0.248 ± 0.092 in controls, 0.258 ± 0.087 in hypertensive subjects without family history (not significant vs controls), 0.360 ± 0.115 in hypertensive subjects with family history of hypertension (P < 0.001 vs controls), 0.334 ± 0.117 in all hypertensive subjects, both with and without family history (P < 0.001 vs controls). 3. Our data confirm the finding of an increased erythrocyte lithium-sodium counter-transport, but with a significant overlap between essential hypertension and control values. Lithium-sodium countertransport is higher only in hypertensive subjects with at least one hypertensive first-degree relative. 4. We suggest that the increase of lithium-sodium countertransport in erythrocytes is not a consistent marker of essential hypertension. It seems to be associated with the family prevalence and/or the hereditability of hypertension, rather than with high blood pressure per se.

scholarly journals REPEATED HIGH BLOOD PRESSURE AT 6 AND 11 YEARS AT THE PELOTAS 2004 BIRTH COHORT STUDY

2019 ◽  
Author(s):  
Marilia Cruz Guttier ◽  
Raquel Siqueira Barcelos ◽  
Rodrigo Wiltgen Ferreira ◽  
Caroline Cardozo Bortolotto ◽  
William Dartora ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Family History ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Birth Cohort ◽  
High Blood Pressure ◽  
Z Scores ◽  
History Of ◽  
Family History Of Hypertension

Abstract Background: We evaluated the prevalence and the factors associated with repeated high systolic (SBP) and diastolic blood pressure (DBP) at 6- and 11-year follow-ups of children from the Pelotas (Brazil) 2004 Birth Cohort. Methods: All live births to mothers living in the urban area of Pelotas were enrolled in the cohort. Blood pressure (BP) values were transformed into Z-scores by sex, age, and height. High SBP and DBP were defined as repeated systolic and diastolic BP Z-scores on the ≥95 th percentile at the two follow-ups. Prevalence (95% confidence interval) of repeated high SBP, DBP, and both (SDBP) were calculated. Associations with maternal and child characteristics were explored in crude and adjusted logistic regression analyses. Results: A total of 3,182 cohort participants were analyzed. Prevalence of repeated high SBP, DBP and SDBP was 1.7% (1.2-2.1%), 2.3% (1.8-2.9%) and 1.2% (0.9-1.6%), respectively. Repeated high SBP was associated with males, gestational diabetes mellitus (2.92; 1.13-7.58) and obesity at 11 years (2.44; 1.29-4.59); while repeated high DBP was associated with females, family history of hypertension from both sides (3.95; 1.59-9.85) and gestational age <34 weeks (4.08; 1.52-10.96). Repeated high SDBP was not associated with any of the characteristics investigated . Conclusion: Prevalence of repeated high SBP, DBP, and SDBP were within the expected distribution at the population level. Nonetheless, gestational diabetes mellitus, obesity, family history of hypertension, and prematurity increased the risk of repeated high blood pressure measured at two occasions five years apart.

scholarly journals REPEATED HIGH BLOOD PRESSURE AT 6 AND 11 YEARS AT THE PELOTAS 2004 BIRTH COHORT STUDY

2019 ◽  
Author(s):  
Marilia Cruz Guttier ◽  
Raquel Siqueira Barcelos ◽  
Rodrigo Wiltgen Pereira ◽  
Caroline Cardozo Bortolotto ◽  
William Dartora ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Family History ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Birth Cohort ◽  
High Blood Pressure ◽  
Z Scores ◽  
History Of ◽  
Family History Of Hypertension

Abstract Background We evaluated the prevalence and the factors associated with repeated high systolic (SBP) and diastolic blood pressure (DBP) at 6- and 11-year follow-ups of children from the Pelotas (Brazil) 2004 Birth Cohort. Methods All live births to mothers living in the urban area of Pelotas were enrolled in the cohort. Blood pressure (BP) values were transformed into Z-scores according to sex, age and height. High SBP and DBP were defined as repeated systolic and diastolic BP Z-scores on the ≥95th percentile at the two follow-ups. Prevalence (95% confidence interval) of repeated high SBP, DBP and both (SDBP) were calculated. Associations with maternal and child characteristics were explored in crude and adjusted logistic regression analyses. Results 3182 cohort participants were analyzed. Prevalence of repeated high SBP, DBP and SDBP was 1.7% (1.2-2.1%), 2.3% (1.8-2.9%) and 1.2% (0.9-1.6%), respectively. Repeated high SBP was associated with male sex, gestational diabetes mellitus (2.92; 1.13-7.58) and obesity at 11 years (2.44; 1.29-4.59); while repeated high DBP was associated with female sex, family history of hypertension from both sides (3.95; 1.59-9.85) and gestational age <34 weeks (4.08; 1.52-10.96). Repeated high SDBP was not associated with any of the characteristcs investigated. Conclusion Prevalence of repeated high SBP, DBP and SDBP were within the expected distribution at the population level. Nonethless, gestational diabetes mellitus, obesity, family history of hypertension, and prematurity increased the risk of repeated high blood pressure measured at two occasions five years apart.

scholarly journals Nomogram-Based Prognostic Model to predict the High blood pressure in Children and Adolescents: Findings from 342,736 individuals in China

2021 ◽  
Author(s):  
Jinghong Liang ◽  
Yu Zhao ◽  
Yican Chen ◽  
Shan Huang ◽  
Shuxin Zhang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Family History ◽  
Children And Adolescents ◽  
High Blood Pressure ◽  
Weight Status ◽  
Gestational Hypertension ◽  
Characteristic Curve ◽  
Penalized Regression ◽  
Training Group ◽  
History Of

Background: Predicting the potential risk factors of High blood pressure(HBP) among children and adolescents is still a knowledge gap. Our study aimed to establish and validate a nomogram-based model for identifying children and adolescents at risk of developing HBP based on a population-based prospective study.<br /> Methods: Hypertension was defined as systolic blood pressure or diastolic blood pressure above 95th percentile, using age, gender and height-specific cut-points. Penalized regression with Lasso was used to identify the strongest predictors of hypertension. Internal validation was conducted by 5-fold cross-validation and bootstrapping approach. The predictive variables were identified along with the advanced nomogram plot by conducting univariate and multivariate logistic regression analyses. A nomogram was constructed by training group comprised of 239,546(69.89%)participants and subsequently validated by externally group with 103,190(30.11%)participants.<br /> Results: Of 342,736 children and adolescents, a total of 55,480(16.19%) youths were identified with HBP with mean age 11.51±1.45 year and 183,487 were boys(53.5%). Nine significant relevant predictors were identified including: age, gender, weight status, birthweight, breastfeeding, gestational hypertension, family history of obesity, 46family history of hypertension and physical activity. An acceptable discrimination[Area under the receiver operating characteristic curve(AUC):0.742(Development group), 0.740(Validation group)] and good calibration(Hosmer and Lemeshow statistics, P ? 0.05) were observed in our models. An available web-based nomogram was built online.<br /> Conclusions: This model composed of age, gender, early life factors, family history of disease, and lifestyle factors may predict the risk of HBP among children and adolescents, which has developed a promising nomogram that may aid in more accurately for identifying the HBP among youths in primary care. <br />Funding Sources: The work was supported by the National Natural Science Foundation of China (No. 81673193).

Sign in / Sign up

Export Citation Format

Share Document