scholarly journals Knowledge, attitudes and practices of West Africans on genetic studies of stroke: Evidence from the SIREN Study

2018 ◽  
Vol 14 (1) ◽  
pp. 69-79 ◽  
Author(s):  
Rufus O Akinyemi ◽  
Fred S Sarfo ◽  
Joshua Akinyemi ◽  
Arti Singh ◽  
Matthew Onoja Akpa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Genetic Testing ◽  
Family History ◽  
High Blood Pressure ◽  
Stroke Patients ◽  
Genetic Studies ◽  
Attitudes And Practices ◽  
Heritable Disorder ◽  
History Of ◽  
Knowledge Attitudes And Practices

Background It is crucial to assess genomic literacy related to stroke among Africans in preparation for the ethical, legal and societal implications of the genetic revolution which has begun in Africa. Objective To assess the knowledge, attitudes and practices (KAP) of West Africans about stroke genetic studies. Methods A comparative cross-sectional study was conducted among stroke patients and stroke-free controls recruited across 15 sites in Ghana and Nigeria. Participants' knowledge of heritability of stroke, willingness to undergo genetic testing and perception of the potential benefits of stroke genetic research were assessed using interviewer-administered questionnaire. Descriptive, frequency distribution and multiple regression analyses were performed. Results Only 49% of 2029 stroke patients and 57% of 2603 stroke-free individuals knew that stroke was a heritable disorder. Among those who knew, 90% were willing to undergo genetic testing. Knowledge of stroke heritability was associated with having at least post-secondary education (OR 1.51, 1.25–1.81) and a family history of stroke (OR 1.20, 1.03–1.39) while Islamic religion (OR=0.82, CI: 0.72–0.94), being currently unmarried (OR = 0.81, CI: 0.70–0.92), and alcohol use (OR = 0.78, CI: 0.67–0.91) were associated with lower odds of awareness of stroke as a heritable disorder. Willingness to undergo genetic testing for stroke was associated with having a family history of stroke (OR 1.34, 1.03–1.74) but inversely associated with a medical history of high blood pressure (OR = 0.79, 0.65–0.96). Conclusion To further improve knowledge of stroke heritability and willingness to embrace genetic testing for stroke, individuals with less formal education, history of high blood pressure and no family history of stroke require targeted interventions.

scholarly journals Evaluation of the Knowledge, Attitudes and Practices of the Hospital Staff in the Management of High Blood Pressure in Conakry

2019 ◽  
Vol 09 (05) ◽  
pp. 354-359
Author(s):  
Ibrahima Sory Sylla ◽  
Djibril Sylla ◽  
Elhadj Yaya Baldé ◽  
Aissatou Barry ◽  
Mabintou Condé ◽  
...  
Keyword(s):  
Blood Pressure ◽  
High Blood Pressure ◽  
Hospital Staff ◽  
Attitudes And Practices ◽  
Knowledge Attitudes And Practices

Increased Erythrocyte Lithium-Sodium Countertransport in Essential Hypertension: Its Relationship to Family History of Hypertension

1981 ◽  
Vol 61 (s7) ◽  
pp. 13s-15s ◽  
Author(s):  
M. Canali ◽  
L. Borghi ◽  
E. Sani ◽  
A. Curti ◽  
A. Montanari ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Family History ◽  
High Blood Pressure ◽  
Degree Relative ◽  
Mean Values ◽  
The Family ◽  
History Of ◽  
Family History Of Hypertension ◽  
And Control

1. Erythrocyte lithium—sodium counter-transport was measured in 46 normotensive healthy controls without family history of hypertension, 15 subjects with essential hypertension, but without evidence of family history of high blood pressure, and 43 subjects with essential hypertension and at least one hypertensive first-degree relative. 2. Mean values (mmol h−1 l−1 of erythrocytes) were 0.248 ± 0.092 in controls, 0.258 ± 0.087 in hypertensive subjects without family history (not significant vs controls), 0.360 ± 0.115 in hypertensive subjects with family history of hypertension (P < 0.001 vs controls), 0.334 ± 0.117 in all hypertensive subjects, both with and without family history (P < 0.001 vs controls). 3. Our data confirm the finding of an increased erythrocyte lithium-sodium counter-transport, but with a significant overlap between essential hypertension and control values. Lithium-sodium countertransport is higher only in hypertensive subjects with at least one hypertensive first-degree relative. 4. We suggest that the increase of lithium-sodium countertransport in erythrocytes is not a consistent marker of essential hypertension. It seems to be associated with the family prevalence and/or the hereditability of hypertension, rather than with high blood pressure per se.

scholarly journals REPEATED HIGH BLOOD PRESSURE AT 6 AND 11 YEARS AT THE PELOTAS 2004 BIRTH COHORT STUDY

2019 ◽  
Author(s):  
Marilia Cruz Guttier ◽  
Raquel Siqueira Barcelos ◽  
Rodrigo Wiltgen Ferreira ◽  
Caroline Cardozo Bortolotto ◽  
William Dartora ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Family History ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Birth Cohort ◽  
High Blood Pressure ◽  
Z Scores ◽  
History Of ◽  
Family History Of Hypertension

