Major Depressive Disorder With Anger Attacks and Subcortical MRI White Matter Hyperintensities

2007 ◽  
Vol 195 (2) ◽  
pp. 175-178 ◽  
Author(s):  
Dan V. Iosifescu ◽  
Perry F. Renshaw ◽  
Darin D. Dougherty ◽  
In Kyoon Lyoo ◽  
Ho Kyu Lee ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
White Matter ◽  
Depressive Disorder ◽  
White Matter Hyperintensities ◽  
Major Depressive ◽  
Anger Attacks

scholarly journals Brain white-matter hyperintensities and treatment outcome in major depressive disorder

2006 ◽  
Vol 188 (2) ◽  
pp. 180-185 ◽  
Author(s):  
Dan V. Iosifescu ◽  
Perry F. Renshaw ◽  
In Kyoon Lyoo ◽  
Ho Kyu Lee ◽  
Roy H. Perlis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Major Depressive Disorder ◽  
Treatment Outcome ◽  
Cardiovascular Risk ◽  
White Matter ◽  
Depressive Disorder ◽  
Cardiovascular Risk Factors ◽  
White Matter Hyperintensities ◽  
Major Depressive ◽  
Brain White Matter

BackgroundAn increased incidence of brain white-matter hyperintensities has been described in major depressive disorder, but the impact of such hyperintensities on treatment outcome is still controversial.AimsTo investigate the relationship of brain white-matter hyperintensities with cardiovascular risk factors and with treatment outcome in younger people with major depressive disorder.MethodWe assessed brain white-matter hyperintensities and cardiovascular risk factors in 84 people with major depressive disorder prior to initiating antidepressanttreatment. We also assessed hyperintensities in 35 matched controls.ResultsWe found no significant difference in the prevalence of white-matter hyperintensities between the depression and the control groups. Left-hemisphere subcortical hyperintensities correlated with lower rates of treatment response. We found no correlation between global hyperintensity measures and clinical outcome. Brain white-matter hyperintensities correlated with hypertension and age and with total cardiovascular risk score.ConclusionsSubcortical white-matter hyperintensities in the left hemisphere (but not in other brain areas) may be associated with poor response to antidepressant treatment in major depression.

Brain MRI white matter hyperintensities and one-carbon cycle metabolism in non-geriatric outpatients with major depressive disorder (Part I)

2005 ◽  
Vol 140 (3) ◽  
pp. 291-299 ◽  
Author(s):  
Dan V. Iosifescu ◽  
George I. Papakostas ◽  
In Kyoon Lyoo ◽  
Ho Kyu Lee ◽  
Perry F. Renshaw ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
White Matter ◽  
Depressive Disorder ◽  
Carbon Cycle ◽  
White Matter Hyperintensities ◽  
Brain Mri ◽  
Major Depressive

Brain MRI white matter hyperintensities and one-carbon cycle metabolism in non-geriatric outpatients with major depressive disorder (Part II)

2005 ◽  
Vol 140 (3) ◽  
pp. 301-307 ◽  
Author(s):  
George I. Papakostas ◽  
Dan V. Iosifescu ◽  
Perry F. Renshaw ◽  
In Kyoon Lyoo ◽  
Ho Kyu Lee ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
White Matter ◽  
Depressive Disorder ◽  
Carbon Cycle ◽  
White Matter Hyperintensities ◽  
Brain Mri ◽  
Major Depressive

scholarly journals Cortico-Cortical White Matter Motor Pathway Microstructure Is Related to Psychomotor Retardation in Major Depressive Disorder

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e52238 ◽  
Author(s):  
Tobias Bracht ◽  
Andrea Federspiel ◽  
Susanne Schnell ◽  
Helge Horn ◽  
Oliver Höfle ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
White Matter ◽  
Depressive Disorder ◽  
Psychomotor Retardation ◽  
Major Depressive ◽  
Motor Pathway
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