Induction of 1C aldoketoreductases and other drug dose-dependent genes upon acquisition of anthracycline resistance

Abstract One-hundred and fifty-one rabbits, divided into controls and animals treated with varying daily doses of warfarin, were subjected to the stasis assay, and the amount of thrombosis quantitated after intravascular coagulation was initiated either by activated factor X or tissue thromboplastin. Following 8–10 days of warfarin administration, there was a significant dose-dependent decrease in the vitamin-K- dependent coagulation factors paralleled by an increase in the prothrombin time ratio. Whether thrombosis was initiated by activated factor X or tissue thromboplastin, there was, with increasing drug dose, a progressive increase in the inhibition of stasis thrombosis. This significant antithrombotic effect occurred even when the vitamin-K- dependent coagulation activities were at a mean value of 50%.

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Organic semiconducting nanoprobe with redox-activatable NIR-II fluorescence forin vivoreal-time monitoring of drug toxicity

Chemical Communications ◽

10.1039/c8cc08413k ◽

2019 ◽

Vol 55 (1) ◽

pp. 27-30 ◽

Cited By ~ 16

Author(s):

Yufu Tang ◽

Yuanyuan Li ◽

Zhen Wang ◽

Feng Pei ◽

Xiaoming Hu ◽

...

Keyword(s):

Nitric Oxide ◽

Real Time ◽

Drug Toxicity ◽

Drug Dose ◽

Non Invasive ◽

Dose Dependent

A nitric-oxide-activatable organic semiconducting nanoprobe was developed forin vivo,in situ, real-time and non-invasive NIR-II fluorescence monitoring of drug-dose-dependent hepatotoxicity.

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Metabolomic studies in tissues of mice treated with amifostine and exposed to gamma-radiation

Scientific Reports ◽

10.1038/s41598-019-52120-w ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 2

Author(s):

Amrita K. Cheema ◽

Yaoxiang Li ◽

Michael Girgis ◽

Meth Jayatilake ◽

Madison Simas ◽

...

Keyword(s):

Bone Marrow ◽

Gamma Radiation ◽

Survival Benefit ◽

Ultra Performance Liquid Chromatography ◽

Drug Dose ◽

Dependent Manner ◽

Protective Effects ◽

Flight Mass Spectrometry ◽

Total Body ◽

Dose Dependent

Abstract Although multiple radioprotectors are currently being investigated preclinically for efficacy and safety, few studies have investigated concomitant metabolic changes. This study examines the effects of amifostine on the metabolic profiles in tissues of mice exposed to cobalt-60 total-body gamma-radiation. Global metabolomic and lipidomic changes were analyzed using ultra-performance liquid chromatography (UPLC) quadrupole time-of-flight mass spectrometry (QTOF-MS) in bone marrow, jejunum, and lung samples of amifostine-treated and saline-treated control mice. Results demonstrate that radiation exposure leads to tissue specific metabolic responses that were corrected in part by treatment with amifostine in a drug-dose dependent manner. Bone marrow exhibited robust responses to radiation and was also highly responsive to protective effects of amifostine, while jejunum and lung showed only modest changes. Treatment with amifostine at 200 mg/kg prior to irradiation seemed to impart maximum survival benefit, while the lower dose of 50 mg/kg offered only limited survival benefit. These findings show that the administration of amifostine causes metabolic shifts that would provide an overall benefit to radiation injury and underscore the utility of metabolomics and lipidomics to determine the underlying physiological mechanisms involved in the radioprotective efficacy of amifostine. This approach may be helpful in identifying biomarkers for radioprotective efficacy of amifostine and other countermeasures under development.

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Photodetection with 5-Aminolevulinic Acid–induced Protoporphyrin IX in the Rat Abdominal Cavity: Drug-dose–dependent Fluorescence Kinetics¶

Photochemistry and Photobiology ◽

10.1562/0031-8655(2000)072<0521:pwaaip>2.0.co;2 ◽

2000 ◽

Vol 72 (4) ◽

pp. 521 ◽

Cited By ~ 15

Author(s):

Maurice C. G. Aalders ◽

Henricus J. C. M. Sterenborg ◽

Fiona A. Stewart ◽

Nine van der Vange

Keyword(s):

Aminolevulinic Acid ◽

Abdominal Cavity ◽

Protoporphyrin Ix ◽

Drug Dose ◽

Fluorescence Kinetics ◽

Dose Dependent

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Dose-dependent antithrombotic effect of warfarin in rabbits

Blood ◽

10.1182/blood.v61.3.435.bloodjournal613435 ◽

1983 ◽

Vol 61 (3) ◽

pp. 435-438

Author(s):

SN Gitel ◽

S Wessler

Keyword(s):

Vitamin K ◽

Coagulation Factors ◽

Progressive Increase ◽

Drug Dose ◽

Mean Value ◽

Factor X ◽

Antithrombotic Effect ◽

Tissue Thromboplastin ◽

Dose Dependent Decrease ◽

Dose Dependent

One-hundred and fifty-one rabbits, divided into controls and animals treated with varying daily doses of warfarin, were subjected to the stasis assay, and the amount of thrombosis quantitated after intravascular coagulation was initiated either by activated factor X or tissue thromboplastin. Following 8–10 days of warfarin administration, there was a significant dose-dependent decrease in the vitamin-K- dependent coagulation factors paralleled by an increase in the prothrombin time ratio. Whether thrombosis was initiated by activated factor X or tissue thromboplastin, there was, with increasing drug dose, a progressive increase in the inhibition of stasis thrombosis. This significant antithrombotic effect occurred even when the vitamin-K- dependent coagulation activities were at a mean value of 50%.

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