Bone Mass, Bone Geometry, and Body Composition in Female-to-Male Transsexual Persons After Long-term Cross-Sex Hormonal Therapy

Background: Currently, the two most common bariatric procedures are laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB). Long-term data comparing the two interventions in terms of their effect on body composition and bone mass density (BMD) are scarce. Objective: The aim of this study was to assess body composition and BMD at least 5 years after LSG and LRYGB. Setting: Department of Endocrinology and Nutrition, St. Claraspital Basel and St. Clara Research Ltd., Basel, Switzerland. Methods:Bariatric patients at least 5 years after surgery (LSG or LRYGB) were recruited, and body composition and BMD were measured by means of dual-energy X-ray absorptiometry. Data from body composition before surgery were included in the analysis. Blood samples were taken for determination of plasma calcium, parathyroid hormone, vitamin D3, alkaline phosphatase, and C-terminal telopeptide, and the individual risk for osteoporotic fracture assessed by the Fracture Risk Assessment Tool score was calculated. After surgery, all patients received multivitamins, vitamin D3, and zinc. In addition, LRYGB patients were prescribed calcium. Results: A total of 142 patients were included, 72 LSG and 70 LRYGB, before surgery: median body mass index 43.1, median age 45.5 years, 62.7% females. Follow-up after a median of 6.7 years. For LRYGB, the percentage total weight loss at follow-up was 26.3% and for LSG 24.1% (p = 0.243). LRYGB led to a slightly lower fat percentage in body composition. At follow-up, 45% of both groups had a T score at the femoral neck below –1, indicating osteopenia. No clinically relevant difference in BMD was found between the groups. Conclusions:At 6.7 years after surgery, no difference in body composition and BMD between LRYGB and LSG was found. Deficiencies and bone loss remain an issue after both interventions and should be monitored.

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Body Composition, Bone Mass and Bone Geometry in Adolescent Athletes

Medicine & Science in Sports & Exercise ◽

10.1249/01.mss.0000562540.84191.35 ◽

2019 ◽

Vol 51 (Supplement) ◽

pp. 681-682

Author(s):

Raiany R. Bergamo ◽

Humberto M. de Carvalho ◽

Gil Guerra-Junior ◽

Anderson M. de Moraes

Keyword(s):

Body Composition ◽

Bone Mass ◽

Bone Geometry ◽

Adolescent Athletes

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Long-term effects of laparoscopic sleeve gastrectomy and Roux-Y-gastric bypass on body composition and bone mass density

British Journal of Surgery ◽

10.1093/bjs/znab202.040 ◽

2021 ◽

Vol 108 (Supplement_4) ◽

Author(s):

S Rast ◽

J Bühler ◽

C Beglinger ◽

R Peterli ◽

T Peters ◽

...

Keyword(s):

Gastric Bypass ◽

Body Composition ◽

Sleeve Gastrectomy ◽

Bone Mass ◽

Vitamin D3 ◽

Mass Density ◽

Bone Mass Density ◽

Post Surgery

Abstract Objective Currently, the two most common bariatric procedures are laparoscopic sleeve gastrectomy (LSG) and laparoscopic gastric bypass (LRYGB). Long-term data comparing the two interventions in terms of their effect on body composition and bone mass density (BMD) is scarce. The aim of this study was to assess body composition and BMD at least five years after sleeve gastrectomy (LSG) and gastric bypass (LRYGB). Methods Bariatric patients at least five years post-surgery (LSG or LRYGB) were recruited and body composition and BMD was measured by means of DEXA. Data from body composition before surgery was included in the analysis. Blood samples were taken for determination of plasma calcium, parathyroid hormone (PTH), Vitamin D3, alkaline phosphatase and C-terminal telopeptide (CTX), and individual risk for osteoporotic fracture assessed by The Fracture Risk Assessment Tool (FRAX) score was calculated. After surgery, all patients received multivitamins, vitamin D3, and zinc. In addition, LRYGB-patients were prescribed calcium. Results A total of 142 patients were included, 72 LSG and 70 LRYGB, before surgery: median BMI 43.1 kg/m2, median age 45.5 years, 62.7% females. Follow-up after a median of 6.7 years. For LRYGB, percentage total weight loss (%TWL) at follow up was 26.3%, and for LSG 24.1%, (p = 0.243). LRYGB lead to a slightly lower fat percentage in body composition. At follow-up, 45% of both groups had a T-score at the femoral neck below -1, indicating osteopenia. No clinically relevant difference between the groups in BMD was found. Conclusion At 6.7 years post-surgery, no difference in body composition and BMD between LRYGB and LSG was found. Deficiencies and bone loss remain an issue after both interventions and should be monitored.

