A2714 The efficacy of low-salt diet education in hypertensive patients

ABSTRACTHypertension is still the most highest causes of death in Indonesia . Patient with hypertension not knowing that they have hypertension and in the end they have complications of hypertension, so it is often called the silent killer disease. Things that can be do so hypertension does not get worse is do a low salt diet. This study aims to determine the application of a low salt diet in patients with hypertension. The research method uses a traditional literature review, articles used by Portal Garuda and Google Scholar with a range of 2016-2020. The keywords used in the article search were low salt diet, hypertension. The results of the search for articles obtained on the Portal Garuda are 12 articles on Google Scholar are 4,030 articles, of which are only 15 articles that match the topic. Patients with hypertension mostly adhere to a low salt diet but there are still many who do not adhere to a low salt diet. Knowledge, attitude, family support and self awareness are factors that affects hypertension. The conclusion in this study, the application of a low-salt diet in hypertensive patients can be carried out well, hypertensive patients have knowledge, attitude and good family support for the implementation of a low salt diet and hypertensive patients who have the awareness to control their blood pressure. Suggestions for health workers can provide counseling regarding a low salt diet, for people with hypertension to apply a low salt diet properly so that blood pressure can be controlled.

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LITERATURE REVIEW: LOW SALT DIET IN PATIENT WITH HYPERTENSION

Indonesian Midwifery and Health Sciences Journal ◽

10.20473/imhsj.v5i2.2021.198-208 ◽

2021 ◽

Vol 5 (2) ◽

pp. 224

Author(s):

Nisrina Nur Zahidah

Keyword(s):

Blood Pressure ◽

Literature Review ◽

Family Support ◽

Health Workers ◽

Google Scholar ◽

Self Awareness ◽

Salt Diet ◽

Hypertensive Patients ◽

Knowing That ◽

Low Salt

ABSTRACTHypertension is still the most highest causes of death in Indonesia . Patient with hypertension not knowing that they have hypertension and in the end they have complications of hypertension, so it is often called the silent killer disease. Things that can be do so hypertension does not get worse is do a low salt diet. This study aims to determine the application of a low salt diet in patients with hypertension. The research method uses a traditional literature review, articles used by Portal Garuda and Google Scholar with a range of 2016-2020. The keywords used in the article search were low salt diet, hypertension. The results of the search for articles obtained on the Portal Garuda are 12 articles on Google Scholar are 4,030 articles, of which are only 15 articles that match the topic. Patients with hypertension mostly adhere to a low salt diet but there are still many who do not adhere to a low salt diet. Knowledge, attitude, family support and self awareness are factors that affects hypertension. The conclusion in this study, the application of a low-salt diet in hypertensive patients can be carried out well, hypertensive patients have knowledge, attitude and good family support for the implementation of a low salt diet and hypertensive patients who have the awareness to control their blood pressure. Suggestions for health workers can provide counseling regarding a low salt diet, for people with hypertension to apply a low salt diet properly so that blood pressure can be controlled.

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Erderly Behavior Factors Affecting Compliance of Hypertension Patients at Mitra Medan Public Hospital

Journal Wetenskap Health ◽

10.48173/jwh.v1i2.32 ◽

2020 ◽

Vol 1 (2) ◽

pp. 17-35

Author(s):

Lingse Elsina Sianipar ◽

Razia Begum Suroyo ◽

Muhammad Badiran ◽

Yuniati Yuniati

Keyword(s):

Family Support ◽

Public Hospital ◽

Health Workers ◽

The Elderly ◽

Pressure Control ◽

Regular Exercise ◽

Salt Diet ◽

Hypertensive Patients ◽

Factors Affecting ◽

Low Salt

The prevalence of hypertension continues to increase from year to year, especially in the elderly. The high number of cases of hypertension is thought to be due to a lack of compliance in complying with the recommendations of health workers such as carrying out routine checks (blood pressure control), taking medication regularly, adopting a low-salt diet, and doing regular exercise. The purpose of this study was to analyze the behavioral factors of the elderly that influenced hypertension patient compliance.The results showed that the factors that influenced the compliance of hypertensive patients at Mitra Medika General Hospital Medan were knowledge, motivation, insurance participation, and family support. Meanwhile, the variables that did not influence were age, gender, health facilities, distance, and support for health workers. The conclusion of this research is that knowledge, motivation, insurance participation and family support affect the compliance of hypertensive patients.