Abstract Background: We evaluated the prevalence and the factors associated with repeated high systolic (SBP) and diastolic blood pressure (DBP) at 6- and 11-year follow-ups of children from the Pelotas (Brazil) 2004 Birth Cohort. Methods: All live births to mothers living in the urban area of Pelotas were enrolled in the cohort. Blood pressure (BP) values were transformed into Z-scores by sex, age, and height. High SBP and DBP were defined as repeated systolic and diastolic BP Z-scores on the ≥95 th percentile at the two follow-ups. Prevalence (95% confidence interval) of repeated high SBP, DBP, and both (SDBP) were calculated. Associations with maternal and child characteristics were explored in crude and adjusted logistic regression analyses. Results: A total of 3,182 cohort participants were analyzed. Prevalence of repeated high SBP, DBP and SDBP was 1.7% (1.2-2.1%), 2.3% (1.8-2.9%) and 1.2% (0.9-1.6%), respectively. Repeated high SBP was associated with males, gestational diabetes mellitus (2.92; 1.13-7.58) and obesity at 11 years (2.44; 1.29-4.59); while repeated high DBP was associated with females, family history of hypertension from both sides (3.95; 1.59-9.85) and gestational age <34 weeks (4.08; 1.52-10.96). Repeated high SDBP was not associated with any of the characteristics investigated . Conclusion: Prevalence of repeated high SBP, DBP, and SDBP were within the expected distribution at the population level. Nonetheless, gestational diabetes mellitus, obesity, family history of hypertension, and prematurity increased the risk of repeated high blood pressure measured at two occasions five years apart.

scholarly journals Knowledge, Attitudes, and Practices toward Breast Cancer

2020 ◽  
pp. 25-32
Author(s):  
Hesam Adin Atashi ◽  
Mohammad Eslami Vaghar ◽  
Maedeh Olya ◽  
Parisa Mirzamohammadi ◽  
Hamid Zaferani Arani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Screening ◽  
Family History ◽  
Early Detection ◽  
Marital Status ◽  
Breast Cancer Screening ◽  
Positive Family History ◽  
Attitudes And Practices ◽  
History Of ◽  
Knowledge Attitudes And Practices

Background: The incidence of breast cancer is rising rapidly worldwide. Midwives have an important role in early detection of the disease by providing the patients with awareness and an accurate Clinical Breast Examination (CBE) of the patients that are effective in early detections. This study investigated the knowledge, attitudes and practices of midwives toward breast cancer.Methods: The study was conducted on 210 of midwives aged 20-62 who participated in a seminar for clarifying the role of knowledge, attitudes and practices in breast cancer early detection and prevention. The data were collected using a standard questionnaire which has 4 sections with 55 items including age, educational level, number of family members, marital status, family history of breast cancer and their knowledge, attitude and practices about breast cancer screening. Data were analyzed using SPSS version 13.0.Results: About two-third of the participants (65.9%) had excellent knowledge about the signs and symptoms of breast cancer. The results revealed that 30.8% of respondents performed self-examination once a month. There was a significant correlation between the knowledge of breast cancer and adopting preventive practices (P = 0.02). The level of their attitude was significantly associated with a positive family history of breast cancer (P= 0.03). There was no significant relationship between marital status or family history of breast cancer with CBE. Conclusion: An appropriate level of knowledge and practice of breast cancer screening was observed to help prevention among midwives. The findings can have remarkable practical implications as midwives can play an important role to broaden the breast-cancer-related knowledge of women.

scholarly journals REPEATED HIGH BLOOD PRESSURE AT 6 AND 11 YEARS AT THE PELOTAS 2004 BIRTH COHORT STUDY

2019 ◽  
Author(s):  
Marilia Cruz Guttier ◽  
Raquel Siqueira Barcelos ◽  
Rodrigo Wiltgen Pereira ◽  
Caroline Cardozo Bortolotto ◽  
William Dartora ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Family History ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Birth Cohort ◽  
High Blood Pressure ◽  
Z Scores ◽  
History Of ◽  
Family History Of Hypertension

Abstract Background We evaluated the prevalence and the factors associated with repeated high systolic (SBP) and diastolic blood pressure (DBP) at 6- and 11-year follow-ups of children from the Pelotas (Brazil) 2004 Birth Cohort. Methods All live births to mothers living in the urban area of Pelotas were enrolled in the cohort. Blood pressure (BP) values were transformed into Z-scores according to sex, age and height. High SBP and DBP were defined as repeated systolic and diastolic BP Z-scores on the ≥95th percentile at the two follow-ups. Prevalence (95% confidence interval) of repeated high SBP, DBP and both (SDBP) were calculated. Associations with maternal and child characteristics were explored in crude and adjusted logistic regression analyses. Results 3182 cohort participants were analyzed. Prevalence of repeated high SBP, DBP and SDBP was 1.7% (1.2-2.1%), 2.3% (1.8-2.9%) and 1.2% (0.9-1.6%), respectively. Repeated high SBP was associated with male sex, gestational diabetes mellitus (2.92; 1.13-7.58) and obesity at 11 years (2.44; 1.29-4.59); while repeated high DBP was associated with female sex, family history of hypertension from both sides (3.95; 1.59-9.85) and gestational age <34 weeks (4.08; 1.52-10.96). Repeated high SDBP was not associated with any of the characteristcs investigated. Conclusion Prevalence of repeated high SBP, DBP and SDBP were within the expected distribution at the population level. Nonethless, gestational diabetes mellitus, obesity, family history of hypertension, and prematurity increased the risk of repeated high blood pressure measured at two occasions five years apart.

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