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Long term effects of normal calcium–high fat diets on body composition and bone mass, in rats

Bone ◽

10.1016/j.bone.2009.08.047 ◽

2009 ◽

Vol 45 (6) ◽

pp. S157

Author(s):

E. Hernández ◽

C. Suarez ◽

A. Ferreira Monteiro ◽

P. Rodriguez ◽

M. Gonzáles-Chaves ◽

...

Keyword(s):

Body Composition ◽

Bone Mass ◽

Long Term Effects ◽

High Fat ◽

High Fat Diets ◽

Fat Diets ◽

Normal Calcium

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Bone Mass, Bone Geometry and Body Composition in Female-to-Male Transsexual Persons

10.1210/endo-meetings.2011.part2.p25.p2-110 ◽

2011 ◽

pp. P2-110-P2-110

Author(s):

Eva Van Caenegem ◽

Katrien Wierckx ◽

David Dedecker ◽

Fleur Van de Peer ◽

Kaatje Toye ◽

...

Keyword(s):

Body Composition ◽

Bone Mass ◽

Bone Geometry

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Bone and Body Composition Analyses by Dxa in Adults With Gh Deficiency: Effects of Long-term Replacement Therapy

10.21203/rs.3.rs-260021/v1 ◽

2021 ◽

Author(s):

Alessandro Rossini ◽

Roberto Lanzi ◽

Carlotta Galeone ◽

Claudio Pelucchi ◽

Mario Pennacchioni ◽

...

Keyword(s):

Body Composition ◽

Lumbar Spine ◽

Bone Mass ◽

Replacement Therapy ◽

Gh Deficiency ◽

Response To Treatment ◽

Long Term Effects ◽

Mineral Density ◽

The Impact

Abstract Purpose: The effects of growth hormone (GH) replacement on bone mass and body composition in adult with GH deficiency (AGHD) are still debated with regard to their persistence in the long term. Moreover, the impact of gender on the response to GH is controversial. Aim of this study was to evaluate the long-term effects of rhGH replacement on bone mass and body composition in a monocentric cohort of patients with AGHD.Methods: Data from 138 patients with AGHD (34.3 ± 14.3 years, 48 women and 90 men) treated with rhGH for a period of at least 3 years up to a maximum of 10 were retrospectively collected. Bone mineral density (BMD) at the lumbar spine, femur, and radius, and total and truncular body composition were evaluated by dual energy X-ray absorption (DXA) before and during treatment. Clinical and laboratory evaluations were performed before and during the treatment period on an annual basis.Results: Lumbar spine BMD consistently increased in males, while in females decreased after a transient improvement observed during the first 4 years of therapy. There were no significant changes in femoral BMD in either sexes, while a progressive increase at radius was observed only in males. Lean mass significantly increased in both sexes, while fat mass decreased only in males.Conclusions: In AGHD patients long-term rhGH replacement therapy induces a positive effect with regard to bone mass and body composition. A sexual dimorphism in the response to treatment is evident, with males displaying more favorable outcome.

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Can the sedentary behavior of young male basketball and volleyball players impact the bone mass and bone geometry?

10.21203/rs.3.rs-51216/v1 ◽

2020 ◽

Author(s):

Mauricio Etchebehere ◽

Raiany Rosa Bergamo ◽

Humberto Moreira Carvalho ◽

Anderson Marques de Moraes ◽

Gil Guerra-Junior

Keyword(s):