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E083 Comparative efficacy of a low-salt diet, nifedipine-gits, hydrochlorothiazide and their combinations in salt-sensitive black hypertensive patients assessed by 24-H BP monitoring

American Journal of Hypertension ◽

10.1016/s0895-7061(97)91145-6 ◽

1998 ◽

Vol 11 (4) ◽

pp. 116A

Author(s):

A DAMASCENO

Keyword(s):

Comparative Efficacy ◽

Salt Diet ◽

Hypertensive Patients ◽

Low Salt

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Urea and NaCl regulate UT-A1 urea transporter in opposing directions via TonEBP pathway during osmotic diuresis

AJP Renal Physiology ◽

10.1152/ajprenal.00143.2008 ◽

2009 ◽

Vol 296 (1) ◽

pp. F67-F77 ◽

Cited By ~ 12

Author(s):

Yu-Mi Kim ◽

Wan-Young Kim ◽

Hyun-Wook Lee ◽

Jin Kim ◽

H. Moo Kwon ◽

...

Keyword(s):

Transcription Factor ◽

Plasma Osmolality ◽

Urea Concentration ◽

Urea Transporter ◽

Osmotic Diuresis ◽

High Salt Diet ◽

Salt Diet ◽

Low Protein ◽

Low Salt ◽

Urine Concentrating Ability

In our previous studies of varying osmotic diuresis, UT-A1 urea transporter increased when urine and inner medullary (IM) interstitial urea concentration decreased. The purposes of this study were to examine 1) whether IM interstitial tonicity changes with different urine urea concentrations during osmotic dieresis and 2) whether the same result occurs even if the total urinary solute is decreased. Rats were fed a 4% high-salt diet (HSD) or a 5% high-urea diet (HUD) for 2 wk and compared with the control rats fed a regular diet containing 1% NaCl. The urine urea concentration decreased in HSD but increased in HUD. In the IM, UT-A1 and UT-A3 urea transporters, CLC-K1 chloride channel, and tonicity-enhanced binding protein (TonEBP) transcription factor were all increased in HSD and decreased in HUD. Next, rats were fed an 8% low-protein diet (LPD) or a 0.4% low-salt diet (LSD) to decrease the total urinary solute. Urine urea concentration significantly decreased in LPD but significantly increased in LSD. Rats fed the LPD had increased UT-A1 and UT-A3 in the IM base but decreased in the IM tip, resulting in impaired urine concentrating ability. The LSD rats had decreased UT-A1 and UT-A3 in both portions of the IM. CLC-K1 and TonEBP were unchanged by LPD or LSD. We conclude that changes in CLC-K1, UT-A1, UT-A3, and TonEBP play important roles in the renal response to osmotic diuresis in an attempt to minimize changes in plasma osmolality and maintain water homeostasis.

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Renal effects of the serine protease inhibitor aprotinin in healthy conscious mice

Acta Pharmacologica Sinica ◽

10.1038/s41401-021-00628-1 ◽

2021 ◽

Author(s):

Stefan Wörner ◽

Bernhard N. Bohnert ◽

Matthias Wörn ◽

Mengyun Xiao ◽

Andrea Janessa ◽

...

Keyword(s):

Protease Inhibitor ◽

Serine Protease ◽

Kidney Injury ◽

Serine Protease Inhibitor ◽

Tubular Function ◽

Proteolytic Activation ◽

Salt Diet ◽

Low Salt ◽

Proximal Tubular ◽

Proximal Tubular Function

AbstractTreatment with aprotinin, a broad-spectrum serine protease inhibitor with a molecular weight of 6512 Da, was associated with acute kidney injury, which was one of the reasons for withdrawal from the market in 2007. Inhibition of renal serine proteases regulating the epithelial sodium channel ENaC could be a possible mechanism. Herein, we studied the effect of aprotinin in wild-type 129S1/SvImJ mice on sodium handling, tubular function, and integrity under a control and low-salt diet. Mice were studied in metabolic cages, and aprotinin was delivered by subcutaneously implanted sustained release pellets (2 mg/day over 10 days). Mean urinary aprotinin concentration ranged between 642 ± 135 (day 2) and 127 ± 16 (day 8) µg/mL . Aprotinin caused impaired sodium preservation under a low-salt diet while stimulating excessive hyperaldosteronism and unexpectedly, proteolytic activation of ENaC. Aprotinin inhibited proximal tubular function leading to glucosuria and proteinuria. Plasma urea and cystatin C concentration increased significantly under aprotinin treatment. Kidney tissues from aprotinin-treated mice showed accumulation of intracellular aprotinin and expression of the kidney injury molecule 1 (KIM-1). In electron microscopy, electron-dense deposits were observed. There was no evidence for kidney injury in mice treated with a lower aprotinin dose (0.5 mg/day). In conclusion, high doses of aprotinin exert nephrotoxic effects by accumulation in the tubular system of healthy mice, leading to inhibition of proximal tubular function and counterregulatory stimulation of ENaC-mediated sodium transport.

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