scholarly journals Severity of dental caries and risk of coronary heart disease in middle-aged men and women: a population-based cohort study of Korean adults, 2002–2013

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Kyuwoong Kim ◽  
Seulggie Choi ◽  
Jooyoung Chang ◽  
Sung Min Kim ◽  
Seon Jip Kim ◽  
...  
PLoS ONE ◽  
2018 ◽  
Vol 13 (10) ◽  
pp. e0206036 ◽  
Author(s):  
Ching-Hui Huang ◽  
Cheng-Liang Li ◽  
Chew-Teng Kor ◽  
Chia-Chu Chang

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Wolfgang Koenig ◽  
Astrid Zierer ◽  
Mahir Karakas ◽  
Christa Meisinger ◽  
Annette Peters ◽  
...  

Background: High-sensitive (hs) troponin T and I assays as well as ultrasensitive (us) troponin I enable measurement of troponins in 65% to 98% of the general population. We prospectively investigated whether increased concentrations of us-troponin I are associated with an increased risk of coronary heart disease (CHD) after controlling for traditional risk factors. Methods: We conducted a population-based case cohort study in middle-aged healthy men and women within the MONICA/KORA Augsburg studies. Serum levels of us-troponin I (Single Molecule Counting technology, Singulex) were available in 2,745 men and women including 803 incident CHD cases. Geometric mean us-troponin I was 1.56 ng/L. Mean (SD) follow-up was 16.0 (5.8) years. Results: Baseline concentrations of us-troponin I were higher in cases compared to non-cases (geometric mean 2.56 vs. 1.49 ng/L, p<0.0001) and in men compared to women (geometric mean 1.93 vs. 1.27 ng/L, p<0.0001). After adjustment for variables of the Framingham Risk Score, the hazard ratio (HR) with 95% confidence interval (CI) for a CHD event in the top quartile compared to the bottom quartile was 2.76 (95% CI, 1.87-4.09). After additional adjustment for alcohol intake, physical activity, and body mass index, hazard ratios remained essentially unchanged. Conclusions: Troponin I measured by an us-assay was detectable in almost all subjects. This is the first population-based prospective study with long-term follow-up showing that even modestly increased concentrations of us troponin I are strongly associated with incident CHD independently of a variety of traditional risk factors.


2013 ◽  
Vol 168 (5) ◽  
pp. 4711-4716 ◽  
Author(s):  
Chun-Jen Huang ◽  
Ming-Hsiung Hsieh ◽  
Wen-Hsuan Hou ◽  
Ju-Chi Liu ◽  
Chii Jeng ◽  
...  

2009 ◽  
Vol 218 (1) ◽  
pp. 19-26 ◽  
Author(s):  
ANTTI REUNANEN ◽  
OLLI SUHONEN ◽  
ARPO AROMAA ◽  
PAUL KNEKT ◽  
KALEVI PYÖRÄLÄ

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