Body Composition ◽

Bone Mass ◽

Sedentary Behavior ◽

Bone Mineral ◽

Young Male ◽

Bone Geometry ◽

Strength Index ◽

Cross Sectional ◽

Uncertainty Estimates ◽

Volleyball Players

Abstract Background: Sedentary behavior is considered a health risk independent of physical activity. We evaluated the relationship between sedentary behavior, bone mass, and bone geometry among young male basketball and volleyball players.Methods: Fifty-five athletes (basketball n=21; volleyball n=34) aged 14 to 17 years old were included. Body composition and bone mass were measured by dual-energy X-ray absorptiometry, comprising bone mineral density, bone mineral content at the lumbar spine (L1-L4), and femoral neck. Bone quality was evaluated by bone geometry considering the femur strength index, section modulus, cross-sectional moment of inertia, and cross-sectional area. Information on all foods and beverages were obtained by a nutritionist through a 24-hour food recall and a semi-quantitative food frequency questionnaire. The sedentary behavior was assessed using the Adolescent Sedentary Activity Questionnaire. A series of multilevel linear regression models were fitted to explore whether there was variation for players' body composition, bone parameters, diary nutrient intake and sedentary behavior by sport. All models were fitted using Bayesian methods.Results: Body composition and bone mass values were high for both basketball and volleyball players. However, there was no substantial variation between players by sport for body composition. Adjusting for age, there was no association of sedentary behavior on both bone mass and geometry among the athletes. Except for femoral strength index, age had a substantial moderate to large association with all bone mass and geometry indicators. Lastly, there was no substantial influence of sport (level-2 unit) on the estimates of the association between sedentary behavior and age with bone mass and geometry, as uncertainty estimates for group-level effects were high. Conclusions: In conclusion, there is no association between sedentary behaviour and bone mass and bone geometry, showing that accumulated training loads (15+ h/week) among young basketball and volleyball players are critical; they produce a positive stimulus on bone mass and bone geometry development.

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Long-term childhood body mass index and adult bone mass are linked through concurrent body mass index and body composition

Bone ◽

10.1016/j.bone.2019.01.027 ◽

2019 ◽

Vol 121 ◽

pp. 259-266 ◽

Cited By ~ 1

Author(s):

Hongbo Dong ◽

Junting Liu ◽

Yinkun Yan ◽

Dongqing Hou ◽

Xiaoyuan Zhao ◽

...

Keyword(s):

Body Mass Index ◽

Body Composition ◽

Bone Mass ◽

Body Mass ◽

Childhood Body Mass Index ◽

Adult Bone

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Can the sedentary behavior of basketball and volleyball players impact bone mass and bone geometry?

International Journal of Sports Science & Coaching ◽

10.1177/17479541211064415 ◽

2021 ◽

pp. 174795412110644

Author(s):

Mauricio Etchebehere ◽

Raiany Rosa Bergamo ◽

Humberto Moreira Carvalho ◽

Anderson Marques de Moraes ◽

Gil Guerra-Júnior

Keyword(s):

Body Composition ◽

Bone Mass ◽

Sedentary Behavior ◽

Bone Mineral ◽

Bone Geometry ◽

Strength Index ◽

Cross Sectional ◽

Bone Parameters ◽

Uncertainty Estimates ◽

Volleyball Players

The aim of the study was to evaluate the relationship between sedentary behavior, bone mass, and bone geometry among young male basketball and volleyball players. This cross-sectional study included 55 adolescent basketball ( n = 21) and volleyball ( n = 34) players (14–17 years). Body composition (body mass index, fat mass, and lean mass) was measured by dual-energy X-ray absorptiometry, comprising bone mineral density, bone mineral content at the lumbar spine, and femoral neck. Bone geometry considered the femur strength index, section modulus, cross-sectional moment of inertia, and cross-sectional area. Dietary intake was obtained through a semiquantitative questionnaire, and the sedentary behavior, by the Adolescent Sedentary Activity Questionnaire. Linear regression models, fitted by Bayesian methods, explored the variation of the variables by sport. Body composition and bone mass values were high for both sports, but there was no variation for body composition. Adjusting for age, there was no association of sedentary behavior on bone parameters. For femoral strength index, age had a moderate to large association with all bone indicators. Lastly, there was influence of sport (level-2 unit) on the estimates of the association between sedentary behavior and age with bone indicators, as uncertainty estimates for group-level effects were high. There is no association between sedentary behavior and bone parameters, showing that accumulated training loads (15+ h/wk) among young basketball and volleyball players are critical; producing a positive stimulus on bone parameters development.

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