Patterns of Recurrence in Endometrial Cancer Patients at Risk of Lymph Node Metastasis or Recurrence According to Extent of Lymphadenectomy

2012 ◽  
Vol 22 (4) ◽  
pp. 611-616 ◽  
Author(s):  
Ha-Jeong Kim ◽  
Tae-Joong Kim ◽  
Taejong Song ◽  
Min Kyu Kim ◽  
Yoo-Young Lee ◽  
...  
Keyword(s):  
At Risk ◽  
Endometrial Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Patients ◽  
Node Metastasis ◽  
Patients At Risk ◽  
Patterns Of Recurrence

Para-aortic lymphadenectomy can be omitted in most endometrial cancer patients at risk of lymph node metastasis

2017 ◽  
Vol 116 (2) ◽  
pp. 220-226 ◽  
Author(s):  
Glauco Baiocchi ◽  
Carlos Chaves Faloppa ◽  
Henrique Mantoan ◽  
Willian Ricardo Camarço ◽  
Levon Badiglian-Filho ◽  
...  
Keyword(s):  
At Risk ◽  
Endometrial Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Patients ◽  
Node Metastasis ◽  
Patients At Risk

One-step nucleic acid amplification vs ultrastaging in the detection of sentinel lymph node metastasis in endometrial cancer patients

2018 ◽  
Vol 119 (3) ◽  
pp. 361-369 ◽  
Author(s):  
Jan Kosťun ◽  
Martin Pešta ◽  
Jiří Sláma ◽  
Robert Slunéčko ◽  
Pavel Vlasák ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Nucleic Acid ◽  
Sentinel Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Patients ◽  
Nucleic Acid Amplification ◽  
Sentinel Lymph Node Metastasis ◽  
Node Metastasis ◽  
One Step

scholarly journals Predictors of Survival in Women with High-Risk Endometrial Cancer and Comparisons of Sandwich versus Concurrent Adjuvant Chemotherapy and Radiotherapy

2020 ◽  
Vol 17 (16) ◽  
pp. 5941
Author(s):  
Hui-Hua Chen ◽  
Wan-Hua Ting ◽  
Hsu-Dong Sun ◽  
Ming-Chow Wei ◽  
Ho-Hsiung Lin ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Endometrial Cancer ◽  
Lymph Node ◽  
High Risk ◽  
Lymph Node Metastasis ◽  
Cancer Patients ◽  
Body Mass ◽  
Paraaortic Lymph Node ◽  
Node Metastasis ◽  
Paraaortic Lymph Node Metastasis

Background: to elucidate the predictors of progression-free survival (PFS) and overall survival (OS) in high-risk endometrial cancer patients. Methods: the medical records of all consecutivewomen with high-risk endometrial cancer were reviewed. Results: among 92 high-risk endometrial cancer patients, 30 women experienced recurrence, and 21 women died. The 5-year PFS and OS probabilities were 65.3% and 75.9%, respectively. Multivariable Cox regression revealed that body mass index (hazard ratio (HR) = 1.11), paraaortic lymph node metastasis (HR = 11.11), lymphovascular space invasion (HR = 5.61), and sandwich chemoradiotherapy (HR = 0.15) were independently predictors of PFS. Body mass index (HR = 1.31), paraaortic lymph node metastasis (HR = 32.74), non-endometrioid cell type (HR = 11.31), and sandwich chemoradiotherapy (HR = 0.07) were independently predictors of OS. Among 51 women who underwent sandwich (n = 35) or concurrent (n = 16) chemoradiotherapy, the use of sandwich chemoradiotherapy were associated with better PFS (adjusted HR = 0.26, 95% CI = 0.08–0.87, p = 0.03) and OS (adjusted HR = 0.11, 95% CI = 0.02–0.71, p = 0.02) compared with concurrent chemoradiotherapy. Conclusion: compared with concurrent chemoradiotherapy, sandwich chemoradiotherapy was associated with better PFS and OS in high-risk endometrial cancer patients. In addition, high body mass index, paraaortic lymph node metastasis, and non-endometrioid cell type were also predictors of poor OS in high-risk endometrial cancer patients.

scholarly journals A novel model to estimate lymph node metastasis in endometrial cancer patients

Clinics ◽  
2017 ◽  
Vol 72 (1) ◽  
pp. 30-35 ◽  
Author(s):  
C Anton ◽  
AS Silva ◽  
EC Baracat ◽  
NU Dogan ◽  
C Köhler ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Patients ◽  
Node Metastasis ◽  
Novel Model

Nomogram with potential clinical use to predict lymph node metastasis in endometrial cancer patients diagnosed incidentally by postoperative pathological assessment

2017 ◽  
Vol 296 (4) ◽  
pp. 803-809 ◽  
Author(s):  
Salih Taşkın ◽  
Yavuz Emre Şükür ◽  
Bulut Varlı ◽  
Kazibe Koyuncu ◽  
Mehmet Murat Seval ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cancer Patients ◽  
Clinical Use ◽  
Node Metastasis ◽  
Pathological Assessment

Analysis of Metastatic Regional Lymph Node Locations and Predictors of Para-aortic Lymph Node Involvement in Endometrial Cancer Patients at Risk for Lymphatic Dissemination

2015 ◽  
Vol 25 (4) ◽  
pp. 657-664 ◽  
Author(s):  
Ayse Altay ◽  
Tayfun Toptas ◽  
Selen Dogan ◽  
Tayup Simsek ◽  
Elif Pestereli
Keyword(s):  
At Risk ◽  
Endometrial Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Predictive Value ◽  
Mesenteric Artery ◽  
Inferior Mesenteric Artery ◽  
Renal Vessels ◽  
Patients At Risk ◽  
The Impact

ObjectiveThe aim of this study was to provide detailed knowledge of the metastatic lymph node (LN) locations and to determine factors predicting para-aortic LN metastasis in endometrial cancer patients at risk (intermediate/high) for LN involvement.MethodsA prospective case series with planned data collection was conducted in a total of 173 patients who treated with systematic pelvic para-aortic lymphadenectomy up to the renal vessels. All the LNs removed from pelvic and para-aortic basins—low or high according to the level of the inferior mesenteric artery—were evaluated separately. Logistic regression analyses were performed to determine the impact of variables on para-aortic metastasis.ResultsLymph node metastasis was observed in 21.9% of the patients, pelvic LN involvement in 17.9%, para-aortic LN involvement in 15.0%, both pelvic and para-aortic LN involvement in 10.9%, and isolated para-aortic LN involvement in 4.0%. The most common metastatic LN locations were the external iliac (50.0%), obturator (50.0%), and low precaval regions (36.8%). The least common location of metastasis was the high precaval region (5.3%). Among patients with para-aortic LN metastasis, 42.3% had metastasis above the inferior mesenteric artery. The number of metastatic pelvic LNs greater than or equal to 2 was the only independent predictor of para-aortic metastasis in multivariate analysis (odds ratio, 23.38; 95% confidence interval, 1.35-403.99; P = 0.030), with 96.94% sensitivity, 95.87% specificity, 98.6% positive predictive value, and 97.0% negative predictive value.ConclusionsThe current study supports the idea that in patients at risk of LN involvement, the systematic lymphadenectomy should be performed up to the renal vessels due to the high rate of upper level involvement.

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