The Upregulation of Cognate and Inducible Heat Shock Proteins in the Anoxic Turtle Brain
2004 ◽
Vol 24
(7)
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pp. 826-828
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Keyword(s):
Because heat shock proteins (HSPs) have an important protective function against ischemia/anoxia in mammalian brain, the authors investigated the expression of Hsp72 and Hsc73 in the anoxia-surviving turtle brain. Unlike the mammalian brain, high levels of Hsp72 were found in the normoxic turtle brain. Hsp72 levels were significantly increased by 4 hours of anoxia, remained constant until 8 hours, and then decreased to baseline at 12 hours. By contrast, Hsc73 was progressively increased throughout 12 hours of anoxia. This differential expression suggests different protective roles: Hsp72 in the initial downregulatory transition phase, and Hsc73 in maintaining neural network integrity during the long-term hypometabolic phase.
1987 ◽
Vol 163
(1)
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pp. 211-220
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Keyword(s):
2017 ◽
Vol 119
(1)
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pp. 359-364
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Keyword(s):
Keyword(s):
1992 ◽
Vol 41
(2)
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pp. 231-238
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Keyword(s):
2002 ◽
Vol 23
(2)
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pp. 103-109
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Keyword(s):
Keyword(s):