AN ASSESSMENT OF THE RELIABILITY OF THE VENTILATORY RESPONSE INDEX RELATIVE TO TRADITIONAL INDICES OF EXERCISE INTENSITY IN HEALTHY ADULTS.

2007 ◽  
Vol 18 (4) ◽  
pp. 30
Author(s):  
Colette K. Gallagher ◽  
Taylor Millican ◽  
Lauren Polivka ◽  
Courtney Schrey ◽  
Steven H. Sadowsky
Keyword(s):  
Exercise Intensity ◽  
Ventilatory Response ◽  
Healthy Adults ◽  
Response Index

AN ASSESSMENT OF THE RELIABILITY OF THE VENTILATORY RESPONSE INDEX RELATIVE TO TRADITIONAL INDICES OF EXERCISE INTENSITY IN HEALTHY ADULTS.

2004 ◽  
Vol 18 (4) ◽  
pp. 30
Author(s):  
Colette K. Gallagher ◽  
Taylor Millican ◽  
Lauren Polivka ◽  
Courtney Schrey ◽  
Steven H. Sadowsky
Keyword(s):  
Exercise Intensity ◽  
Ventilatory Response ◽  
Healthy Adults ◽  
Response Index

scholarly journals Interindividual variability in the dose-specific effect of dopamine on carotid chemoreceptor sensitivity to hypoxia

2016 ◽  
Vol 120 (2) ◽  
pp. 138-147 ◽  
Author(s):  
Jacqueline K. Limberg ◽  
Blair D. Johnson ◽  
Walter W. Holbein ◽  
Sushant M. Ranadive ◽  
Michael T. Mozer ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Ventilatory Response ◽  
Peripheral Resistance ◽  
Specific Effect ◽  
Cardiovascular Responses ◽  
Healthy Adults ◽  
Dopamine Infusion ◽  
Ventilatory Responses ◽  
Body Responsiveness ◽  
Ventilatory Response To Hypoxia

Human studies use varying levels of low-dose (1-4 μg·kg−1·min−1) dopamine to examine peripheral chemosensitivity, based on its known ability to blunt carotid body responsiveness to hypoxia. However, the effect of dopamine on the ventilatory responses to hypoxia is highly variable between individuals. Thus we sought to determine 1) the dose response relationship between dopamine and peripheral chemosensitivity as assessed by the ventilatory response to hypoxia in a cohort of healthy adults, and 2) potential confounding cardiovascular responses at variable low doses of dopamine. Young, healthy adults ( n = 30, age = 32 ± 1, 24 male/6 female) were given intravenous (iv) saline and a range of iv dopamine doses (1–4 μg·kg−1·min−1) prior to and throughout five hypoxic ventilatory response (HVR) tests. Subjects initially received iv saline, and after each HVR the dopamine infusion rate was increased by 1 μg·kg−1·min−1. Tidal volume, respiratory rate, heart rate, blood pressure, and oxygen saturation were continuously measured. Dopamine significantly reduced HVR at all doses ( P < 0.05). When subjects were divided into high ( n = 13) and low ( n = 17) baseline chemosensitivity, dopamine infusion (when assessed by dose) reduced HVR in the high group only ( P < 0.01), with no effect of dopamine on HVR in the low group ( P > 0.05). Dopamine infusion also resulted in a reduction in blood pressure (3 μg·kg−1·min−1) and total peripheral resistance (1–4 μg·kg−1·min−1), driven primarily by subjects with low baseline chemosensitivity. In conclusion, we did not find a single dose of dopamine that elicited a nadir HVR in all subjects. Additionally, potential confounding cardiovascular responses occur with dopamine infusion, which may limit its usage.

scholarly journals Validity of simplified, calibration-less exercise intensity measurement using resting heart rate during sleep: a method-comparison study with respiratory gas analysis

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Hirotaka Matsuura ◽  
Masahiko Mukaino ◽  
Yohei Otaka ◽  
Hitoshi Kagaya ◽  
Yasushi Aoshima ◽  
...  
Keyword(s):  
Heart Rate ◽  
Exercise Intensity ◽  
Method Comparison ◽  
Measurement Model ◽  
Wearable Devices ◽  
Gas Analysis ◽  
Healthy Adults ◽  
Treadmill Testing ◽  
Mean Differences ◽  
Method Comparison Study

Abstract Background The recent development of wearable devices has enabled easy and continuous measurement of heart rate (HR). Exercise intensity can be calculated from HR with indices such as percent HR reserve (%HRR); however, this requires an accurate measurement of resting HR, which can be time-consuming. The use of HR during sleep may be a substitute that considers the calibration-less measurement of %HRR. This study examined the validity of %HRR on resting HR during sleep in comparison to percent oxygen consumption reserve (%VO2R) as a gold standard. Additionally, a 24/7%HRR measurement using this method is demonstrated. Methods Twelve healthy adults aged 29 ± 5 years underwent treadmill testing using the Bruce protocol and a 6-min walk test (6MWT). The %VO2R during each test was calculated according to a standard protocol. The %HRR during each exercise test was calculated either from resting HR in a sitting position (%HRRsitting), when lying awake (%HRRlying), or during sleep (%HRRsleeping). Differences between %VO2R and %HRR values were examined using Bland-Altman plots. A 180-day, 24/7%HRR measurement with three healthy adults was also conducted. The %HRR values during working days and holidays were compared. Results In the treadmill testing, the mean difference between %VO2R and %HRRsleeping was 1.7% (95% confidence interval [CI], − 0.2 to 3.6%). The %HRRsitting and %HRRlying values were 10.8% (95% CI, 8.8 to 12.7%) and 7.7% (95% CI, 5.4 to 9.9%), respectively. In the 6MWT, mean differences between %VO2R and %HRRsitting, %HRRlying and %HRRsleeping were 12.7% (95% CI, 10.0 to 15.5%), 7.0% (95% CI, 4.0 to 10.0%) and − 2.9% (95% CI, − 5.0% to − 0.7%), respectively. The 180-day, 24/7%HRR measurement presented significant differences in %HRR patterns between working days and holidays in all three participants. Conclusions The results suggest %HRRsleeping is valid in comparison to %VO2R. The results may encourage a calibration-less, 24/7 measurement model of exercise intensity using wearable devices. Trial registration UMIN000034967. Registered 21 November 2018 (retrospectively registered).

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