scholarly journals A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT

2012 ◽  
Vol 22 (11) ◽  
pp. 796-802 ◽  
Author(s):  
Chad C. Brown ◽  
Tammy M. Havener ◽  
Marisa W. Medina ◽  
J. Todd Auman ◽  
Lara M. Mangravite ◽  
...  
Keyword(s):  
Cell Lines ◽  
Association Analysis ◽  
Genome Wide Association ◽  
Lymphoblastoid Cell Lines ◽  
Genome Wide Association Analysis ◽  
Genome Wide ◽  
A Genome

scholarly journals A genome-wide association analysis reveals a potential role for recombination in the evolution of antimicrobial resistance in Burkholderia multivorans

2018 ◽  
Vol 14 (12) ◽  
pp. e1007453 ◽  
Author(s):  
Julio Diaz Caballero ◽  
Shawn T. Clark ◽  
Pauline W. Wang ◽  
Sylva L. Donaldson ◽  
Bryan Coburn ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Association Analysis ◽  
Potential Role ◽  
Genome Wide Association ◽  
Burkholderia Multivorans ◽  
Genome Wide Association Analysis ◽  
Genome Wide ◽  
A Genome

scholarly journals A genome-wide association analysis for body, udder, and leg conformation traits recorded in Murciano-Granadina goats

2020 ◽  
Vol 103 (12) ◽  
pp. 11605-11617
Author(s):  
Maria Gracia Luigi-Sierra ◽  
Vincenzo Landi ◽  
Dailu Guan ◽  
Juan Vicente Delgado ◽  
Anna Castelló ◽  
...  
Keyword(s):  
Association Analysis ◽  
Genome Wide Association ◽  
Genome Wide Association Analysis ◽  
Genome Wide ◽  
A Genome

A genome-wide association analysis of chromosomal aberrations and Hirschsprung disease

2016 ◽  
Vol 177 ◽  
pp. 31-40.e6 ◽  
Author(s):  
Joon Seol Bae ◽  
InSong Koh ◽  
Hyun Sub Cheong ◽  
Jeong-Meen Seo ◽  
Dae-Yeon Kim ◽  
...  
Keyword(s):  
Association Analysis ◽  
Chromosomal Aberrations ◽  
Hirschsprung Disease ◽  
Genome Wide Association ◽  
Genome Wide Association Analysis ◽  
Genome Wide ◽  
A Genome

scholarly journals A genome-wide association analysis for susceptibility of pigs to enterotoxigenic Escherichia coli F41

animal ◽  
2016 ◽  
Vol 10 (10) ◽  
pp. 1602-1608 ◽  
Author(s):  
H.Y. Ji ◽  
B. Yang ◽  
Z.Y. Zhang ◽  
J. Ouyang ◽  
M. Yang ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Association Analysis ◽  
Enterotoxigenic Escherichia Coli ◽  
Genome Wide Association ◽  
Genome Wide Association Analysis ◽  
Genome Wide ◽  
A Genome

scholarly journals The ABO blood group locus and a chromosome 3 gene cluster associate with SARS-CoV-2 respiratory failure in an Italian-Spanish genome-wide association analysis

2020 ◽  
Author(s):  
David Ellinghaus ◽  
Frauke Degenhardt ◽  
Luis Bujanda ◽  
Maria Buti ◽  
Agustín Albillos ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Blood Group ◽  
Association Analysis ◽  
Meta Analysis ◽  
Genome Wide Association ◽  
Nucleotide Polymorphisms ◽  
Genome Wide Association Analysis ◽  
Genome Wide ◽  
A Genome ◽  
Group Locus

ABSTRACTBackgroundRespiratory failure is a key feature of severe Covid-19 and a critical driver of mortality, but for reasons poorly defined affects less than 10% of SARS-CoV-2 infected patients.MethodsWe included 1,980 patients with Covid-19 respiratory failure at seven centers in the Italian and Spanish epicenters of the SARS-CoV-2 pandemic in Europe (Milan, Monza, Madrid, San Sebastian and Barcelona) for a genome-wide association analysis. After quality control and exclusion of population outliers, 835 patients and 1,255 population-derived controls from Italy, and 775 patients and 950 controls from Spain were included in the final analysis. In total we analyzed 8,582,968 single-nucleotide polymorphisms (SNPs) and conducted a meta-analysis of both case-control panels.ResultsWe detected cross-replicating associations with rs11385942 at chromosome 3p21.31 and rs657152 at 9q34, which were genome-wide significant (P<5×10−8) in the meta-analysis of both study panels, odds ratio [OR], 1.77; 95% confidence interval [CI], 1.48 to 2.11; P=1.14×10−10 and OR 1.32 (95% CI, 1.20 to 1.47; P=4.95×10−8), respectively. Among six genes at 3p21.31, SLC6A20 encodes a known interaction partner with angiotensin converting enzyme 2 (ACE2). The association signal at 9q34 was located at the ABO blood group locus and a blood-group-specific analysis showed higher risk for A-positive individuals (OR=1.45, 95% CI, 1.20 to 1.75, P=1.48×10−4) and a protective effect for blood group O (OR=0.65, 95% CI, 0.53 to 0.79, P=1.06×10−5).ConclusionsWe herein report the first robust genetic susceptibility loci for the development of respiratory failure in Covid-19. Identified variants may help guide targeted exploration of severe Covid-19 pathophysiology.

A genome-wide association analysis identifies NMNAT2 and HCP5 as susceptibility loci for Kawasaki disease

2017 ◽  
Vol 62 (12) ◽  
pp. 1023-1029 ◽  
Author(s):  
Jae-Jung Kim ◽  
◽  
Sin Weon Yun ◽  
Jeong Jin Yu ◽  
Kyung Lim Yoon ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Association Analysis ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Genome Wide Association Analysis ◽  
Genome Wide ◽  
A Genome

P5009 A genome-wide association analysis for carcass and meat quality traits in Duroc pigs

2016 ◽  
Vol 94 (suppl_4) ◽  
pp. 119-120 ◽  
Author(s):  
R. Gonzalez ◽  
P. G. Eusebi ◽  
R. Quintanilla ◽  
T. Figueiredo ◽  
A. Manunza ◽  
...  
Keyword(s):  
Meat Quality ◽  
Association Analysis ◽  
Genome Wide Association ◽  
Quality Traits ◽  
Genome Wide Association Analysis ◽  
Meat Quality Traits ◽  
Genome Wide ◽  
A Genome
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