Physical activity and mortality in men and women with coronary heart disease: a prospective population-based cohort study in Norway (the HUNT study)

2008 ◽  
Vol 15 (6) ◽  
pp. 639-645 ◽  
Author(s):  
Trine Moholdt ◽  
Ulrik Wisløff ◽  
Tom Ivar L. Nilsen ◽  
Stig A. Slørdahl
Keyword(s):  
Physical Activity ◽  
Coronary Heart Disease ◽  
Cohort Study ◽  
Heart Disease ◽  
Population Based ◽  
Men And Women ◽  
Hunt Study

Abstract P008: Ultra-Sensitive Troponin I Strongly Predicts Incident Coronary Heart Disease in the General Population Independently of Traditional Risk Factors. Results From the MONICA/KORA Augsburg Case-Cohort Study

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Wolfgang Koenig ◽  
Astrid Zierer ◽  
Mahir Karakas ◽  
Christa Meisinger ◽  
Annette Peters ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Cohort Study ◽  
Heart Disease ◽  
Troponin I ◽  
Geometric Mean ◽  
Population Based ◽  
Men And Women ◽  
Traditional Risk Factors

Background: High-sensitive (hs) troponin T and I assays as well as ultrasensitive (us) troponin I enable measurement of troponins in 65% to 98% of the general population. We prospectively investigated whether increased concentrations of us-troponin I are associated with an increased risk of coronary heart disease (CHD) after controlling for traditional risk factors. Methods: We conducted a population-based case cohort study in middle-aged healthy men and women within the MONICA/KORA Augsburg studies. Serum levels of us-troponin I (Single Molecule Counting technology, Singulex) were available in 2,745 men and women including 803 incident CHD cases. Geometric mean us-troponin I was 1.56 ng/L. Mean (SD) follow-up was 16.0 (5.8) years. Results: Baseline concentrations of us-troponin I were higher in cases compared to non-cases (geometric mean 2.56 vs. 1.49 ng/L, p<0.0001) and in men compared to women (geometric mean 1.93 vs. 1.27 ng/L, p<0.0001). After adjustment for variables of the Framingham Risk Score, the hazard ratio (HR) with 95% confidence interval (CI) for a CHD event in the top quartile compared to the bottom quartile was 2.76 (95% CI, 1.87-4.09). After additional adjustment for alcohol intake, physical activity, and body mass index, hazard ratios remained essentially unchanged. Conclusions: Troponin I measured by an us-assay was detectable in almost all subjects. This is the first population-based prospective study with long-term follow-up showing that even modestly increased concentrations of us troponin I are strongly associated with incident CHD independently of a variety of traditional risk factors.

Depression, antidepressants, and the risk of coronary heart disease: A population-based cohort study

2013 ◽  
Vol 168 (5) ◽  
pp. 4711-4716 ◽  
Author(s):  
Chun-Jen Huang ◽  
Ming-Hsiung Hsieh ◽  
Wen-Hsuan Hou ◽  
Ju-Chi Liu ◽  
Chii Jeng ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Cohort Study ◽  
Heart Disease ◽  
Population Based
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