Propofol post-conditioning protects against cardiomyocyte apoptosis in hypoxia/reoxygenation injury by suppressing nuclear factor-kappa B translocation via extracellular signal-regulated kinase mitogen-activated protein kinase pathway

2011 ◽  
Vol 28 (7) ◽  
pp. 525-534 ◽  
Author(s):  
Hao Li ◽  
Jian Tan ◽  
Zui Zou ◽  
Cai-Guo Huang ◽  
Xue-Yin Shi
Keyword(s):  
Protein Kinase ◽  
Nuclear Factor Kappa B ◽  
Cardiomyocyte Apoptosis ◽  
Mitogen Activated Protein Kinase ◽  
Nuclear Factor ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
Mitogen Activated Protein ◽  
Reoxygenation Injury ◽  
Kinase Pathway

scholarly journals Molecular mechanisms of neutrophil apoptosis (review)

2018 ◽  
pp. 5-18
Author(s):  
И.А. Щепеткин ◽  
О.П. Буданова ◽  
И.Ю. Малышев ◽  
Д.Н. Аточин
Keyword(s):  
Protein Kinase ◽  
P38 Mapk ◽  
Mitogen Activated Protein Kinase ◽  
Neutrophil Apoptosis ◽  
Nuclear Factor ◽  
Phosphatidylinositol 3 Kinase ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
Mitogen Activated Protein ◽  
Nuclear Factor Kb

В обзоре представлены современные данные о механизмах инициации, регуляции и выполнении процесса апоптоза нейтрофилов с участием «рецепторов смерти», митохондрий, белков семейства Bcl-2, PI3-K (phosphatidylinositol 3-kinase), протеинкиназных каскадов p38 MAPK (mitogen-activated protein kinase), ERK (extracellular signal regulated kinase) и JNK (c-Jun N-terminal kinase), протеинкиназ А, В и С, сAMP, белков теплового шока, NF-kB (nuclear factor-kB), кальпаинов, каспаз и их ингибиторов, активных форм кислорода и других факторов. Предложена гипотетическая модель вовлечения апоптотических процессов в регуляцию дифференцировки и реактивности нейтрофилов. This review presented recent data on initiation, regulation, and execution of neutrophil apoptosis with participation of «death receptors», mitochondria, Bcl-2 family proteins, PI3-K (phosphatidylinositol 3-kinase), p38 MAPK (mitogen-activated protein kinase), ERK (extracellular signal regulated kinase) and JNK (c-Jun N-terminal kinase) cascades, protein kinases A, B and C, сAMP, heat shock proteins, NF-kB (nuclear factor-kB), calpains, caspases and theirs inhibitors, reactive oxygen species, and other factors. A speculative model of the apoptotic processes involvement in the regulation of neutrophil differentiation and reactivity was proposed.

Sign in / Sign up

Export Citation Format

Share Document